Role of NMDA Receptor in High-Pressure Neurological Syndrome and Hyperbaric Oxygen Toxicity

Bliznyuk, Alice; Grossman, Yoram

doi:10.3390/biom13121786

Cited by 2 publications

(1 citation statement)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lipid tail inclusions in "fenestrations" at the interface between the transmembrane helices in channels that potentially expose the ion conduction pathway to the lipid core of the bilayer can also be modulated by HP/GA [69,70]. Regarding the diffusive nature of the helium phase, it can inflict molecular distortions alongside conformational uncertainty and likely impedes precise docking interactions for guided ligand molecules in the extramembrane protein domain [71]. Meanwhile, enhanced hydrophobic gating in the lipid membrane saturated with helium might be an additional cause for the induced hyperexcitability.…”

Section: Discussionmentioning

confidence: 99%

Studying the Effects of Dissolved Noble Gases and High Hydrostatic Pressure on the Spherical DOPC Bilayer Using Molecular Dynamic Simulations

Pavlyuk,

Yungerman,

Bliznyuk

et al. 2024

Membranes

Self Cite

View full text Add to dashboard Cite

Fine-grained molecular dynamics simulations have been conducted to depict lipid objects enclosed in water and interacting with a series of noble gases dissolved in the medium. The simple point-charge (SPC) water system, featuring a boundary composed of 1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC) molecules, maintained stability throughout the simulation under standard conditions. This allowed for the accurate modeling of the effects of hydrostatic pressure at an ambient pressure of 25 bar. The chosen pressure references the 240 m depth of seawater: the horizon frequently used by commercial divers, who comprise the primary patient population of the neurological complication of inert gas narcosis and the consequences of high-pressure neurological syndrome. To quantify and validate the neurological effects of noble gases and discriminate them from high hydrostatic pressure, we reduced the dissolved gas molar concentration to 1.5%, three times smaller than what we previously tested for the planar bilayer (3.5%). The nucleation and growth of xenon, argon and neon nanobubbles proved consistent with the data from the planar bilayer simulations. On the other hand, hyperbaric helium induces only a residual distorting effect on the liposome, with no significant condensed gas fraction observed within the hydrophobic core. The bubbles were distributed over a large volume—both in the bulk solvent and in the lipid phase—thereby causing substantial membrane distortion. This finding serves as evidence of the validity of the multisite distortion hypothesis for the neurological effect of inert gases at high pressure.

show abstract

Section: Discussionmentioning

confidence: 99%