Role of nucleocytoplasmic transport in interphase microtubule organization in fission yeast

TACC3 Regulates Microtubule Plus-End Dynamics and Cargo Transport in Interphase Cells

“…By recruiting chTOG, TACC3 functions at the centrosome to regulate MT nucleation, along the MT lattice to stabilize the spindle apparatus, and at the MT plus-end to promote mitotic spindle elongation (Gergely et al, 2000(Gergely et al, , 2003Kinoshita et al, 2005;Lee et al, 2001;Lin et al, 2010;Mortuza et al, 2014). However, our understanding of the potential functions of TACC3 in interphase remains limited (Chanez et al, 2015;Gunzelmann et al, 2018;Kume et al, 2018;Nakamura et al, 2012;Nakaseko et al, 2001;Trogden and Rogers, 2015). In yeast, the homolog of TACC3, Alp7, recruits Alp14/TOG to the nucleus during cell division or to the cytoplasm during interphase.…”