Role of nitric oxide in the regulation of digital pulse volume amplitude in humans

Nohria, Anju; Gerhard‐Herman, Marie; Creager, Mark A.; Hurley, Shauna; Mitra, Debi; Ganz, Patricia A.

doi:10.1152/japplphysiol.01285.2005

Cited by 405 publications

(347 citation statements)

References 21 publications

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“…11,12) Because this index mainly reflects NO-dependent vasodilation, 17) our results suggest that one round of stretching exercises increased NO production from vascular endothelial cells in AMI patients. Awolesi, et al showed upregulation of eNOS mRNA expression in bovine vascular endothelial cells subjected to cyclic stretch stimuli for 15 minutes and increased eNOS translation with 24-hour cyclic stretch stimuli.…”

Section: Discussionmentioning

confidence: 72%

Stretching Exercises Enhance Vascular Endothelial Function and Improve Peripheral Circulation in Patients With Acute Myocardial Infarction

et al. 2013

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SummaryThe purpose of this study was to clarify the acute effects of a single session of stretching exercises on vascular endothelial function and peripheral circulation in patients with acute myocardial infarction. This study evaluated 32 patients (mean age, 66 ± 9 years) who received phase I cardiac rehabilitation after acute myocardial infarction. Five types of stretching exercises were performed on the floor: wrist dorsiflexion, close-legged trunk flexion, open-legged trunk flexion, open-legged lateral trunk bending, and cross-legged trunk flexion. Each exercise entailed a 30-second stretching followed by a 30-second relaxation, and was repeated twice. Low-and high-frequency components (LF and HF) of heart rate variability (LF, 0.04-0.15 Hz; HF, 0.15-0.40 Hz) were analyzed, and HF and LF/HF were used as indices of parasympathetic and sympathetic nervous activities, respectively. Reactive hyperemia peripheral arterial tonometry (RH-PAT) index was measured and used as a parameter for vascular endothelial function. Transcutaneous oxygen pressure (tcPO 2 ) on the right foot and chest was also measured, and the Foot-tcPO 2 /Chest-tcPO 2 ratio was used as a parameter for peripheral circulation. The HF, RH-PAT index, and Foot-tcPO 2 /Chest-tcPO 2 ratio were significantly higher after the exercises than before (P < 0.05, P < 0.01, and P < 0.05, respectively). There was no significant difference in the LF/HF ratio measured before and after stretching exercises. These findings demonstrate that stretching exercises improve vascular endothelial function and peripheral circulation in patients with acute myocardial infarction. (Int Heart J 2013; 54: 59-63)

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Section: Discussionmentioning

confidence: 72%

Stretching Exercises Enhance Vascular Endothelial Function and Improve Peripheral Circulation in Patients With Acute Myocardial Infarction

et al. 2013

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“…The peripheral vascular bed at distal limbs is the major site of sympathetic α-adrenergic vasoconstrictor activity [50,51]. The use of the specific NO antagonist L-NMMA has defined the contribution of NO to these vasomotor responses: Approximately 60% of the PAT response is mediated by NO release [52,53]; the rest is probably mediated by the autonomous nervous system.…”

Section: How Can We Measure Endothelial Function?mentioning

confidence: 99%

Endothelial dysfunction in cardiovascular disease and Flammer syndrome—similarities and differences

et al. 2017

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The endothelium has increasingly been recognized as a smart barrier and a key regulator of blood flow in microand macrovascular beds. Endothelial dysfunction marks a stage of atherosclerosis and is an important prognostic marker for cardiovascular disease. Yet, some people who tend to be slim and physically active and with rather low blood pressure show a propensity to respond to certain stimuli such as emotional stress with endothelial-mediated vascular dysregulation (Flammer syndrome). This leads to characteristic vascular symptoms such as cold hands but also a risk for vascularmediated diseases such as normal-tension glaucoma. It is the aim of this review to delineate the differences between Flammer syndrome and its Bcounterpart^endothelial dysfunction in the context of cardiovascular diseases.

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“…Recently, finger plethysmography peripheral arterial tonometry has also been used. 42,43 Circulating levels of nitrite/nitrate, cyclic guanosine 3 0 ,5 0 -monophosphate, vascular cell adhesion molecule-1, intracellular adhesion molecule-1, monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, von Willebrand factor, asymmetrical dimethylarginine, endothelial microparticles and progenitor cells are also measured as indices of endothelial function. 21,[44][45][46][47] However, these measurements do not directly reflect the production of NO from endothelial cells and are not 'function' .…”

Section: Endothelial Functionmentioning

confidence: 99%

Endothelial dysfunction and hypertension in aging

2012

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Hypertension is one of the common diseases in the elderly. The prevalence of hypertension markedly increases with advancing age. Both aging and hypertension have a critical role in cardiovascular and cerebrovascular complications. Although aging and hypertension, either independently or collectively, impair endothelial function, aging and hypertension may have similar cascades for the pathogenesis and development of endothelial dysfunction. Nitric oxide (NO) has an important role in regulation of vascular tone. Decrease in NO bioavailability by endothelial dysfunction would lead to elevation of blood pressure. An imbalance of reduced production of NO or increased production of reactive oxygen species, mainly superoxide, may promote endothelial dysfunction. One possible mechanism by which the prevalence of hypertension is increased in relation to aging may be advancing endothelial dysfunction associated with aging through an increase in oxidative stress. In addition, endothelial cell senescence is also involved in aging-related endothelial dysfunction. In this review, we focus on recent findings and interactions between endothelial function, oxidative stress and hypertension in aging.

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Role of nitric oxide in the regulation of digital pulse volume amplitude in humans

Abstract: . Role of nitric oxide in the regulation of digital pulse volume amplitude in humans.

Cited by 405 publications

References 21 publications

Stretching Exercises Enhance Vascular Endothelial Function and Improve Peripheral Circulation in Patients With Acute Myocardial Infarction

Stretching Exercises Enhance Vascular Endothelial Function and Improve Peripheral Circulation in Patients With Acute Myocardial Infarction

Endothelial dysfunction in cardiovascular disease and Flammer syndrome—similarities and differences

Endothelial dysfunction and hypertension in aging

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