Role of neuroimaging in initial assessment of subarachnoid hemorrhage

Alothman, Muhammad Hussam; Moscote-Salazar, Luis Rafael; Narvaez‐Rojas, Alexis Rafael; Quintana-Pájaro, Loraine; Dimitrov, A; Agrawal, Amit

doi:10.1016/j.neuchi.2019.06.003

Cited by 1 publication

(1 citation statement)

References 7 publications

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“…In addition, MRI, particularly fluid-attenuated inversion recovery (FLAIR) and T 2 *-weighted imaging ( T 2 *WI), can serve as the complementation of CT. FLAIR imaging can detect slight bleeding overlooked on conventional CT, while T 2 *WI are statistically significant indicators of subacute-to-chronic SAH. − These methods provide diagnostic information for patients with hemorrhage. However, there is still a lack of methods for precisely monitoring SAH in real time and the hemorrhage always progresses to a later stage when it is detected .…”

Section: Introductionmentioning

confidence: 99%

Hypersensitive MR Angiography for Diagnosis of Ischemic Stroke and Reperfusion Subarachnoid Hemorrhage

Zhang,

Cheng,

Liu

et al. 2024

Anal. Chem.

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Stroke is an acute injury of the central nervous system caused by the disorders of cerebral blood circulation, which has become one of the major causes of disability and death. Hemorrhage, particularly subarachnoid hemorrhage (SAH), is one of the poorest prognostic factors in stroke, which is related to the thrombolytic therapy, and has been considered very dangerous. In this context, the MR angiography with high sensitivity and resolution has been developed based on biocompatible paramagnetic ultrasmall NaGdF 4 nanoprobes. Owing to the appropriate hydrodynamic diameter, the nanoprobe can be confined inside the blood vessels and it only extravasates at the vascular injury site when the bleeding occurs. Relying on this property, the three-dimensional (3D) anatomic structures of artery occlusion of stroke rat can be precisely visualized; reperfusion-related SAH has been successfully visualized and identified. Benefiting from the long blood half-life of the nanoprobe, the observation window of MR angiography can last for the whole period of reperfusion, thereby monitoring the probable SAH in real time during thrombolytic therapy. More importantly, through reconstruction of multiparametric MRI, the arterial occlusion, cerebral ischemic region, and SAH can be simultaneously visualized in vivo in a 3D manner for the first time. Therefore, the current study provides a novel approach for both noninvasive 3D vascular visualization and hemorrhage alert, which possesses great prospects for clinical translation.

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