Role of neuropeptide Y Y2 receptors in modulation of cardiac parasympathetic neurotransmission

Smith-White, Margaret A; Herzog, Herbert; Potter, Erica K.

doi:10.1016/s0167-0115(01)00368-8

Cited by 62 publications

(30 citation statements)

References 25 publications

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“…It was reported that Y1R deleted mice showed normal baseline SBP and HR, even though the vasoconstrictor action of both NPY and noradrenaline-induced BP modulation were blocked in these mice. Despite the increased baseline HR of Y2R deficient mice, the baseline SBP was also reported unaffected [31,32]. It is worth noting that some of these animal models were involved central Y1R/ Y2R, and revealed an integrated role of Y1R/Y2R in balancing baseline SBP and HR.…”

Section: Discussionmentioning

confidence: 99%

Blockage of Peripheral NPY Y1 and Y2 Receptors Modulates Barorefex Sensitivity of Diabetic Rats

Liu

Wang²,

Xie³

et al. 2013

Cell Physiol Biochem

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Background/Aims: Abnormal baroreceptor reflex sensitivity (BRS) and elevated plasma neuropeptide Y (NPY) are prevalent in diabetic patients. The present study was conducted to determine whether NPY Y1 receptor (Y1R) and NPY Y2 receptor (Y2R) contribute to the regulatin of BRS in diabetic rats. Methods: Diabetes mellitus (DM) rats with hyperlipidemia were developed by an emulsion diet enriched with fat, sucrose and fructose followed by streptozocin (STZ). Y1R and Y2R specific antagonists (BIBP 3226 and BIIE 0246) were administered by a mini-osmotic pump. Systolic blood pressure (SBP), heart rate (HR), BRS and heart functions, as well as the plasma NPY and lipid level were measured after treatment for 4 weeks. Results: Both BIBP 3226 and BIIE 0246 treatment reversed the elevated total cholesterol (TC) and low density lipoprotein (LDL-C) level, and reduced high density lipoprotein (HDL-C) level in DM rats. BIIE 0246 may attenuate the increased triglyceride (TG) level in DM rats. In addition, neither BIBP 3226 nor BIIE 0246 treatment produced significant effects on BRS, SBP or HR (P>0.05) in DM rats, even after PE and SNP challenge. However, BIBP 3226 and BIIE 0246 further impaired LVSP, LVEDP, +dp/dt_max and -dp/dt_max. Conclusion: This study provided us with the evidence that the inhibition of peripheral Y1R and Y2R did not affect impaired BRS but amplified the deterioration of the compromised cardiac function in STZ-induced DM rats with hyperlipidemia.

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Section: Discussionmentioning

confidence: 99%

Blockage of Peripheral NPY Y1 and Y2 Receptors Modulates Barorefex Sensitivity of Diabetic Rats

Liu

Wang²,

Xie³

et al. 2013

Cell Physiol Biochem

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“…Therefore, NPY was proposed to regulate inhibition of cholinergic vagal action evoked by the sympathetic nervous system in the heart [165]. Indeed, N-acetyl [Leu 28,31 ] NPY 24-36 , a selective Y2 agonist, mimicked the inhibitory effect of NPY on cardiac vagal activity [166,167] and on cholinergic mediated vasodilatation [60,168]. Moreover, the Y2 antagonist BIIE0246 attenuated the inhibitory effect of N-acetyl [Leu 28,31 ] NPY 24-36 on vagal-induced bradycardia, suggesting also the presence of functional Y2 receptors in parasympathetic junctions in the heart.…”

Section: Prejunctional Npy Actionsmentioning

confidence: 99%

Neuropeptide Y: the universal soldier

Pedrazzini¹,

Pralong

Grouzmann³

2003

Cellular and Molecular Life Sciences (CMLS)

253

158

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The peptidic neuropeptide Y (NPY) has received great attention because it has been implicated in the regulation of several organ systems. In particular, NPY is involved in the regulatory loops that control food intake in the hypothalamus and appears also to be important for regulating the activity of neuroendocrine axes under poor metabolic conditions. Furthermore, NPY exerts vasoconstrictive action on the vasculature and potentiates the actions of many other vasoconstrictors. In addition, it was demonstrated to have trophic properties and could therefore contribute to cardiovascular remodeling. These various effects plus a number of others make NPY an attractive target for the potential treatment of human diseases, such as obesity, metabolic disorders, hypertension and heart failure.

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“…In particular, the level of plasma NPY has been proposed as a biomarker to assess the severity and prognosis of patients suffering from cardiovascular diseases [15]. Among the six identified NPY receptor subtypes, Y1R, Y2R and Y5R are distributed widely in the cardiovascular system [8], with Y1R mediating a vasoconstrictor response, Y2R mediating the decrease of HR and Y5R facilitating cardiac hypertrophy [16][17][18]. And microinjection of Y1R agonist into NTS led to vasodepressor and bradycardic responses [19].…”

Section: Introductionmentioning

confidence: 99%

Long-term Neuropeptide Y Administration in the Periphery Induces Abnormal Baroreflex Sensitivity and Obesity in Rats

Xie

Zhang

et al. 2012

Cell Physiol Biochem

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Neuropeptide Y (NPY) is an important neuronal element involved in cardiovascular regulation. Since elevated plasma levels of NPY have been observed in numerous pathological situations, this study aimed to determine whether long-term elevated plasma concentrations of NPY could result in aberrant baroreflex sensitivity. Mini-osmotic pump containing NPY (85 µg per 30 days) was subcutaneously implanted between scapulae in male rats for 4 months. The rats treated with NPY showed the following characters compared with control group: (1) attenuated heart rate responding to the increases in mean arterial blood pressure (MABP) induced by phenylephrine, but enhanced heart rate responding to the decreases in MABP induced by sodium nitroprusside; (2) decreased protein levels of substance P (SP) and GluR2, while increased the expression of γ-aminobutyric acid A receptor (GABA_AR) in brainstem; (3) abdominal obesity indicated by increased body weight and accumulated fat mass in peritoneal cavity; (4) significant increases in total cholesterol, triglycerides, and low density lipoprotein levels in the periphery. These findings indicate that long-term NPY administration in the periphery leads to abnormal baroreflex sensitivity due, at least in part, to the down-regulated expression of SP/GluR2 and elevated expression of GABA_AR in both protein and RNA levels, which indicate the alternations in glutamate function and GABA action in the nucleus tractus solitarii in NPY-treated rats. Furthermore, long-term NPY administration results in abdominal obesity and dyslipidemia.

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Role of neuropeptide Y Y2 receptors in modulation of cardiac parasympathetic neurotransmission

Cited by 62 publications

References 25 publications

Blockage of Peripheral NPY Y1 and Y2 Receptors Modulates Barorefex Sensitivity of Diabetic Rats

Blockage of Peripheral NPY Y1 and Y2 Receptors Modulates Barorefex Sensitivity of Diabetic Rats

Neuropeptide Y: the universal soldier

Long-term Neuropeptide Y Administration in the Periphery Induces Abnormal Baroreflex Sensitivity and Obesity in Rats

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