Role of Non-Group A Streptococci in Acute Pharyngitis

Tiemstra, Jeffrey D; Miranda, Rosita L F

doi:10.3122/jabfm.2009.06.090035

“…suggested that Lancefield groups C and G presentations were similar to group A; 11 supported by Tiemstra et al 3 Conversely a substantial study concluded that clinical presentations were different. 16 Thus both the relevance of C and G streptococci in symptomatic presentation and the clinical predictors require clarification.…”

Section: Resultsmentioning

confidence: 55%

“…This supports those studies which observed similar symptomatic presentation. 11,3 If group C and G streptococci are clinically important, then rapid streptococcal antigen tests (which are targeted at group A beta-haemolytic streptococci only) will miss a significant proportion of streptococcal infection.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Incidence and clinical variables associated with streptococcal throat infections: a prospective diagnostic cohort study

Little¹,

Hobbs²,

Mant³

et al. 2012

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“…Such a model could potentially be used with computerised practices to document more precisely risk of streptococcal infection (Appendix 4). Although for non-group A streptococci to date we assumed Lancefield groups B and D and also Pneumococcus were not to be counted as significant pharyngeal pathogens ( Tables 2 and 3 and Appendix 4), given the ongoing debates about this issue, 13 we also present the multivariate analysis when these streptococci are included as potentially significant pathogens (see legends to Tables 2 and 3). Given the higher asymptomatic carriage rates of streptococci in children, we did not include age in the final multivariate models.…”

Section: Discussionmentioning

confidence: 99%

“…12,13 Investigating sore throat infections with highly specific RADTs will result in cases of group C and G infections being undiagnosed and untreated. The significance and clinical relevance of this issue will be investigated further in the diagnostic studies (see Chapters 2 and 3).…”

Section: Evaluation Of Five Rapid Antigen Detection Testsmentioning

confidence: 99%

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PRImary care Streptococcal Management (PRISM) study: in vitro study, diagnostic cohorts and a pragmatic adaptive randomised controlled trial with nested qualitative study and cost-effectiveness study

Little

¹

,

Hobbs

²

,

Moore

³

et al. 2014

Health Technol Assess

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Background Antibiotics are still prescribed to most patients attending primary care with acute sore throat, despite evidence that there is modest benefit overall from antibiotics. Targeting antibiotics using either clinical scoring methods or rapid antigen detection tests (RADTs) could help. However, there is debate about which groups of streptococci are important (particularly Lancefield groups C and G), and uncertainty about the variables that most clearly predict the presence of streptococci. Objective This study aimed to compare clinical scores or RADTs with delayed antibiotic prescribing. Design The study comprised a RADT in vitro study; two diagnostic cohorts to develop streptococcal scores (score 1; score 2); and, finally, an open pragmatic randomised controlled trial with nested qualitative and cost-effectiveness studies. Setting The setting was UK primary care general practices. Participants Participants were patients aged ≥ 3 years with acute sore throat. Interventions An internet program randomised patients to targeted antibiotic use according to (1) delayed antibiotics (control group), (2) clinical score or (3) RADT used according to clinical score. Main outcome measures The main outcome measures were self-reported antibiotic use and symptom duration and severity on seven-point Likert scales (primary outcome: mean sore throat/difficulty swallowing score in the first 2–4 days). Results The IMI TestPack Plus Strep A (Inverness Medical, Bedford, UK) was sensitive, specific and easy to use. Lancefield group A/C/G streptococci were found in 40% of cohort 2 and 34% of cohort 1. A five-point score predicting the presence of A/C/G streptococci [FeverPAIN: Fever; Purulence; Attend rapidly (≤ 3 days); severe Inflammation; and No cough or coryza] had moderate predictive value (bootstrapped estimates of area under receiver operating characteristic curve: 0.73 cohort 1, 0.71 cohort 2) and identified a substantial number of participants at low risk of streptococcal infection. In total, 38% of cohort 1 and 36% of cohort 2 scored ≤ 1 for FeverPAIN, associated with streptococcal percentages of 13% and 18%, respectively. In an adaptive trial design, the preliminary score (score 1; n = 1129) was replaced by FeverPAIN (n = 631). For score 1, there were no significant differences between groups. For FeverPAIN, symptom severity was documented in 80% of patients, and was lower in the clinical score group than in the delayed prescribing group (–0.33; 95% confidence interval –0.64 to –0.02; p = 0.039; equivalent to one in three rating sore throat a slight rather than moderately bad problem), and a similar reduction was observed for the RADT group (–0.30; –0.61 to 0.00; p = 0.053). Moderately bad or worse symptoms resolved significantly faster (30%) in the clinical score group (hazard ratio 1.30; 1.03 to 1.63) but not the RADT group (1.11; 0.88 to 1.40). In the delayed group, 75/164 (46%) used antibiotics, and 29% fewer used antibiotics in the clinical score group (risk ratio 0.71; 0.50 to 0.95; p = 0.018) and 27% fewer in the RADT group (0.73; 0.52 to 0.98; p = 0.033). No significant differences in complications or reconsultations were found. The clinical score group dominated both other groups for both the cost/quality-adjusted life-years and cost/change in symptom severity analyses, being both less costly and more effective, and cost-effectiveness acceptability curves indicated the clinical score to be the most likely to be cost-effective from an NHS perspective. Patients were positive about RADTs. Health professionals’ concerns about test validity, the time the test took and medicalising self-limiting illness lessened after using the tests. For both RADTs and clinical scores, there were tensions with established clinical experience. Conclusions Targeting antibiotics using a clinical score (FeverPAIN) efficiently improves symptoms and reduces antibiotic use. RADTs used in combination with FeverPAIN provide no clear advantages over FeverPAIN alone, and RADTs are unlikely to be incorporated into practice until health professionals’ concerns are met and they have experience of using them. Clinical scores also face barriers related to clinicians’ perceptions of their utility in the face of experience. This study has demonstrated the limitation of using one data set to develop a clinical score. FeverPAIN, derived from two data sets, appears to be valid and its use improves outcomes, but diagnostic studies to confirm the validity of FeverPAIN in other data sets and settings are needed. Experienced clinicians need to identify barriers to the use of clinical scoring methods. Implementation studies that address perceived barriers in the use of FeverPAIN are needed. Trial registration Current Controlled Trials ISRCTN32027234. Source of funding This project was funded by the NIHR Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 18, No. 6. See the NIHR Journals Library website for further project information.

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