Role of neopterin among COPD patients

Halim, Ashraf Abdel; Adawy, Zeinab; Sayed, Manal

doi:10.1016/j.ejcdt.2015.11.010

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…The combination of these factors causes significant increase in the work of breathing to maintain adequate ventilation and regulate blood gases in the normal range. As a consequence, the level of effective ventilation decreases in COPD over time which causes hypoxemia and hypercapnia [31, 35]. These effects in turn cause the bicarbonate concentration of the blood and the CSF to rise above normal to keep the blood pH level within an acceptable range [1].…”

Section: Resultsmentioning

confidence: 99%

Mathematical model of the human respiratory system in chronic obstructive pulmonary disease

Tehrani

2020

Healthc. technol. lett.

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Section: Resultsmentioning

confidence: 99%

Mathematical model of the human respiratory system in chronic obstructive pulmonary disease

Tehrani

2020

Healthc. technol. lett.

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Synthesis and characterization of graphene oxide-molecularly imprinted polymer for Neopterin adsorption study

et al. 2019

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Evaluation of inflammatory biomarkers and vitamins in hospitalized patients with SARS-CoV-2 infection and post-COVID syndrome

Krčmová,

Javorská,

Matoušová

et al. 2024

Clinical Chemistry and Laboratory Medicine (CCLM)

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Objectives Concentrations of neopterin, kynurenine and kynurenine/tryptophan ratios predict prognosis and the need for oxygen therapy in patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aims of the present study were to evaluate the changes of these biomarkers early in the course of infection, the association with the prior coronavirus disease (COVID-19) vaccination and therapeutic administration of Anti-SARS-CoV-2 monoclonal antibodies, investigation of other potential biomarkers including neuropilin, 8-hydroxy-2-deoxyguanosine and 8-hydroxyguanosine in patients hospitalized with SARS-CoV-2 infection and an assessment of these biomarkers and vitamins A, E and D in patients with post-COVID syndrome. Methods Urine and blood samples were obtained on the 1st to the 4th day and 4th to 7th day from 108 patients hospitalized with COVID-19. Chromatography tandem mass spectrometry methods were used to analyse neopterin, kynurenine, tryptophan, liposoluble vitamins, and DNA damage biomarkers. Results A statistically significant decrease of neopterin, kynurenine and kynurenine/tryptophan ratios was observed on after 4th to 7th day of hospitalization, and concentrations of these biomarkers were increased in patients with poor prognosis and subsequent post-COVID syndrome. The concentrations of remaining biomarker and vitamins were not associated with outcomes, although markedly decreased concentrations of vitamin A, E and D were noted. Conclusions The concentrations of neopterin, kynurenine and kynurenine/tryptophan ratios decrease during the course of infection SARS-CoV-2 and are associated with the post-COVID syndrome. No other prognostic biomarkers were identified.

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Role of neopterin among COPD patients

Cited by 3 publications

References 26 publications

Mathematical model of the human respiratory system in chronic obstructive pulmonary disease

Mathematical model of the human respiratory system in chronic obstructive pulmonary disease

Synthesis and characterization of graphene oxide-molecularly imprinted polymer for Neopterin adsorption study

Evaluation of inflammatory biomarkers and vitamins in hospitalized patients with SARS-CoV-2 infection and post-COVID syndrome

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