Role of nitric oxide/cyclic GMP/K+ channel pathways in the antinociceptive effect caused by 2,3-bis(mesitylseleno)propenol

Jessé, Cristiano Ricardo; Savegnago, Lucielli; Nogueira, Cristina W.

doi:10.1016/j.lfs.2007.10.010

Cited by 35 publications

(18 citation statements)

References 51 publications

(68 reference statements)

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“…These findings are supported by numerous studies that determined reversion of antinociception after inhibition of the NO/ C GMP/K ATP pathway (Ortiz et al 2003;Jesse et al 2007;Hernández-Pacheco et al 2008).…”

Section: Discussionsupporting

confidence: 60%

Involvement of the nitric oxide/CGMP/KATP pathway in antinociception induced by exercise in rats

et al. 2010

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Section: Discussionsupporting

confidence: 60%

Involvement of the nitric oxide/CGMP/KATP pathway in antinociception induced by exercise in rats

et al. 2010

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“…Intraplantar injection of glutamate into the mouse hindpaw produces nociceptive-like behaviors of rapid onset and short duration (about 15 min). As well as, other organoselenium compounds (Jesse et al, 2007Pavin et al, 2011;Pinto et al, 2008;Savegnago et al, 2007a,c;Wilhelm et al, 2009), the BMD reduced the nociceptive response induced by glutamate in mice. Of note, aspirin and acetaminophen demonstrated an antinociceptive effect in the glutamate test (Choi et al, 2001).…”

Section: Discussionmentioning

confidence: 89%

“…Recently, our group of research showed hepatoprotective effect of bis(4-methylbenzoyl) diselenide (BMD), an disubstituted diaryl diselenide, against carbon tetrachloride (CCl 4 )-induced oxidative damage in mice possibly by modulating the antioxidant status (Filho et al, 2013). Moreover, in previous publications, the antinociceptive and anti-inflammatory properties of organoselenium compounds were reported (Jesse et al, 2007(Jesse et al, , 2009aLuchese et al, 2010;Savegnago et al, 2006Savegnago et al, , 2007aPinto et al, 2008;Wilhelm et al, 2009;Pavin et al, 2011) which are potentially useful drugs for pain management.…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive and anti-hyperalgesic effects of bis(4-methylbenzoyl) diselenide in mice: Evidence for the mechanism of action

Donato

Pavin

Goes

et al. 2014

Pharmaceutical Biology

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(2015) Antinociceptive and anti-hyperalgesic effects of bis(4-methylbenzoyl) diselenide in mice: Evidence for the mechanism of action, Pharmaceutical Biology, 53:3, 395-403, DOI: 10.3109/13880209.2014 -nitro-L-arginine ( L-NOARG), but the effect of BMD was not abolished by naloxone. Mechanical hyperalgesia induced by Cg and CFA was attenuated by BMD, 70 ± 4% and 65 ± 4%, respectively. Furthermore, a single oral dose of BMD did not change plasma aspartate (AST) and alanine aminotransferase (ALT) activities or urea and creatinine levels. Conclusion: BMD demonstrated as a promising compound because of the antinociceptive and anti-hyperalgesic properties in mice.

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“…There have been many reports that glibenclamide specifically blocks the ATP-sensitive K + channel, with no effects on other types of K + channel such as Ca 2+ -activated K + channel and voltage-gated potassium channels (Alves & Duarte, 2002;Jesse et al, 2007;Lazaro-Ibanez et al, 2001). In the present study, we analyzed only the participation of the K + ATP channel, but we cannot disregard the possible participation of other K + channels in the antinociceptive effect of MS.…”

Section: Discussionmentioning

confidence: 97%

The antinociceptive effects of magnesium sulfate and MK-801 in visceral inflammatory pain model: The role of NO/cGMP/K⁺ATP pathway

Vučković

Srebro

Vujović

et al. 2015

Pharmaceutical Biology

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Context: Magnesium and MK-801 (dizocilpine), antagonists of N-methyl-D-aspartate receptors, are involved in the processing of pain. Objective: This study determines whether magnesium sulfate (MS) and MK-801 affects visceral inflammatory pain and determines a possible mechanism of action. Materials and methods: Analgesic activity was assessed using the acetic acid-induced writhing test in rats. MS (1-45 mg/kg) or MK-801 (0.005-0.03 mg/kg) was administrated subcutaneously (s.c.). To assess possible mechanisms of action, we examined the effects of L-NAME (10 mg/kg, intraperitoneal), methylene blue (0.5 mg/kg, s.c.), and glibenclamide (3 mg/kg, s.c.) on the effect of MS or MK-801. Results: MS and MK-801 showed biphasic and linear dose-response pattern, respectively. MS reduces the number of writhing on the dose of 1, 5, and 15 mg/kg by 60, 50, and 78%, respectively, while it has no effects on the doses of 30 and 45 mg/kg. MK-801 (0.005-0.03 mg/kg) showed decrease in the number of writhing by 33-79%. The mean effective doses of MS and MK-801 were 6.6 (first phase) and 0.009 mg/kg, respectively. Both drugs did not impair the rotarod performance. L-NAME, methylene blue, and glybenclamide reduced the effect of MK-801 by 100, 43, and 64%, respectively, but not the effect of MS. Conclusions:The results suggest that MS and MK-801 may be useful analgesics in the management of visceral inflammatory pain, at doses that do not induce motor impairment. The modulation of NO/cGMP/K+ATP pathway plays an important role in the antinociceptive mechanism of MK-801, but does not contribute to the antinociceptive effect of MS.

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Role of nitric oxide/cyclic GMP/K+ channel pathways in the antinociceptive effect caused by 2,3-bis(mesitylseleno)propenol

Cited by 35 publications

References 51 publications

Involvement of the nitric oxide/CGMP/KATP pathway in antinociception induced by exercise in rats

Involvement of the nitric oxide/CGMP/KATP pathway in antinociception induced by exercise in rats

Antinociceptive and anti-hyperalgesic effects of bis(4-methylbenzoyl) diselenide in mice: Evidence for the mechanism of action

The antinociceptive effects of magnesium sulfate and MK-801 in visceral inflammatory pain model: The role of NO/cGMP/K⁺ATP pathway

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Role of nitric oxide/cyclic GMP/K+ channel pathways in the antinociceptive effect caused by 2,3-bis(mesitylseleno)propenol

Cited by 35 publications

References 51 publications

Involvement of the nitric oxide/CGMP/KATP pathway in antinociception induced by exercise in rats

Involvement of the nitric oxide/CGMP/KATP pathway in antinociception induced by exercise in rats

Antinociceptive and anti-hyperalgesic effects of bis(4-methylbenzoyl) diselenide in mice: Evidence for the mechanism of action

The antinociceptive effects of magnesium sulfate and MK-801 in visceral inflammatory pain model: The role of NO/cGMP/K+ATP pathway

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The antinociceptive effects of magnesium sulfate and MK-801 in visceral inflammatory pain model: The role of NO/cGMP/K⁺ATP pathway