Role of nucleosides and nucleotides in the immune system, gut reparation after injury, and brain function

Nutritional and technological aspects of minor bioactive components in milk and whey: Growth factors, vitamins and nucleotides

“…Furthermore, dietary nucleotides influence biosynthetic processes and modulate gene expression, at least of those genes involved in nucleotide metabolism (Sanchez-Pozo & Gil, 2002). According to Yamamoto, Wang, Adjei, and Ameho (1997) supplementation with nucleosides and nucleotides is beneficial to the functions of the system and the brain, but effects to the gut appear to depend on the type of damage. Finally, Grimble and Westwood (2001) propose that the effect of dietary nucleotides is exerted at the mucosal barrier, specifically through a sensing mechanism (currently unknown) which involves purinergic signalling.…”

Exogenous nucleosides modulate expression and activity of transcription factors in Caco-2 cells

“…Moreover, intestinal homeostasis may depend on exogenous supplies of NTs because the de novo NT synthesis seems to be limited. Therefore, NTs can be considered as "semi-essential" nutrients, especially during periods of starvation, injury or stress [12][13][14][15][16].…”

Nucleotides in broiler chicken diet: effect on breast muscles quality

“…Although many studies have focussed the attention on the effects of nucleotides supplementation as one of the most important aspects of research in clinical nutrition and functional food development for humans (Sanchez-Pozo & Gil 2002) thanks to their capacity to induce intestinal anabolic effects expressed by increased mucosal protein, DNA, villous height, and brush-order enzyme activities (Uauy et al 1990), there is little information on animal nutrition even though, the researches pertaining to nucleotide administration in rats (Yamamoto et al 1997), piglets (Domeneghini et al 2004;Martinez-Puig et al 2007), and broiler chickens Riolo et al 2006;Esteve-Garcia et al 2007) have shown rather consistent and encouraging beneficial results in the health management thanks to their potential effects as growth promoters.…”