Role of NLRP3 inflammasome in nanoparticle adjuvant-mediated immune response

Ahmed, Momitul; Kurungottu, Pavithra; Swetha, K.; Atla, Sandeep; Ashok, Nivethitha; Nagamalleswari, Easa; Bonam, Srinivasa Reddy; Sahu, Bidya Dhar; Kurapati, Rajendra

doi:10.1039/d4bm00439f

Biomater. Sci.

2025

DOI: 10.1039/d4bm00439f

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Role of NLRP3 inflammasome in nanoparticle adjuvant-mediated immune response

Momitul Ahmed,

Pavithra Kurungottu,

K. Swetha

et al.

Abstract: The NLRP3 inflammasome is pivotal in orchestrating the immune response induced by nanoparticle adjuvants. Understanding the intricate mechanisms underlying the activation of NLRP3 inflammasome by these adjuvants is crucial for...

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Current Advances in Nanomaterials Affecting Functions and Morphology of Platelets

Peng,

Sun,

Zhao

et al. 2024

JFB

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Nanomaterials have been extensively used in the biomedical field due to their unique physical and chemical properties. They promise wide applications in the diagnosis, prevention, and treatment of diseases. Nanodrugs are generally transported to target tissues or organs by coupling targeting molecules or enhanced permeability and retention effect (EPR) passively. As intravenous injection is the most common means of administration of nanomedicine, the transport process inevitably involves the interactions between nanoparticles (NPs) and blood cells. Platelets are known to not only play a critical role in normal coagulation by performing adhesion, aggregation, release, and contraction functions, but also be associated with pathological thrombosis, tumor metastasis, inflammation, and immune reactions, making it necessary to investigate the effects of NPs on platelet function during transport, particularly the way in which their physical and chemical properties determine their interaction with platelets and the underlying mechanisms by which they activate and induce platelet aggregation. However, such data are lacking. This review is intended to summarize the effects of NPs on platelet activation, aggregation, release, and apoptosis, as well as their effects on membrane proteins and morphology in order to shed light on such key issues as how to reduce their adverse reactions in the blood system, which should be taken into consideration in NP engineering.

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Current Advances in Nanomaterials Affecting Functions and Morphology of Platelets

Peng,

Sun,

Zhao

et al. 2024

JFB

View full text Add to dashboard Cite

show abstract

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Role of NLRP3 inflammasome in nanoparticle adjuvant-mediated immune response

Abstract: The NLRP3 inflammasome is pivotal in orchestrating the immune response induced by nanoparticle adjuvants. Understanding the intricate mechanisms underlying the activation of NLRP3 inflammasome by these adjuvants is crucial for...

Cited by 1 publication

References 128 publications

Current Advances in Nanomaterials Affecting Functions and Morphology of Platelets

Current Advances in Nanomaterials Affecting Functions and Morphology of Platelets

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