Role of Netrin-1 Signaling in Nerve Regeneration

Dun, Xin‐Peng; Parkinson, David B.

doi:10.3390/ijms18030491

Cited by 115 publications

(101 citation statements)

References 119 publications

(296 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(55) Interactions between DCC and netrin-1 are among the best-studied axonal guidance processes, with key roles during development and in adulthood, and they also affect angiogenesis. (56, 57) Increased expression of netrin-1 and DCC occurs in degenerate human intervertebral discs compared to healthy control discs, and in nucleus pulposus compared to annulus fibrosis. (58) Netrin-1/DCC might therefore mediate neurovascular ingrowth into the intervertebral disc, which has long been implicated as a possible mechanism of chronic discogenic back pain.…”

Section: Discussionmentioning

confidence: 99%

Genome-wide Meta-analysis of 158,000 Individuals of European Ancestry Identifies Three Loci Associated with Chronic Back Pain

Suri

Palmer

Tsepilov

et al. 2018

Preprint

View full text Add to dashboard Cite

OBJECTIVES To conduct a genome-wide association study (GWAS) meta-analysis of chronic back pain (CBP). METHODS Adults of European ancestry were included from 16 cohorts in Europe and North America. CBP cases were defined as those reporting back pain present for >3-6 months; non-cases were included as comparisons (“controls”). Each cohort conducted genotyping using commercially available arrays followed by imputation. GWAS used logistic regression models with additive genetic effects, adjusting for age, sex, study-specific covariates, and population substructure. The threshold for genome-wide significance in the fixed-effect inverse-variance weighted meta-analysis was p<5×10−8. Suggestive (p<5×10−7) and genome-wide significant (p<5×10−8) variants were carried forward for replication or further investigation in an independent sample. RESULTS The discovery sample was comprised of 158,025 individuals, including 29,531 CBP cases. A genome-wide significant association was found for the intronic variant rs12310519 in SOX5 (OR 1.08, p=7.2×10−10). This was subsequently replicated in an independent sample of 283,752 subjects, including 50,915 cases (OR 1.06, p=5.3×10−11), and exceeded genome-wide significance in joint meta-analysis (OR=1.07, p=4.5×10−19). We found suggestive associations at three other loci in the discovery sample, two of which exceeded genome-wide significance in joint meta-analysis: an intergenic variant, rs7833174, located between CCDC26 and GSDMC (OR 1.05, p=4.4×10−13), and an intronic variant, rs4384683, in DCC (OR 0.97, p=2.4×10−10). DISCUSSION In this first reported meta-analysis of GWAS for CBP, we identified and replicated a genetic locus associated with CBP (SOX5). We also identified 2 other loci that reached genome-wide significance in a 2-stage joint meta-analysis (CCDC26/GSDMC and DCC).

show abstract

Section: Discussionmentioning

confidence: 99%

Genome-wide Meta-analysis of 158,000 Individuals of European Ancestry Identifies Three Loci Associated with Chronic Back Pain

Suri

Palmer

Tsepilov

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…Still other treatments are in varying stages of development such as acupuncture (Huang and Qian, 2008), drugs (Chien et al, 2015;Bei, 2017), brimonidine (Lindsey et al, 2015), and another therapeutic options (Henrich-Noack, 2013; Kyung et al, 2015;Dun and Parkinson, 2017). The mechanism of the protective effect needs further in-depth study; however, all these findings are encouraging and open the possibility that further treatment and researches may become achievable in the future.…”

Section: About Treatmentmentioning

confidence: 99%

Updating traumatic optic neuropathy

Fuentes¹,

Pelier²

2018

Int. J. Med. Med. Sci.

View full text Add to dashboard Cite

Traumatic optic neuropathy (TON) is the affectation of the visual function, secondary to a damage caused by a direct or indirect traumatic mechanism over the optic nerve. It occurs in approximately 0.5 to 5% of closed head injuries, and in 2.5% of patients with maxillofacial trauma and mid-face fractures. The types of TON are direct, anterior indirect, posterior indirect, and chiasmal. This work aims to offer an updating in traumatic optic neuropathy. We made a search in international data bases such as PubMed, ClinicalTrial, Ebsco, Hinari and so on, and found 32 articles which were used in this review article. We used the following keywords: traumatic optic neuropathy, optic nerve, trauma, visual loss, visual disease. 70% of the articles correspond to the last five years. This review was redacted using Microsoft Office Word 2016 in a laptop Asus with Window 10 system. We made a compilation with diverse therapeutic options based principally in axonal regeneration developed by researchers during the last decade. The present review article provides an updating regarding potential strategies for axonal regeneration and optic nerve repair, focusing on the researches of many investigators around the world. Nowadays, therapeutic options have advanced in many fields, but still more researches must be done to find a definitive solution for traumatic optic neuropathy in a near future.

show abstract

“…Also, double-labelling of Netrin-1 and DCC showed that both markers were clearly co-localised in the cytoplasm of the neuronal cell bodies and processes. In the adult CNS, Netrin-1 expression is found in motor neurons and dorsal interneurons of the rodent spinal cord [23,24]. Particularly, Netrin-1 expression is mostly enriched in periaxonal myelin membranes, and Netrin-1 is thought to serve as a short-range cue to maintain the appropriately formed network structure in the adult mammalian CNS [25,26].…”

Section: Intrinsic Expression Of Netrin-1 and DCC In The Colonic Myenmentioning

confidence: 99%

Netrin-1-like-immunoreactivity Coexpresses With DCC and Has a Differential Level in the Myenteric Cholinergic and Nitrergic Neurons of the Adult Mouse Colon

Price

Blatch

et al. 2018

J Histochem Cytochem.

View full text Add to dashboard Cite

Netrin-1 is a potent axonal and neuronal guidance cue in the developing nervous system. Netrin-1 functions are mediated by its receptors, such as deleted in colorectal cancer (DCC) present on axons and neurons. Localisation of DCC and Netrin-1 on various types of enteric neurons and their role in the mature enteric nervous system is unknown. The results of our study revealed that almost all enteric neurons and processes express DCC and Netrin-1 in the adult mice. Netrin-1-like immunoreactivity (IR) was detected in the cytoplasm of neurons with some showing strong or weak staining. The majority of Netrin-1-like immunoreactive enteric neurons were choline acetyltransferase (ChAT)-positive. However, ~19% of neurons were strongly Netrin-1-like-positive but ChAT-negative while ~8% of neurons were Netrin-1-like-negative but strongly ChAT-positive. In contrast, almost all nitric oxide synthase (nNOS)positive enteric neurons displayed strong Netrin-1-like-IR. This differential intensity of Netrin-1 expression in the myenteric neurons might determine major neuronal subtypes regulating intestinal motility, ChAT-IR excitatory and nNOS-IR inhibitory muscle motor and interneurons. This is the first study demonstrating the localisation of DCC and Netrin-1 in the colonic myenteric plexus of the adult mice and their expression level determining two major neuronal subtypes regulating intestinal motility.

show abstract

Role of Netrin-1 Signaling in Nerve Regeneration

Cited by 115 publications

References 119 publications

Genome-wide Meta-analysis of 158,000 Individuals of European Ancestry Identifies Three Loci Associated with Chronic Back Pain

Genome-wide Meta-analysis of 158,000 Individuals of European Ancestry Identifies Three Loci Associated with Chronic Back Pain

Updating traumatic optic neuropathy

Netrin-1-like-immunoreactivity Coexpresses With DCC and Has a Differential Level in the Myenteric Cholinergic and Nitrergic Neurons of the Adult Mouse Colon

Contact Info

Product

Resources

About