Role of NK Cells in Tumor Progression

Terrén, Íñigo; Borrego, Francisco Javier Escobar

doi:10.1007/978-3-030-91311-3_6

Cited by 4 publications

(7 citation statements)

References 128 publications

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“…KLRK1 is essential for enabling NK cells to activate, recognize, and eliminate tumor cells by interacting with stress-induced ligands on transformed cells [36]. This interaction is vital for triggering NK cells to attack and destroy tumor cells, a crucial mechanism for controlling tumor growth and promoting tumor regression [37, 38]. The NK_CD56bri_CXCR6 subtype is notable for its expression of cytokine genes such as CXCR6 , CCL4 , CCL4L2 , CCL3 , and CCL3L1 .…”

Section: Resultsmentioning

confidence: 99%

“…KLRK1 , also known as NKG2D, serves as a critical activating receptor on NK cells. This receptor plays a pivotal role in mediating immune responses, recognizing stress ligands frequently upregulated in cancer cells due to cellular stress or transformation [37]. The interaction between KLRK1 and these ligands prompts NK cells to attack and destroy tumor cells, a vital process in controlling tumor growth and promoting regression [37, 38].…”

Section: Discussionmentioning

confidence: 99%

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Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in Glioblastoma

Cheng,

Yan,

Zhang

et al. 2024

Preprint

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Glioblastoma (GBM) is the most prevalent and aggressive primary brain malignancy in adults. Nevertheless, the cellular heterogeneity and complexity within the GBM microenvironment (TME) are still not fully understood, posing a significant obstacle in the advancement of more efficient immunotherapies for GBM. In this study, we conducted an integrated analysis of 48 tumor fragments from 24 GBM patients at the single-cell level, uncovering substantial molecular diversity within immune infiltrates. We characterized molecular signatures for five distinct tumor-associated macrophage (TAM) subtypes. Notably, the TAM_MRC1 subtype displayed a pronounced M2 polarization signature. Additionally, we identified a subtype of natural killer (NK) cells, designated CD56dim_DNAJB1. This subtype is characterized by an exhausted phenotype, evidenced by an elevated stress signature and enrichment in the PD-L1/PD-1 checkpoint pathway. Our findings also highlight significant cell-cell interactions among malignant glioma cells, TAM, and NK cells within the TME. Overall, this research sheds light on the functional heterogeneity of glioma and immune cells in the TME, providing potential targets for therapeutic intervention in this immunologically cold cancer.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in Glioblastoma

Cheng,

Yan,

Zhang

et al. 2024

Preprint

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“…KLRK1, also known as NKG2D, serves as a critical activating receptor on NK cells. This receptor plays a pivotal role in mediating immune responses, recognizing stress ligands frequently upregulated in cancer cells due to cellular stress or transformation (Terrén and Borrego, 2022). The interaction between KLRK1 and these ligands prompts NK cells to attack and destroy tumor cells, a vital process in controlling tumor growth and promoting regression (Terrén and Borrego, 2022;Wang et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…This receptor plays a pivotal role in mediating immune responses, recognizing stress ligands frequently upregulated in cancer cells due to cellular stress or transformation (Terrén and Borrego, 2022). The interaction between KLRK1 and these ligands prompts NK cells to attack and destroy tumor cells, a vital process in controlling tumor growth and promoting regression (Terrén and Borrego, 2022;Wang et al, 2021). Additionally, the activation of KLRK1 is essential for the effective in ltration and activity of NK cells in tumors, as evidenced by studies showing enhanced NK cell in ltration and activation in tumor tissues following lenvatinib treatment (Zhang et al, 2019b).…”

Section: Discussionmentioning

confidence: 99%

“…KLRK1 is essential for enabling NK cells to activate, recognize, and eliminate tumor cells by interacting with stress-induced ligands on transformed cells (Wilton et al, 2019). This interaction is vital for triggering NK cells to attack and destroy tumor cells, a crucial mechanism for controlling tumor growth and promoting tumor regression (Terrén and Borrego, 2022;Wang et al, 2021). The NK_CD56bri_CXCR6 subtype is notable for its expression of cytokine genes such as CXCR6, CCL4, CCL4L2, CCL3, and CCL3L1.…”

Section: Detailed Analysis Of Nk Cells Uncovering Cd56dim_dnajb1 Dysf...mentioning

confidence: 99%

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Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in Glioblastoma

Cheng,

Yan,

Zhang

et al. 2024

Preprint

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Purpose Glioblastoma (GBM) is the most prevalent and aggressive primary brain malignancy in adults. Nevertheless, the cellular heterogeneity and complexity within the GBM microenvironment (TME) are still not fully understood, posing a significant obstacle in the advancement of more efficient immunotherapies for GBM. Methods In this study, we conducted an integrated analysis of 48 tumor fragments from 24 GBM patients at the single-cell level, uncovering substantial molecular diversity within immune infiltrates. Results We characterized molecular signatures for five distinct tumor-associated macrophage (TAM) subtypes. Notably, the TAM_MRC1 subtype displayed a pronounced M2 polarization signature. Additionally, we identified a subtype of natural killer (NK) cells, designated CD56dim_DNAJB1. This subtype is characterized by an exhausted phenotype, evidenced by an elevated stress signature and enrichment in the PD-L1/PD-1 checkpoint pathway. Our findings also highlight significant cell-cell interactions among malignant glioma cells, TAM, and NK cells within the TME. Conclusion This research sheds light on the functional heterogeneity of glioma and immune cells in the TME, providing potential targets for therapeutic intervention in this immunologically cold cancer.

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In vivo expansion of a CD9+ decidual-like NK cell subset following autologous hematopoietic stem cell transplantation

Orrantia¹,

Luis²,

Astarloa-Pando³

et al. 2022

iScience

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Role of NK Cells in Tumor Progression

Cited by 4 publications

References 128 publications

Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in Glioblastoma

Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in Glioblastoma

Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in Glioblastoma

In vivo expansion of a CD9+ decidual-like NK cell subset following autologous hematopoietic stem cell transplantation

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