Role of neutrophils, platelets, and extracellular vesicles and their interactions in COVID‐19‐associated thrombopathy

Caillon, Antoine; Trimaille, Antonin; Favre, Julie; Jesel, Laurence; Morel, Olivier; Kauffenstein, Gilles

doi:10.1111/jth.15566

Cited by 53 publications

(52 citation statements)

References 204 publications

(379 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Interactions between platelets and neutrophils are crucial for inflammation and immunity [ 61 ]. Currently, the platelet–neutrophil crosstalk is well characterized ( Figure 1 ), both in physiologic and pathologic conditions, where the thromboinflammatory response is often described as “a vicious cycle” [ 62 ]. Upon vessel wall damage, platelets are activated, adhere, change their shape, secrete their granule contents and start to form aggregates [ 63 ].…”

Section: Platelets and Neutrophils Interactions In Homeostasis And Pa...mentioning

confidence: 99%

Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation

Mandel

Casari

Stepanyan

et al. 2022

IJMS

View full text Add to dashboard Cite

There is accumulating evidence that platelets play roles beyond their traditional functions in thrombosis and hemostasis, e.g., in inflammatory processes, infection and cancer, and that they interact, stimulate and regulate cells of the innate immune system such as neutrophils, monocytes and macrophages. In this review, we will focus on platelet activation in hemostatic and inflammatory processes, as well as platelet interactions with neutrophils and monocytes/macrophages. We take a closer look at the contributions of major platelet receptors GPIb, αIIbβ3, TLT-1, CLEC-2 and Toll-like receptors (TLRs) as well as secretions from platelet granules on platelet–neutrophil aggregate and neutrophil extracellular trap (NET) formation in atherosclerosis, transfusion-related acute lung injury (TRALI) and COVID-19. Further, we will address platelet–monocyte and macrophage interactions during cancer metastasis, infection, sepsis and platelet clearance.

show abstract

Section: Platelets and Neutrophils Interactions In Homeostasis And Pa...mentioning

confidence: 99%

Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation

Mandel

Casari

Stepanyan

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…Accumulated clues to the puzzle of SARS-CoV-2 have suggested that when a virus can initiate platelet and neutrophil driven exacerbated macrophage inflammatory circuits, this can spell a pandemic. The molecules of the purinergic signalling pathway receptosome are directly implicated as key mediators for the interactions between cells involved in these principle pathological processes of concern (223)(224)(225)(226). Despite available vaccines and emergency use antibodies (EUA), a pharmacological prevention and treatment therapy of COVID-19 is still urgently needed, especially for PACS sequelae.…”

Section: Discussionmentioning

confidence: 99%

The Potential of Purinergic Signaling to Thwart Viruses Including SARS-CoV-2

2022

View full text Add to dashboard Cite

A long-shared evolutionary history is congruent with the multiple roles played by purinergic signaling in viral infection, replication and host responses that can assist or hinder viral functions. An overview of the involvement of purinergic signaling among a range of viruses is compared and contrasted with what is currently understood for SARS-CoV-2. In particular, we focus on the inflammatory and antiviral responses of infected cells mediated by purinergic receptor activation. Although there is considerable variation in a patient’s response to SARS-CoV-2 infection, a principle immediate concern in Coronavirus disease (COVID-19) is the possibility of an aberrant inflammatory activation causing diffuse lung oedema and respiratory failure. We discuss the most promising potential interventions modulating purinergic signaling that may attenuate the more serious repercussions of SARS-CoV-2 infection and aspects of their implementation.

show abstract

“…TF-harboring cells shed high amounts of EVs from their surfaces. EVs, in turn, are associated with increased plasmatic thrombin generation and thromboembolic events, with endothelial cytokine release and leukocyte activation in COVID-19 patients [ 153 ].…”

Section: The Role Of Platelets In Pulmonary Inflammationmentioning

confidence: 99%

Platelets at the Crossroads of Pro-Inflammatory and Resolution Pathways during Inflammation

Ludwig

Hilger

Zarbock

et al. 2022

Cells

View full text Add to dashboard Cite

Platelets are among the most abundant cells in the mammalian circulation. Classical platelet functions in hemostasis and wound healing have been intensively explored and are generally accepted. During the past decades, the research focus broadened towards their participation in immune-modulatory events, including pro-inflammatory and, more recently, inflammatory resolution processes. Platelets are equipped with a variety of abilities enabling active participation in immunological processes. Toll-like receptors mediate the recognition of pathogens, while the release of granule contents and microvesicles promotes direct pathogen defense and an interaction with leukocytes. Platelets communicate and physically interact with neutrophils, monocytes and a subset of lymphocytes via soluble mediators and surface adhesion receptors. This interaction promotes leukocyte recruitment, migration and extravasation, as well as the initiation of effector functions, such as the release of extracellular traps by neutrophils. Platelet-derived prostaglandin E2, C-type lectin-like receptor 2 and transforming growth factor β modulate inflammatory resolution processes by promoting the synthesis of pro-resolving mediators while reducing pro-inflammatory ones. Furthermore, platelets promote the differentiation of CD4+ T cells in T helper and regulatory T cells, which affects macrophage polarization. These abilities make platelets key players in inflammatory diseases such as pneumonia and the acute respiratory distress syndrome, including the pandemic coronavirus disease 2019. This review focuses on recent findings in platelet-mediated immunity during acute inflammation.

show abstract

Role of neutrophils, platelets, and extracellular vesicles and their interactions in COVID‐19‐associated thrombopathy

Cited by 53 publications

References 204 publications

Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation

Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation

The Potential of Purinergic Signaling to Thwart Viruses Including SARS-CoV-2

Platelets at the Crossroads of Pro-Inflammatory and Resolution Pathways during Inflammation

Contact Info

Product

Resources

About