Role of Neuropeptide Y in Myocardial Contractility of Rats during Early Postnatal Ontogeny

Zverev, A. A.; Anikina, T. A.; Maslyukov, P. M.; rov, T. L. Zefi

doi:10.1007/s10517-014-2581-2

Cited by 7 publications

(3 citation statements)

References 6 publications

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“…On the other hand, in the Langendorff procedure, we used 12-week-old mice and revealed that NPY showed neither positive nor negative inotropic and chronotropic effects. This result is in agreement with the findings of Zverev et al (2014) . In general SC occurred in adults and is uncommon in juveniles.…”

Section: Discussionsupporting

confidence: 94%

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Upregulation of neuropeptide Y in cardiac sympathetic nerves induces stress (Takotsubo) cardiomyopathy

Arai

Kimura²,

Munakata

et al. 2022

Front. Neurosci.

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Substantial emotional or physical stress may lead to an imbalance in the brain, resulting in stress cardiomyopathy (SC) and transient left ventricular (LV) apical ballooning. Even though these conditions are severe, their precise underlying mechanisms remain unclear. Appropriate animal models are needed to elucidate the precise mechanisms. In this study, we established a new animal model of epilepsy-induced SC. The SC model showed an increased expression of the acute phase reaction protein, c-Fos, in the paraventricular hypothalamic nucleus (PVN), which is the sympathetic nerve center of the brain. Furthermore, we observed a significant upregulation of neuropeptide Y (NPY) expression in the left stellate ganglion (SG) and cardiac sympathetic nerves. NPY showed neither positive nor negative inotropic and chronotropic effects. On the contrary, NPY could interrupt β-adrenergic signaling in cardiomyocytes when exposure to NPY precedes exposure to noradrenaline. Moreover, its elimination in the left SG via siRNA treatment tended to reduce the incidence of SC. Thus, our results indicated that upstream sympathetic activation induced significant upregulation of NPY in the left SG and cardiac sympathetic nerves, resulting in cardiac dysfunctions like SC.

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Section: Discussionsupporting

confidence: 94%

“…NPY had little effect on the myocardium of 100-day-old rats. The reaction of the myocardium to NPY appears to differ with age ( Zverev et al, 2014 ). The study examined the reaction of the myocardium after stimulation.…”

Section: Discussionmentioning

confidence: 99%

Upregulation of neuropeptide Y in cardiac sympathetic nerves induces stress (Takotsubo) cardiomyopathy

Arai

Kimura²,

Munakata

et al. 2022

Front. Neurosci.

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“…Previous studies suggested that NPY can suppress myocardial contractility by inhibiting the energy metabolism of mitochondria in the cardiomyocytes. [ 20 21 ] Therefore, it is reasonable to propose that the upright plasma NPY may take part in the decline of CO in the positive-response period during the HUT by suppressing myocardial contractility. As mentioned above, the increase in the TPVR and the decline in CO are characteristic responses in children with VVS during the HUT.…”

Section: Discussionmentioning

confidence: 99%

Plasma Neuropeptide Y Levels in Vasovagal Syncope in Children

Liao

et al. 2017

Chinese Medical Journal

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Background:Vasovagal syncope (VVS) is the most common cause of syncope in children. Neuropeptide Y (NPY) plays an important role in the regulation of blood pressure (BP), as well as myocardial contractility. This study aimed to explore the role of plasma NPY in VVS in children.Methods:Fifty-six children who were diagnosed with VVS (VVS group) using head-up tilt test (HUT) and 31 healthy children who were selected as controls (control group) were enrolled. Plasma NPY concentrations were detected. The independent t-test was used to compare the data of the VVS group with those of the control group. The changes in plasma NPY levels in the VVS group during the HUT, as well as hemodynamic parameters, such as heart rate (HR), BP, total peripheral vascular resistance (TPVR), and cardiac output (CO), were evaluated using the paired t-test. Furthermore, the correlations between plasma NPY levels and hemodynamic parameters were analyzed using bivariate correlation analysis.Results:The BP, HR, and plasma NPY (0.34 ± 0.12 pg/ml vs. 0.46 ± 0.13 pg/ml) levels in the supine position were statistically low in the VVS group compared to levels in the control group (all P < 0.05). Plasma NPY levels were positively correlated with the HR (Pearson, R = 0.395, P < 0.001) and diastolic BP (Pearson, R = 0.311, P = 0.003) when patients were in the supine position. When patients in the VVS group were in the supine position, elevated TPVR (4.6 ± 3.7 mmHg·min−1·L−1 vs. 2.5 ± 1.0 mmHg·min−1·L−1, respectively, P < 0.001; 1 mmHg = 0.133 kPa) and reduced CO (1.0 ± 0.7 L/min vs. 2.4 ± 1.3 L/min, respectively, P < 0.001) were observed in the positive-response period compared with baseline values. The plasma NPY levels were positively correlated with TPVR (Spearman, R = 0.294, P = 0.028) but negatively correlated with CO in the positive-response period during HUT (Spearman, R = −0.318, P = 0.017).Conclusions:Plasma NPY may contribute to the pathogenesis of VVS by increasing the TPVR and decreasing the CO during orthostatic regulation.

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NPY1 Receptors Participate in the Regulation of Myocardial Contractility in Rats

et al. 2017

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Selective agonist (Leu(31)Pro(34)NPY) and blocker (BIBP-3226) of NPY1 receptors were used to determine the type of NPY receptors involved in myocardial contraction. Experiments with isometric contraction of myocardial strips from mature rats showed that the agonist produced the most potent effect in a concentration of 10 M. In this concentration, Leu(31)Pro(34)NPY showed the greatest positive inotropic effect on the contraction of the atria and ventricles. In contrast, selective blocker BIBP-3226 reduced the force of myocardial contractions. Pretreatment of myocardial strips with this blocker abolished the positive inotropic effect of Leu(31)Pro(34)NPY, which attested to important role of NPY receptors in myocardial contraction.

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Role of Neuropeptide Y in Myocardial Contractility of Rats during Early Postnatal Ontogeny

Cited by 7 publications

References 6 publications

Upregulation of neuropeptide Y in cardiac sympathetic nerves induces stress (Takotsubo) cardiomyopathy

Upregulation of neuropeptide Y in cardiac sympathetic nerves induces stress (Takotsubo) cardiomyopathy

Plasma Neuropeptide Y Levels in Vasovagal Syncope in Children

NPY1 Receptors Participate in the Regulation of Myocardial Contractility in Rats

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