Role of nuclear progesterone receptor isoforms in uterine pathophysiology

Patel, Brijesh; Elguero, Sonia; Thakore, Suruchi; Dahoud, Wissam; Bedaiwy, Mohamed A.; Mesiano, Sam

doi:10.1093/humupd/dmu056

Cited by 288 publications

(265 citation statements)

References 295 publications

(284 reference statements)

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“…Progesterone affects the vaginal epithelium and cervical mucus, making it thick and impenetrable to sperm. Progesterone is anti-mitogenic in endometrial epithelial cells, and as such, mitigates the tropic effects of estrogen 16 .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2017

IJPSR

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ABSTRACT:There are some herbal contraceptives that have the property to avoid the embryo implantation. Trigonella foenum-graecum Linn. is used in folk medicine as alcoholic and aqueous preparations for prevention of pregnancy. Pregnane-progesterone is one of the important steroid has direct connection with contraceptive activity. Pregnane is a C 21 steroid and indirectly, a parent of progesterone. The present work was carried out to find out the responsible phytochemical for contraceptive activity. The objective of this study was to provide an alternative contraception and thus evaluate the pregnane progesterone. The present work was carried out in Trigonella foenum-graecum Linn. with the presence of compound "Pregnane" and its importance in contraceptive activity. The present study showed the presence of [5 Beta]-Pregnane-3,20,beta-diol, [4 alpha] 8-alpha-[4-methyl-3-oxa]oxa-4-ozabutane-1,4 diyl-diacetate with retention time 36.23, peak area 5.335% (C 28 H 43 NO 6 Mol wt-489). This pregnane was found first time in this plant. Pregnane progestin contraception is effective and well tolerated, thus providing an excellent contraceptive alternative to the currently used methods. Pregnane can be isolated from Trigonella foenum-graecum Linn. for the preparation of Depo-Provera as a contraceptive measure.

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Section: Discussionmentioning

confidence: 99%

Untitled

2017

IJPSR

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“…Its presence is only observed in appreciable amounts during the luteal phase as its source is the corpus luteum, and its primary role during this time period is in endometrial remodeling as well as endometrial angiogenesis in preparation for the arrival of an early embryo (Patel B, 2014). While this effect is critical for the maintenance of pregnancy, just as important is the inhibitory role that P4 has -along with estrogen and inhibin -on the pituitary gonadotropins follicle stimulating hormone (FSH) and luteinizing hormone (LH), respectively (Lesoon LA, 1992).…”

Section: The Progesterone Receptor -To Be or Not To Be: The Anti-inflmentioning

confidence: 99%

Untitled

2017

stem

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Full version of volume 1 of the Proceedings of the Interdisciplinary STEM Teaching and Learning Conference.This complete issue is available in Proceedings of the Interdisciplinary STEM Teaching and Learning Conference:https://digitalcommons.georgiasouthern.edu/stem_proceedings/vol1/iss1/1Editor's NoteIt was with great pleasure that I was able to organize and put together the inaugural volume of the Proceedings of the Interdisciplinary STEM Teaching and Learning Conference. The opportunity to read the different studies and converse with authors from all over the region was rewarding and makes me proud of the good work being done in interdisciplinary STEM education.The first volume of the Proceedings of the Interdisciplinary STEM Teaching and Learning Conference includes topics from special education, curricular integration, using primary resources, methods for using new technologies, and cellular testing. I was truly impressed with the scope of the work presented at the conference and articulated in these papers.I want to acknowledge the Institute for Interdisciplinary STEM at Georgia Southern University and our fellows and affiliates who graciously and quickly assisted with the review process. Thank you to Lisa Stueve for leading this year's conference and Marsha Pate, Kania Greer, and Robert Mayes for all their support along the way. (National Science Foundation, 2015). The underrepresentation is a problem because the nation's competitiveness depends on diverse individuals with STEM knowledge, skills, and abilities to drive innovation that will need to new products and economic growth (Businesshigher Education Forum/A Policy Brief, 2014; National Academies of Sciences, Engineering, and Medicine, 2016; National Science Board, 2016). The author discusses the importance of engaging students with disabilities in informal Science, Technology, Engineering, and Mathematics activities.Keywords: extracurricular, clubs, STEM, disabilities, social skills, soft skills, informal, self-efficacy, self-determination The Importance of Extracurricular Activities for Students with DisabilitiesAll students, including students with disabilities (SWD) who participated in after-school programs that offer a variety of experiences develop skills and self-confidence (Kleinert, Miracle and Sheppard-Jones, 2007). These social and emotional skills are difficult to achieve in the typical classroom setting (Snellman, Silva, Frederick & Putnam, 2015). Kleinert and colleagues (2007) pointed out the Individuals with Disabilities Education Act (IDEA) requires schools to provide access to extracurricular activities and recommended participation in after-school programs is included in students' Individual Education Programs (IEPs). After-school clubs can integrate needed work place (soft skills, i.e. collaboration) and social skills interventions with students who share similar interests in a natural, informal, learning environment. Students with disabilities develop social competence by experiencing friendships and gaining valuable...

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“…PR exists in two isoforms PRA and PRB, which are transcribed from two promoters on a single gene [15,16] . Although PRB functions as a transcriptional activator of Pg responsive genes, PRA may function as a transcriptional inhibitor [17,18] . Several studies have demonstrated that PR is upregulated in uterine leiomyomata, as compared with adjacent normal myometrium [19] at mRNA and protein levels.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Medical Management of leipmyomas-emphasis for different geographical regions

KocharKaur¹

2015

JGNB

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Leiomyomas are the common benign tumours of uterus. Surgery is the most common mode of treatment of symptomatic fibroids. With the advent of minimally invasive interventional procedures like uterine artery embolization (UAE), and focused ultrasound on MRI we got some lesser invasive techniques, although they have drawbacks regarding ovarian reserve etc for patients desiring fertility. Initially GnRH agonists like leuprolide acetate were the most effective medical agents introduced, but their drawback was bone density demineralization, hot flushes on long term use besides cost. Selective progesterone receptor modulators gradually got introduced with initial trials with mifepristone (RU486), followed by asoprisnil, ulipristalacetate. Since mifepristone had antiglucocorticoid and androgen receptor activity it was not approved by FDA for license, while four PEARL trials have got completed for UPA acetate 5&10mg regarding safety and efficacy and intermittent therapy with 5mg got FDA approval in Europe and Canada before surgery. Further trials indicated it may be the future drug of choice for patients desiring fertility for long term intermittent therapy and possibly avoiding surgery and its complications like adhesions, uterine scar and risk for rupture during pregnancy. However in countries where uripristal is not available still one is forced to use mifepristone. Detailed mechanism of all these drugs is discussed and a case report of a young unmarried girl with high BMI is reported where mifepristone intermittent was effective not only in relieving patients symptoms but effective in decreasing uterine and fibroid volume which highlights how in such young cases one can preserve future fertility without putting them at risk of surgery and sometimes myomectomy complications ending in hysterectomy.

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Role of nuclear progesterone receptor isoforms in uterine pathophysiology

Cited by 288 publications

References 295 publications

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Medical Management of leipmyomas-emphasis for different geographical regions

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