Role of obesity and blood pressure in epicardial adipose tissue thickness in children

Sánchez, Isabel María Blancas; Aristizábal-Duque, Cristhian H.; Cabeza, Juan Fernández; Aparicio-Martínez, Pilar; Álvarez, Manuel Vaquero; Ortiz, Martín Ruiz; Rubio, María Dolores Mesa; Pozo, Francisco Javier Fonseca del

doi:10.1038/s41390-022-02022-x

Cited by 2 publications

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References 42 publications

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“…Our group has previously reported that overweight and obesity are associated with adverse changes in cardiac morphology and function parameters. The study, performed using a conventional echocardiography, 21 reports a direct correlation between these alterations and higher epicardial adipose tissue thickness 22 in a rural population of Spanish children and adolescents. We have also described normal values of strain in several heart chambers in healthy children and adolescents using this novel software 23 …”

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confidence: 99%

The effects of obesity on longitudinal ventricular and atrial strain in a rural population of Spanish children and adolescents, evaluated by a new strain software

et al. 2023

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SummaryBackground and ObjectivesResearch on the relationship between body mass index (BMI) and strain values in children and adolescents is limited. Our aim was to analyse the relationship between BMI and strain values of both ventricles and left atrium in children and adolescents.MethodsBoth ventricles and left atrial strain values were compared among different BMI categories in children and adolescents from a town in the South of Spain.ResultsOf the 198 subjects, aged 6–17 years, 53% were of normal weight, 26% were overweight and 21% had obesity. Lower absolute values of left ventricular global longitudinal strain (25.9 ± 2.0% vs. 26.9 ± 2.2%, p = 0.002) and right ventricular free wall longitudinal strain (29.5 ± 4.2% vs. 30.8 ± 4.5%, p = 0.04) were found in subjects with obesity and overweight versus subjects with normal weight. A lower right ventricular four‐chamber longitudinal strain was also observed in males with obesity and overweight (24.8 ± 3.3% vs. 26.4 ± 3.6%, p = 0.03). Statistically significant negative correlations of BMI were found for all ventricular, but not atrial, strain values in univariate analysis. This association turned non‐significant for right ventricular four‐chamber longitudinal strain in multivariate analysis.ConclusionsUtilizing this new strain software, children and adolescents with high BMI were associated with significantly lower values for left and right ventricular free wall longitudinal strain, without impact in left atrial strain.

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Section: Introductionmentioning

confidence: 99%

The effects of obesity on longitudinal ventricular and atrial strain in a rural population of Spanish children and adolescents, evaluated by a new strain software

et al. 2023

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Evaluation of metabolic syndrome components, serum uric acid levels and epicardial adipose tissue thickness in pubertal children by severity of obesity

Büyükyılmaz,

Özdemir Şahan

2024

Turk J Pediatr

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Background. We aimed to evaluate how the parameters used in the diagnosis of metabolic syndrome (MetS) and parameters such as epicardial adipose tissue (EAT) thickness, insulin resistance (IR), and serum uric acid (SUA) are affected according to the severity of obesity. Methods. A total of 120 obese patients aged 10-18 years were classified as class 1-2-3 according to their body mass index (BMI) score. SUA was measured and oral glucose tolerance tests were performed on all patients. MetS components were determined according to the International Diabetes Federation 2007 criteria. IR was calculated using homeostatic model assessment for insulin resistance (HOMA-IR) and whole body insulin sensitivity index (WBISI). Results. HOMA-IR was higher in the class 3 group than in the class 1 (p<0.001) and class 2 groups (p<0.01). WBISI was lower in the class 3 group than in the class 1 (p=0.015) and class 2 groups (p<0.01). EAT thickness was higher in the class 3 group than in the class 1 (p<0.01) and class 2 groups (p<0.01). No significant difference was found between class 1 and 2 groups for HOMA-IR, WBISI, and EAT thickness variables. The frequency of the MetS components was similar between the class of obesity groups (p=0.702). SUA and EAT thickness were significantly higher in the group with 2 and/or more MetS components than in the group with no MetS component. EAT thickness was positively and moderately correlated with SUA levels (Rho=0.319, p<0.001). Conclusions. A more significant increase in cardiovascular disease risk factors, especially after class 2 obesity suggests that obese people should be followed closely and necessary interventions made for the prevention and progression of obesity. SUA and EAT thickness, an important risk factor affecting the obesity-related comorbidities, are positively correlated with each other and can be used in the follow-up of obese children.

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Role of obesity and blood pressure in epicardial adipose tissue thickness in children

Cited by 2 publications

References 42 publications

The effects of obesity on longitudinal ventricular and atrial strain in a rural population of Spanish children and adolescents, evaluated by a new strain software

The effects of obesity on longitudinal ventricular and atrial strain in a rural population of Spanish children and adolescents, evaluated by a new strain software

Evaluation of metabolic syndrome components, serum uric acid levels and epicardial adipose tissue thickness in pubertal children by severity of obesity

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