Role of nicotine in gallbladder carcinoma: A preliminary report

Basu, Somprakas; Priya, Rupesh; Singh, Tej Bali; Srivastava, Pradeep; Mishra, Pradeep Kumar; Shukla, Vijay K.

doi:10.1111/j.1751-2980.2012.00623.x

Cited by 7 publications

(2 citation statements)

References 25 publications

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“…18,42 Cancers that can be caused by nicotine include small-cell and non-small-cell lung carcinomas, head and neck, gastric, pancreatic, gallbladder, liver, colon, breast, cervical, urinary bladder, and kidney cancers. 39,[43][44][45][46][47] In other words, nicotine is an addictive but non-carcinogenic substance that performs its biological function through nAChR, b-adrenoreceptors, and/or epidermal growth factor receptor (EGFR) in the motor muscle endplates and the nervous system. [48][49][50] Consumption of nicotine derivatives in mice causes pulmonary adenocarcinoma (PAC), so it can also cause PAC in smokers.…”

Section: Nicotine and Its Receptors In The Cancer Contextmentioning

confidence: 99%

Nicotinic Acetylcholine Receptors as Potential Tumor Biomarkers in Genitourinary Cancers: a Review Study

et al. 2021

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The genitourinary tissues express the different subtypes of nicotinic acetylcholine receptors (nAChRs), which are involved in many physiologic and pathologic processes. New studies have indicated the significant role of nAChRs in multiple tumor-related properties in different types of malignancies. Genitourinary cancers (GUCs) represent a heterogeneous population of cancers, in both histology and approach to treatment. nAChRs are functionally expressed by a variety of immune cells, tumor cells, and tumor-associated cells in the microenvironment of GUCs. In the current review study, publications until May 2021 were included in the literature review to summarize the potential effects and clinical and experimental significance of nAChRs in GUCs pathogenesis. The results yielded substantial and some paradoxical evidence regard the role of different subtypes of nAChRs as potential regulators and predictive biomarkers for GUCs. The accumulated evidence demonstrated that nAChRs levels were increased in the GUCs samples, which provides clinically relevant information on utilizing nAChRs as a new biomarker to improve the prognosis of these cancers. Also, activation or blockade of these receptors may lead to different downstream signaling pathways and cause diverse effects. Regarding the significant global burden of GUCs, evaluation of these receptors and delineating their molecular mechanisms could enrich our understanding of the biology of GUCs and may have new opportunities for clinical impacts.

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Section: Nicotine and Its Receptors In The Cancer Contextmentioning

confidence: 99%

Nicotinic Acetylcholine Receptors as Potential Tumor Biomarkers in Genitourinary Cancers: a Review Study

et al. 2021

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“…Similar associations were also observed by Hart et al [6] and Hart and Madan [7] in separate studies based on their observations. Some recent studies include the role of mustard oil and nicotine in gallbladder carcinoma [8,9].…”

Section: Introductionmentioning

confidence: 99%

A Bayes Study of Bile Acid Constituents on Cholelithiasis and Carcinoma of the Gallbladder

Srivastava¹

2014

Int. J. Stats. Med. Res.

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Background: Significantly high concentration of secondary bile acids and low concentration of primary acids are reported by the surgeons in patients with gallbladder carcinoma (GBC) compared to control and cholelithiasis groups.Aim: To examine the effect of primary and secondary bile acids on the development of cholelithiasis and GBC and to investigate the association, if any, among the two groups of bile acids. Methods:The study uses two groups of patients at a time selected in accordance with some pre-fixed inclusion and exclusion criteria. Informed consent was obtained from all patients. The demographic characteristics such as mean age, sex ratio and body mass index, etc. are obtained for the selected groups of patients. The study defines dichotomous responses and the four bile acid constituents, namely cholic acid (CA), chenodeoxycholic acid (CDCA), deoxycholic acid (DCA) and lithocholic acid (LCA), as the predictors. It then assumes logistic regression model to associate the binary responses with the predictors by using probability scores. Bayes analysis is developed using Markov chain Monte Carlo (MCMC) pack in R software for the posterior simulation.Results: Twenty one cholelithiasis patients and twenty patients in each of control and GBC groups are studied. It is seen that a unit decrement in the level of CA (CDCA) increases the log (odds ratio) for cholelithiasis by an amount of 0.49 (0.14) and odds ratio by almost 1 .5 (1.12). Similarly, a unit increment in the level of DCA (LCA) provides the log (odds ratio) for cholelithiasis as 0.18 (1.3) and odds ratio as 1.16 (2.95). Comparing GBC with control population, it is noted that a unit decrease in the level of CA (CDCA) in the control population increases the log (odds ratio) for GBC by an amount of 1.16(0.26) and odds ratio by almost 2.63 (1.24) times. Similarly, the log(odds ratio) for GBC increases by 0.77(1.94) and the odds ratio increases by 1.9 (5.0) for the unit increment in the level of DCA(LCA). Conclusions:The study observes relatively high variations in the primary and secondary bile acids in the cholelithiasis and GBC groups as compared with the control group. It, in turn, reflects strong association among the two categories of bile acids in gallbladder diseases.

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Why Is Gallbladder Cancer Common in the Gangetic Belt?

Dixit

Shukla

2013

Perspectives in Cancer Prevention-Translational Cancer Research

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Role of nicotine in gallbladder carcinoma: A preliminary report

Abstract: Nicotine is selectively concentrated in malignant gallbladder tissue irrespective of smoking status, showing its strong association with gallbladder cancer.

Cited by 7 publications

References 25 publications

Nicotinic Acetylcholine Receptors as Potential Tumor Biomarkers in Genitourinary Cancers: a Review Study

Nicotinic Acetylcholine Receptors as Potential Tumor Biomarkers in Genitourinary Cancers: a Review Study

A Bayes Study of Bile Acid Constituents on Cholelithiasis and Carcinoma of the Gallbladder

Why Is Gallbladder Cancer Common in the Gangetic Belt?

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