Role of neuronal nicotinic acetylcholine receptors in cannabinoid dependence

Buzzi, B; Moncayo, L; Shoaib, Mohammed; Damaj, M. Imad

doi:10.1016/j.phrs.2023.106746

Cited by 4 publications

(3 citation statements)

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“…Cannabis and nAChR receptors co-distribute in the same brain areas, suggesting that the two systems can engage in cross-talk [ 86 ]. Tobacco and cannabis are the most common drugs of abuse consumed by adolescents and young adults [ 87 , 88 ]. The co-use of these drugs has been suggested to produce mutually reinforcing effects and a decrease in adverse effects [ 89 ].…”

Section: Addictionmentioning

confidence: 99%

“…A recent study found that individuals with cannabinoid use disorder present reduced expression of the CHRNA2 gene in the cerebellum, suggesting that the gene that encodes for the α2 nAChR subunit may be involved in the susceptibility to developing this disorder. Furthermore, a negative correlation between the gene expressions of CHRNA2 and CNR1 (cannabinoid receptor 1) in the cerebellar cortex and cerebellar nuclei has been reported [ 87 ]. Participation of the homomeric α7 nAChR has been linked to the rewarding effects of cannabinoid use, while the α4β2 nAChR subtype has been associated with a reduction in cannabinoid-induced ataxia, and as such with a reduction in cannabinoid-induced motor impairment.…”

Section: Addictionmentioning

confidence: 99%

“…Participation of the homomeric α7 nAChR has been linked to the rewarding effects of cannabinoid use, while the α4β2 nAChR subtype has been associated with a reduction in cannabinoid-induced ataxia, and as such with a reduction in cannabinoid-induced motor impairment. In addition, the potential roles of the α5, α3, and β4 nAChR subunits in cannabinoid use disorder, particularly in tolerance- and withdrawal-associated symptoms, have been addressed [ 87 ].…”

Section: Addictionmentioning

confidence: 99%

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Nicotinic Acetylcholine Receptor Dysfunction in Addiction and in Some Neurodegenerative and Neuropsychiatric Diseases

Vallés

Barrantes

2023

Cells

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The cholinergic system plays an essential role in brain development, physiology, and pathophysiology. Herein, we review how specific alterations in this system, through genetic mutations or abnormal receptor function, can lead to aberrant neural circuitry that triggers disease. The review focuses on the nicotinic acetylcholine receptor (nAChR) and its role in addiction and in neurodegenerative and neuropsychiatric diseases and epilepsy. Cholinergic dysfunction is associated with inflammatory processes mainly through the involvement of α7 nAChRs expressed in brain and in peripheral immune cells. Evidence suggests that these neuroinflammatory processes trigger and aggravate pathological states. We discuss the preclinical evidence demonstrating the therapeutic potential of nAChR ligands in Alzheimer disease, Parkinson disease, schizophrenia spectrum disorders, and in autosomal dominant sleep-related hypermotor epilepsy. PubMed and Google Scholar bibliographic databases were searched with the keywords indicated below.

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