2003
DOI: 10.1016/s1089-8603(02)00182-9
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Role of nitric oxide in d-galactosamine-induced cell death and its protection by PGE1 in cultured hepatocytes

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Cited by 32 publications
(37 citation statements)
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“…Recently, we reported the role of NF-B in D-GalN-induced hepatotoxicity and its protection by PGE 1 . 31,35 In these studies, we observed that although NF-B expression in the nuclear fraction of control hepatocytes varied among cultures, the profile of NF-B activation did not change. PGE 1 administration to hepatocytes induced a rapid NF-B translocation (0-1 hour).…”
Section: Resultsmentioning
confidence: 78%
See 1 more Smart Citation
“…Recently, we reported the role of NF-B in D-GalN-induced hepatotoxicity and its protection by PGE 1 . 31,35 In these studies, we observed that although NF-B expression in the nuclear fraction of control hepatocytes varied among cultures, the profile of NF-B activation did not change. PGE 1 administration to hepatocytes induced a rapid NF-B translocation (0-1 hour).…”
Section: Resultsmentioning
confidence: 78%
“…30 Nevertheless, the inhibition of NOS-2 revealed that early NO production also mediates the protection by PGE 1 preadministration against D-GalN-induced apoptosis. 31 The aim of the present study was to elucidate the mechanisms through which PGE 1 is able to regulate the cell death induced by D-GalN and whether initial synthesis of NO induced by PGE 1 can exert a negative feedback regulation of NOS-2 expression and NO produced after D-GalN challenge.…”
mentioning
confidence: 99%
“…9,10) Here, we show that L.E.M. protected cultured hepatocytes and the in-vivo liver from GalN-induced injury.…”
mentioning
confidence: 58%
“…On the other hand, hepatocytes have been reportedly killed by exposure to CPT or galactosamine alone. 47,48 These disparities may be caused by contaminating activated Kupffer cells in the hepatocyte culture or due to the activation of liver-resident Kupffer cells producing TNF during the liver perfusion. We therefore purified the hepatocytes using a multistep Percoll gradient, 49 a method that excludes any macrophage contamination.…”
Section: Discussionmentioning
confidence: 99%