Role of Neuroimaging on Differentiation of Parkinson’s Disease and Its Related Diseases

Ogawa, Toshihide; Fujii, Shinya; Kuya, Keita; Kitao, Shinichiro; Shinohara, Yuki; Ishibashi, Mana; Tanabe, Yuji

doi:10.33160/yam.2018.09.001

Cited by 29 publications

(24 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These clinical findings partially correspond with the research on functional SPECT imaging in CBS and related disorders, in which asymmetrical blood flow to the cerebral cortex, especially frontoparietal lobes, and basal ganglia in CBD was observed, in opposition to PSP, in which decreased blood flow was more of bilateral distribution ( Zhang et al, 2001 ; Hossain et al, 2003 ; Ogawa et al, 2018 ). Okuda et al (2000) share similar data, as more extensive and asymmetric blood flow reductions were observed by them in CBD than in PSP patients, with distribution in inferior prefrontal, sensorimotor, and posterior parietal cortices, but not in the subcortical regions.…”

Section: Resultssupporting

confidence: 86%

The Significance of Vascular Pathogenesis in the Examination of Corticobasal Syndrome

Dunalska

Pikul

Schok

et al. 2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

Corticobasal syndrome (CBS) is a clinical entity, classified as an atypical Parkinsonism, characterized by both motor and higher cortical dysfunctions. The clinical manifestation of CBS is associated with several pathologies, among which corticobasal degeneration (CBD) is the most common. The aim of our study was to elaborate on the possible vascular pathogenesis of CBS and consider types of vascular lesions in these cases. Several cases of vascular CBS are described in the literature. The majority of presented patients were affected by internal carotid artery (ICA) stenosis and ischemic strokes; few cases were associated with vascular malformations or autoimmune diseases. Vascular CBS is preceded by an abrupt onset. The clinical manifestation does not significantly differ with non-vascular CBS. Patients with vascular CBS are usually elderly; often with coexistent hypertension, dyslipidemia and diabetes mellitus. Inferring from our observations, cerebral hypoperfusion can play a significant role in neuropathological changes in neurodegenerative diseases. To the best of our knowledge paper is the first comprehensive review of vascular CBS and we are positive that our observations show that further research concerning the vascular pathogenesis of tauopathy atypical Parkinsonism is required.

show abstract

Section: Resultssupporting

confidence: 86%

The Significance of Vascular Pathogenesis in the Examination of Corticobasal Syndrome

Dunalska

Pikul

Schok

et al. 2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…At this time, imaging findings are not included as part of the proposed diagnostic criteria for CBD [1]. However, T2-weighted and FLAIR images may reveal asymmetric atrophy of the posterior frontal and parietal lobes [3]. Asymmetric hypometabolism can also be seen on 18 Ffluorodeoxyglucose PET imaging [3].…”

Section: Discussionmentioning

confidence: 99%

“…However, T2-weighted and FLAIR images may reveal asymmetric atrophy of the posterior frontal and parietal lobes [3]. Asymmetric hypometabolism can also be seen on 18 Ffluorodeoxyglucose PET imaging [3]. Corticobasal degeneration is poorly-responsive to levodopa and there are no disease-modifying treatments or approved pharmacological or therapeutic at this time [4].…”

Section: Discussionmentioning

confidence: 99%

A case of profound asymmetry in motor skills

Zuzuárregui¹,

Hohler²,

Menezes³

2019

Journal of Clinical Neuroscience

View full text Add to dashboard Cite

A 71 year-old female with thyroid disease presented for rapidly progressive cognitive dysfunction. Three years prior, the patient began to experience difficulty with performing motor tasks and neglecting the right side of her body. Attention and concentration also declined. Gait slowed with shortening of stride length. Memory and ability to name objects remained intact. She had no hallucinations, gaze limitation, dream enactment behavior or myoclonus. She had been placed on donepezil and paroxetine with no improvement. Neurologic examination revealed frontal release signs, ideomotor apraxia and hypomimia. Intermittent dystonia, rigidity and astereognosis of the right hand were seen. Gait examination revealed retropulsion and a slowed gait. Initial testing was within normal limits, including a basic metabolic panel, complete blood count, vitamin B12, thyroid stimulating hormone, Venereal Disease Research Laboratory test, C-reactive protein and erythrocyte sedimentation rate. Cerebrospinal fluid (CSF) testing revealed one red blood cell/uL, one white blood cell/uL, protein of 29 mg/dL, glucose of 54. CSF culture, gram stain and 14-3-3 protein were both negative. Further CSF analysis revealed A-beta 42 (734.75 pg/ml), phospho-tau (70.55 pg/ml) and total-tau levels (453.95 pg/ml) with A-beta 42/total-tau index (ATI; 0.95), borderline for Alzhemier's disease (Values for Alzheimer's: phospho-tau >68 pg/ml; ATI >1.2). Magnetic resonance imaging (MRI) of the brain showed atrophy of the left parietal lobe (Fig. 1). Positive emission tomography (PET) demonstrated reduced uptake in the left parietal lobe (Fig. 2).

show abstract

“…However, parkinsonism and reduced DAT uptake may also be seen in disorders such as PSP, MSA, CBD, and frontotemporal dementia; therefore, caution must be exercised in diagnosing dementia patients with probable DLB when parkinsonism is the only core clinical feature present. Occasionally, normal DAT uptake may also be seen in autopsyconfirmed DLB due to limited nigral neuron loss or a balanced loss of dopamine across the whole striatum [77].…”

Section: Indicative Biomarkersmentioning

confidence: 99%

Diagnosis of Dementia with Lewy Bodies: Fluctuations, Biomarkers, and Beyond

Olichney¹,

Li²,

Gharbaoui³

et al. 2022

Dementia in Parkinson’s Disease - Everything You Need to Know

View full text Add to dashboard Cite

Dementia with Lewy bodies (DLB), the second most common cause of dementia, remains a difficult condition to accurately diagnose and manage. Variable involvement of motor and cognitive functions, plus psychiatric and behavioral symptoms, contributes to the difficulty in managing DLB. Additionally, DLB can cause severe sleep disruption through REM sleep behavior disorder, autonomic symptoms, disruptions of olfaction/taste and mood, hallucinations, and more. In this chapter, advances and remaining challenges in the diagnosis of DLB are discussed, including a review of the current consensus criteria for DLB. The spectrum of disorders with Lewy bodies (LBs) are described including their wide-range of clinical presentations and overlap with Alzheimer’s disease (AD) and Parkinson’s disease with and without dementia. Particular consideration is given to advancements in quantification of cognitive fluctuations through improved clinical instruments, EEG, and other advanced biomarkers. Detection of DLB has improved, but establishing the “primary” pathology in cases with concomitant LB andd AD remains difficult. Likelihood of a clinical DLB syndrome is thought to be a function of distribution of LBs and severity of AD-type pathology. Further work is needed to better understand LB disease subtypes and the underlying pathophysiological mechanisms to allow for more targeted and comprehensive therapies.

show abstract

Role of Neuroimaging on Differentiation of Parkinson’s Disease and Its Related Diseases

Cited by 29 publications

References 54 publications

The Significance of Vascular Pathogenesis in the Examination of Corticobasal Syndrome

The Significance of Vascular Pathogenesis in the Examination of Corticobasal Syndrome

A case of profound asymmetry in motor skills

Diagnosis of Dementia with Lewy Bodies: Fluctuations, Biomarkers, and Beyond

Contact Info

Product

Resources

About