Role of nitric oxide in HIV-1 infection: friend or foe?

Torre, Donato; Pugliese, A.; Speranza, Filippo

doi:10.1016/s1473-3099(02)00262-1

Cited by 101 publications

(65 citation statements)

References 64 publications

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“…We present evidence that immune activation, as assessed by increased frequencies of Ki67 ϩ and CCR5 ϩ CD4 ϩ T cells, and also by elevated systemic levels of NO and proinflammatory cytokines, is induced by P. fragile and is associated with a transient increase in viremia. We hypothesize that increased numbers of CCR5 ϩ CD4 ϩ T cells translate into higher numbers of target cells for the virus and that NO, through the activation of NF-B, can directly induce HIV replication in virally infected cells (6,39,40,51). In addition to affecting immune activation at this acute time point, we postulate that coinfected animals may experience heightened activation in the longer term that could promote earlier immune exhaustion and onset to simian AIDS.…”

Section: Discussionmentioning

confidence: 98%

Evidence for an Increased Risk of Transmission of Simian Immunodeficiency Virus and Malaria in a Rhesus Macaque Coinfection Model

Trott

Chau

Hudgens

et al. 2011

J Virol

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In sub-Saharan Africa, HIV-1 infection frequently occurs in the context of other coinfecting pathogens, most importantly, Mycobacterium tuberculosis and malaria parasites. The consequences are often devastating, resulting in enhanced morbidity and mortality. Due to the large number of confounding factors influencing pathogenesis in coinfected people, we sought to develop a nonhuman primate model of simian immunodeficiency virus (SIV)-malaria coinfection. In sub-Saharan Africa, Plasmodium falciparum is the most common malaria parasite and is responsible for most malaria-induced deaths. The simian malaria parasite Plasmodium fragile can induce clinical symptoms, including cerebral malaria in rhesus macaques, that resemble those of P. falciparum infection in humans. Thus, based on the well-characterized rhesus macaque model of SIV infection, this study reports the development of a novel rhesus macaque SIV-P. fragile coinfection model to study human HIV-P. falciparum coinfection. Using this model, we show that coinfection is associated with an increased, although transient, risk of both HIV and malaria transmission. Specifically, SIV-P. fragile coinfected macaques experienced an increase in SIV viremia that was temporarily associated with an increase in potential SIV target cells and systemic immune activation during acute parasitemia. Conversely, primary parasitemia in SIV-P. fragile coinfected animals resulted in higher gametocytemia that subsequently translated into higher oocyst development in mosquitoes. To our knowledge, this is the first animal model able to recapitulate the increased transmission risk of both HIV and malaria in coinfected humans. Therefore, this model could serve as an essential tool to elucidate distinct immunological, virological, and/or parasitological parameters underlying disease exacerbation in HIV-malaria coinfected people.

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Section: Discussionmentioning

confidence: 98%

Evidence for an Increased Risk of Transmission of Simian Immunodeficiency Virus and Malaria in a Rhesus Macaque Coinfection Model

Trott

Chau

Hudgens

et al. 2011

J Virol

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“…Nitric oxide (NO) metabolites, nitrite and nitrate, were identified in various honeys [41] . NO has antiviral effects against the DNA and RNA of several viruses [42] . There is some evidence of NO activity directly or indirectly blocking HIV-1 replication [42] .…”

Section: Anti-inflammatory and Antiviral Effects Of Honeymentioning

confidence: 99%

Medical honey and the role in pediatric emergency wound management

Bittmann

Weissenstein²,

Villalon³

et al. 2018

J Pediatr Dis

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The use of complementary medical treatment in wound management has continued to grow throughout the world.There is a large body of evidence to support the use of honey as a wound dressing for a wide range of types of wounds.Clear guidelines for the use of honey in pediatric wound care do not exist. We present an update of present knowledge using honey as a form of complementary medicine in pediatric wound management.

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“…NO-induced oxidative stress leading to rapid viral evolution with the production of drug-resistant and immunologically tolerant mutants has also been described [10]. Thus, L-arginine may be beneficial or harmful to the body and the question of its safety could be related to the dose administered.…”

Section: Active Ingredients Of Sutherlandiamentioning

confidence: 99%

Spotlight on Ethnomedicine: Usability of Sutherlandia Frutescens in the Treatment of Diabetes

Sia

2004

Rev Diab Stud

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Role of nitric oxide in HIV-1 infection: friend or foe?

Cited by 101 publications

References 64 publications

Evidence for an Increased Risk of Transmission of Simian Immunodeficiency Virus and Malaria in a Rhesus Macaque Coinfection Model

Evidence for an Increased Risk of Transmission of Simian Immunodeficiency Virus and Malaria in a Rhesus Macaque Coinfection Model

Medical honey and the role in pediatric emergency wound management

Spotlight on Ethnomedicine: Usability of Sutherlandia Frutescens in the Treatment of Diabetes

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