Role of Nuclear Sentinel Lymph Node Mapping Compared to New Alternative Imaging Methods

Cuccurullo, Vincenzo; Rapa, Marco; Catalfamo, Barbara; Cascini, Giuseppe Lucio

doi:10.3390/jpm13081219

Cited by 3 publications

(2 citation statements)

References 78 publications

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“…Although alternative advanced imaging techniques such as MRI and nuclear medicine procedures (PET and lymphoscintigraphy) are crucial for cancer staging and surgery, they are not currently the primary diagnostic methods [38,39]. MRI stands out for its safety during pregnancy, excellent spatial and contrast resolution, absence of ionizing radiation, and non-operator-dependent results [40].…”

Section: Discussionmentioning

confidence: 99%

Automated 3D Ultrasound as an Adjunct to Screening Mammography Programs in Dense Breast: Literature Review and Metanalysis

Gatta,

Somma,

Sardu

et al. 2023

JPM

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Purpose: The purpose of this meta-analysis is to investigate the effectiveness of supplementing screening mammography with three-dimensional automated breast ultrasonography (3D ABUS) in improving breast cancer detection rates in asymptomatic women with dense breasts. Materials and Methods: We conducted a thorough review of scientific publications comparing 3D ABUS and mammography. Articles for inclusion were sourced from peer-reviewed journal databases, namely MEDLINE (PubMed) and Scopus, based on an initial screening of their titles and abstracts. To ensure a sufficient sample size for meaningful analysis, only studies evaluating a minimum of 20 patients were retained. Eligibility for evaluation was further limited to articles written in English. Additionally, selected studies were required to have participants aged 18 or above at the time of the study. We analyzed 25 studies published between 2000 and 2021, which included a total of 31,549 women with dense breasts. Among these women, 229 underwent mammography alone, while 347 underwent mammography in combination with 3D ABUS. The average age of the women was 50.86 years (±10 years standard deviation), with a range of 40–56 years. In our efforts to address and reduce bias, we applied a range of statistical analyses. These included assessing study variation through heterogeneity assessment, accounting for potential study variability using a random-effects model, exploring sources of bias via meta-regression analysis, and checking for publication bias through funnel plots and the Egger test. These methods ensured the reliability of our study findings. Results: According to the 25 studies included in this metanalysis, out of the total number of women, 27,495 were diagnosed with breast cancer. Of these, 211 were diagnosed through mammography alone, while an additional 329 women were diagnosed through the combination of full-field digital mammography (FFDSM) and 3D ABUS. This represents an increase of 51.5%. The rate of cancers detected per 1000 women screened was 23.25‰ (95% confidence interval [CI]: 21.20, 25.60; p < 0.001) with mammography alone. In contrast, the addition of 3D ABUS to mammography increased the number of tumors detected to 20.95‰ (95% confidence interval [CI]: 18.50, 23; p < 0.001) per 1000 women screened. Discussion: Even though variability in study results, lack of long-term outcomes, and selection bias may be present, this systematic review and meta-analysis confirms that supplementing mammography with 3D ABUS increases the accuracy of breast cancer detection in women with ACR3 to ACR4 breasts. Our findings suggest that the combination of mammography and 3D ABUS should be considered for screening women with dense breasts. Conclusions: Our research confirms that adding 3D automated breast ultrasound to mammography-only screening in patients with dense breasts (ACR3 and ACR4) significantly (p < 0.05) increases the cancer detection rate.

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Section: Discussionmentioning

confidence: 99%

Automated 3D Ultrasound as an Adjunct to Screening Mammography Programs in Dense Breast: Literature Review and Metanalysis

Gatta,

Somma,

Sardu

et al. 2023

JPM

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“…In recent years, new techniques of the study of the lymphatic system have been emerging with particular interest in sentinel lymph node mapping [6] and lymphedema diagnosis. The main features of the development process are the increase in spatial resolution, dose reduction and cost-efficacy.…”

Section: Introductionmentioning

confidence: 99%

The Role of Imaging of Lymphatic System to Prevent Cancer Related Lymphedema

Cuccurullo,

Rapa,

Catalfamo

et al. 2023

Bioengineering

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Lymphedema is a progressive chronic condition affecting approximately 250 million people worldwide, a number that is currently underestimated. In Western countries, the most common form of lymphedema of the extremities is cancer-related and less radical surgical intervention is the main option to prevent it. Standardized protocols in the areas of diagnosis, staging and treatment are strongly required to address this issue. The aim of this study is to review the main diagnostic methods, comparing new emerging procedures to lymphoscintigraphy, considered as the golden standard to date. The roles of Magnetic Resonance Lymphangiography (MRL) or indocyanine green ICG lymphography are particularly reviewed in order to evaluate diagnostic accuracy, potential associations with lymphoscintigraphy, and future directions guided by AI protocols. The use of imaging to treat lymphedema has benefited from new techniques in the area of lymphatic vessels anatomy; these perspectives have become of value in many clinical scenarios to prevent cancer-related lymphedema.

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Setting-up a training programme for intraoperative molecular imaging and sentinel node mapping: how to teach? How to learn?

Valdés Olmos,

Collarino,

Rietbergen

et al. 2023

Eur J Nucl Med Mol Imaging

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Role of Nuclear Sentinel Lymph Node Mapping Compared to New Alternative Imaging Methods

Cited by 3 publications

References 78 publications

Automated 3D Ultrasound as an Adjunct to Screening Mammography Programs in Dense Breast: Literature Review and Metanalysis

Automated 3D Ultrasound as an Adjunct to Screening Mammography Programs in Dense Breast: Literature Review and Metanalysis

The Role of Imaging of Lymphatic System to Prevent Cancer Related Lymphedema

Setting-up a training programme for intraoperative molecular imaging and sentinel node mapping: how to teach? How to learn?

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