Role of nutraceuticals in cognition during aging and related disorders

Singh, Padmanabh; Sivanandam, Thamil Mani; Konar, Arpita; Thakur, M. K.

doi:10.1016/j.neuint.2020.104928

Cited by 23 publications

(19 citation statements)

References 177 publications

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“…Recent knowledge about the versatile behavior of these nutraceuticals have increased their commercial demand and expanded their market requirement. 30 Besides their commercial importance, their presence, along with other toxic chemicals in their respective sources, make them unable to be consumed directly. 31 Furthermore, a low concentration of certain nutraceuticals makes them highly impossible to be ingested by direct human consumption.…”

Section: ■ Introductionmentioning

confidence: 99%

Sustainable and Green Engineering Insights on Deep Eutectic Solvents toward the Extraction of Nutraceuticals

Balaraman

Rangabhashiyam

Rangarajan

et al. 2021

ACS Sustainable Chem. Eng.

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Deep eutectic solvents (DES) hold promising potential in the selective purification of bioactive molecules from various complex sources. Although they are increasingly considered as a biocompatible extraction medium, adding the task-specific functionality, which makes DES distinctive for the selective extraction of compounds, requires appropriate tailoring of their physical properties. This critical review investigates the influential physical properties of deep eutectic solvents and their effect on various sustainable extraction methodsincluding both solid–liquid and liquid–liquidfor the separation of nutraceuticals. Various methods by which DES are employed as solvents, cosolvents, or as adjuvants in different extraction systems are compared in terms of their efficiency and selectivity. Furthermore, the correspondence between the type of DES and the nature of target nutraceuticals to be extracted is also discussed. The Review highlights the key achievements and future prospects of employing DES along with the lacunae in the current investigations and proposed various approaches for sustainable applications.

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Section: ■ Introductionmentioning

confidence: 99%

Sustainable and Green Engineering Insights on Deep Eutectic Solvents toward the Extraction of Nutraceuticals

Balaraman

Rangabhashiyam

Rangarajan

et al. 2021

ACS Sustainable Chem. Eng.

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“…Natural or dietary tannins are nutraceutical factors that have been reported in cognitive impairment amelioration [ 127 , 128 ]. Furthermore, dose-dependent cell-line neuroprotective activity has been reported in natural gallotannins and ellagitannins against H 2 O 2 -based oxidative damage, using the hybridoma cell line NG108–15 [ 129 ].…”

Section: Neuroprotective Mechanistic Narratives Of Active Principles ...mentioning

confidence: 99%

Suitability of Banana and Plantain Fruits in Modulating Neurodegenerative Diseases: Implicating the In Vitro and In Vivo Evidence from Neuroactive Narratives of Constituent Biomolecules

Oyeyinka

Afolayan

2022

Foods

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Active principles in plant-based foods, especially staple fruits, such as bananas and plantains, possess inter-related anti-inflammatory, anti-apoptotic, antioxidative, and neuromodulatory activities. Neurodegenerative diseases affect the functionality of the central and peripheral nervous system, with attendant cognitive deficits being hallmarks of these conditions. The dietary constitution of a wide range of bioactive compounds identified in this review further iterates the significance of the banana and plantain in compromising, halting, or preventing the pathological mechanisms of neurological disorders. The neuroprotective mechanisms of these biomolecules have been identified by using protein expression regulation and specific gene/pathway targeting, such as the nuclear and tumor necrosis factors, extracellular signal-regulated and mitogen-activated protein kinases, activator protein-1, and the glial fibrillary acidic protein. This review establishes the potential double-edged neuro-pharmacological fingerprints of banana and plantain fruits in their traditionally consumed pulp and less utilized peel component for human nutrition.

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“…Due to their antioxidant properties, these compounds efficiently scavenge or neutralize oxidative free radicals and thereby improve or recover underlying conditions ( Fraga et al, 2019 ). Both animal models and clinical trial studies showed that these plant-derived bioactive compounds are neuroprotective and improve cognitive decline associated with aging and neurodegenerative diseases by reducing oxidative stress, mitochondrial dysfunction, and oxidative stress-mediated neurodegeneration ( Singh et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress-mediated memory impairment during aging and its therapeutic intervention by natural bioactive compounds

Singh

Barman

Thakur

2022

Front. Aging Neurosci.

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Aging and associated neurodegenerative diseases are accompanied by the decline of several brain functions including cognitive abilities. Progressive deleterious changes at biochemical and physiological levels lead to the generation of oxidative stress, accumulation of protein aggregates, mitochondrial dysfunctions, loss of synaptic connections, and ultimately neurodegeneration and cognitive decline during aging. Oxidative stress that arises due to an imbalance between the rates of production and elimination of free radicles is the key factor for age-associated neurodegeneration and cognitive decline. Due to high energy demand, the brain is more susceptible to free radicals-mediated damages as they oxidize lipids, proteins, and nucleic acids, thereby causing an imbalance in the homeostasis of the aging brain. Animal, as well as human subject studies, showed that with almost no or few side effects, dietary interventions and plant-derived bioactive compounds could be beneficial to recovering the memory or delaying the onset of memory impairment. As the plant-derived bioactive compounds have antioxidative properties, several of them were used to recover the oxidative stress-mediated changes in the aging brain. In the present article, we review different aspects of oxidative stress-mediated cognitive change during aging and its therapeutic intervention by natural bioactive compounds.

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Role of nutraceuticals in cognition during aging and related disorders

Cited by 23 publications

References 177 publications

Sustainable and Green Engineering Insights on Deep Eutectic Solvents toward the Extraction of Nutraceuticals

Sustainable and Green Engineering Insights on Deep Eutectic Solvents toward the Extraction of Nutraceuticals

Suitability of Banana and Plantain Fruits in Modulating Neurodegenerative Diseases: Implicating the In Vitro and In Vivo Evidence from Neuroactive Narratives of Constituent Biomolecules

Oxidative stress-mediated memory impairment during aging and its therapeutic intervention by natural bioactive compounds

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