Role of Novel Hole Technology in Fast Dissolving Tablets

Damodar, Renati; Cv, Vinay

doi:10.4172/2329-9053.1000r1-001

J Mol Pharm Org Process Res

2014

DOI: 10.4172/2329-9053.1000r1-001

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Role of Novel Hole Technology in Fast Dissolving Tablets

Renati Damodar¹,

Vinay Cv²

Abstract: This review is concerning Fast dissolving tablets ready by Novel Hole technology. Once these Fast dissolving tablets contact with gastric fluids, the fluid can enters the hole formed within the tablet and immediate breaking of the tablet goes to takes place. This quick disintegration of tablets is additionally influenced by the formation of latest absolute space. This method is novel and most helpful for formulation into Fast dissolving tablets.

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Cited by 2 publications

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Torsemide Fast Dissolving Tablets: Development, Optimization Using Box–Bhenken Design and Response Surface Methodology, In Vitro Characterization, and Pharmacokinetic Assessment

et al. 2017

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The present study planed to develop new fast dissolving tablets (FDTs) of torsemide. Solid dispersions (SDs) of torsemide and sorbitol (3:1) or polyvinylpyrrolidone (PVP) k25 were prepared. The prepared SDs were evaluated for in-vitro dissolution. Fourier transform infrared spectroscopy and differential scanning calorimetry for SDs revealed no drug/excipient interactions and transformation of torsemide to the amorphous form. Torsemide/sorbitol SD was selected for formulation of torsemide FDTs by direct compression method. Box-Bhenken factorial design was employed to design 15 formulations using croscarmellose sodium and crospovidone at different concentrations. The response surface methodology was used to analyze the effect of changing these concentrations (independent variables) on disintegration time (Y), percentage friability (Y), and amount torsemide released at 10 min. The physical mixtures of torsemide and the used excipients were evaluated for angle of repose, Hausner's ratio, and Carr's index. The prepared FDTs tablets were evaluated for wetting and disintegration time, weight variation, drug content, percentage friability, thickness, hardness, and in vitro release. Based on the in-vitro results and factorial design characterization, F10 and F7 were selected for bioavailability studies following administration to Albino New Zealand rabbits. They showed significantly higher C and (AUC) and shorter T than those obtained after administration of the corresponding ordinary commercial Torseretic ® tablets. Stability study was conducted for F10 that showed good stability upon storage at 30°C/75% RH and 40°C/75% RH for 3 months.

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Torsemide Fast Dissolving Tablets: Development, Optimization Using Box–Bhenken Design and Response Surface Methodology, In Vitro Characterization, and Pharmacokinetic Assessment

et al. 2017

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Fast Dissolving Tablets – a Novel Approach in Drug Delivery

Khan¹,

Tripuraneni²

2014

RGUHS J Pharm Sci.

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Role of Novel Hole Technology in Fast Dissolving Tablets

Cited by 2 publications

References 36 publications

Torsemide Fast Dissolving Tablets: Development, Optimization Using Box–Bhenken Design and Response Surface Methodology, In Vitro Characterization, and Pharmacokinetic Assessment

Torsemide Fast Dissolving Tablets: Development, Optimization Using Box–Bhenken Design and Response Surface Methodology, In Vitro Characterization, and Pharmacokinetic Assessment

Fast Dissolving Tablets – a Novel Approach in Drug Delivery

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