Role of nitric oxide in obsessive–compulsive behavior and its involvement in the anti-compulsive effect of paroxetine in mice

Role of nitric oxide in amphetamine-induced sensitization of schedule-induced polydipsic rats

“…Such agents might be particularly well suited to treat compulsive behaviors associated with chronic stress. In terms of modeling OCD, the ability of L-NAME to prevent AMPH sensitization demonstrated in the present study was consistent with evidence that NO appeared crucially relevant to the pathophysiology of OCD in both human and animal studies (Atmaca et al 2005;Umathe et al 2009). Our results also support the potential use of AMPHlike psychostimulants as an adjunctive pharmacological treatment for OCD patients (Koran et al 2009).…”

“…It is important to determine which of these mechanisms underlies the AMPH sensitization in SIP. Second, increasing evidence in recent years has suggested that NO is relevant to OCD pathogenesis (Atmaca et al 2005;Umathe et al 2009). Thus, the role of NO in SIP is worth exploring if SIP is used to model OCD.…”

Switching to zebrafish neurobehavioral models: The obsessive–compulsive disorder paradigm

“…It shows a 5-HT1a receptor involvement (serotonin system), modulation by sex steroids and response to fluoxetine (Estrada-Camarena et al, 2006;Umathe et al, 2009). However, the predictive validity of the model regarding HFS has not been proven.…”

Participação da via NMDA-NO do córtex pré-frontal medial ventral na modulação das consequências comportamentais do estresse de nado forçado: mecanismos intracelulares

“…Several pieces of evidence indicate the involvement of glutamate/NO neurotransmission in OCD (Aboujaoude et al, 2009;Egashira et al, 2008;Grant et al, 2007). Anti-glutamatergic drugs (Iijima et al, 2010) or NO synthase inhibitors Umathe et al, 2009) reduce the number of buried marbles in this test, an anticompulsive-like effect. Since the purinergic and glutamatergic systems interact (Cho et al, 2010;Inoue et al, 1992;Khakh, 2009;Khakh and Henderson, 1998), we investigated whether the blockade of purinergic transmission would decrease repetitive behavior in MBT by impairing glutamatergic/nitrergic transmission.…”

“…Considering that NOS inhibitors, as well as antidepressants that block serotonin reuptake, present anticompulsive properties Umathe et al, 2009), we also studied if PR2 blockade would induce anti-compulsive-like effects. Initially, we verified the effects of the non-selective P2R antagonist, PPADS, in animals exposed to forced swimming (FST), elevated plus maze (EPM) or marble burying (MBT) tests.…”