2013
DOI: 10.1038/onc.2013.183
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Role of Nek2 on centrosome duplication and aneuploidy in breast cancer cells

Abstract: Breast cancer is the most common solid tumor and the second most common cause of death in women. Despite a large body of literature and progress in breast cancer research, many molecular aspects of this complex disease are still poorly understood, hindering the design of specific and effective therapeutic strategies. To identify molecules important in breast cancer progression and metastasis, we tested the in vivo effects of inhibiting the functions of various kinases and genes involved in the regulation/modul… Show more

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Cited by 95 publications
(94 citation statements)
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“…Significantly, the breast cancer cell line which was most sensitive to NEK2 depletion was of the triple negative breast cancer subtype. These results indicate that NEK2 plays crucial roles in breast cancer growth at primary and secondary sites (31). Similarly, Wang et al (32) indicated that the abnormal expression of NEK2 and β-catenin may be one of the mechanisms for tumorigenesis, particularly for abnormal tumor proliferation, and the cytoplasmic expression of NEK2 is associated with both tumor grade and tumor size.…”
Section: Function Of Nek2 In Cancersmentioning
confidence: 84%
“…Significantly, the breast cancer cell line which was most sensitive to NEK2 depletion was of the triple negative breast cancer subtype. These results indicate that NEK2 plays crucial roles in breast cancer growth at primary and secondary sites (31). Similarly, Wang et al (32) indicated that the abnormal expression of NEK2 and β-catenin may be one of the mechanisms for tumorigenesis, particularly for abnormal tumor proliferation, and the cytoplasmic expression of NEK2 is associated with both tumor grade and tumor size.…”
Section: Function Of Nek2 In Cancersmentioning
confidence: 84%
“…Studies in Drosophila melanogaster and human diseases of Nek2 illustrated that overexpression of Nek2 correlated to activation of the Akt and JNK pathways, as well as upregulation of Wnt signaling, which are highly conserved in multiple species and involved in cellular growth and survival [40,41]. Therefore, Nek2 has been emerged as an important oncogene due to its regulatory role in mitosis and cancer related signaling pathways [41][42][43][44]. However, as another cancer related signaling which is also pivotal in development, the Hh signaling pathway had not previously been reported to correlate with Nek2.…”
Section: Discussionmentioning
confidence: 99%
“…NEK2 overexpression has been recognized in various cancers, including breast cancer, lymphoma, testicular seminomas, lung cancer, and colorectal cancer, and it has been shown to correlate with an aggressive phenotype and poor prognoses for these cancers (11,(31)(32)(33)(34). A recent study reported that NEK2 silencing by shRNAs reduces tumor cell progression by interference with chromosomal segregation in human breast cancer cell lines in vitro and in fat pad xenograft mouse models, leading to aneuploidy and subsequent cell death (35). Another study indicated that in human lung and colorectal cancer cell lines, NEK2 plays a critical role in the subcellular transfer of β-catenin from the plasma membrane to the cytoplasm and the nucleus, leading to an invasive cellular phenotype in vitro and in vivo (11,36).…”
Section: Methodsmentioning
confidence: 99%