1997
DOI: 10.1016/s0928-4257(97)89477-6
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Role of nitric oxide in pathogenesis of gastric mucosal damage induced by compound in rats

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Cited by 25 publications
(6 citation statements)
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“…Moreover, cimetidine has been found to have no preventive effect against the lesion development in both models. The increase in free radical nitric oxide (peroxynitrite) production by iNOS has also been found to be associated with the development of lesions as well [22]. In the present study, the beneficial effect of aminoguanidine against the development of lesions in both models confirms the important role of iNOS in enhancing lesion progression.…”
Section: Discussionsupporting
confidence: 81%
“…Moreover, cimetidine has been found to have no preventive effect against the lesion development in both models. The increase in free radical nitric oxide (peroxynitrite) production by iNOS has also been found to be associated with the development of lesions as well [22]. In the present study, the beneficial effect of aminoguanidine against the development of lesions in both models confirms the important role of iNOS in enhancing lesion progression.…”
Section: Discussionsupporting
confidence: 81%
“…Increased mucosal iNOS, reduced cNOS, and augmented nitrite/nitrate levels in the lumen are common features of the damage induced by other deleterious agents such as NSAIDs (Piotrowski et al, 1999), mast cell degranulation (Yasuhiro et al, 1997a), serotonine (Yasuhiro et al, 1997b), or cigarette smoke (Chow et al, 1998). Inhibition of iNOS reduces the level of gastric damage in many of these experimental models of injury (Chow et al, 1998;Nishida et al, 1998b;Yasuhiro et al, 1997a,b), thus confirming the deleterious effect of the massive release of NO.…”
Section: Nitric Oxide and Gastricmentioning
confidence: 84%
“…Although NO is considered to be important in maintaining gastric mucosal integrity, recent studies also showed a detrimental role for NO in inflammatory gastrointestinal disorders; thus some of the mechanisms that have been proposed to explain the increase in NO in other experimental studies may be operating in the gastric mucosa after NSAID administration (51)(52)(53)(54)(55).…”
Section: Figmentioning
confidence: 99%