Role of OMEGA-3 Fatty Acid Supplementation in COVID-19 Patients: A Narrative Review

Akram, Zoia; Allenki, Alekhya; Kishore, S. Ravindra; Ogwu, Dolly; Adefalu, Olufunlola Titilayo; Villatoro, Antonia Lisseth Valle; Omole, Janet A; Uddin, Giass; Gopal, Shwetha; Khan, Abdurrahman Mir; Lodi, Maham Nuzhat; Shahbaz, Tarab; Nabeel, Noor Ul Huda; Vega, Lisandra; Tariq, Usman; Nkongho, Mireille B

doi:10.26502/aimr.0069

Cited by 2 publications

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“…According to new findings, the SARS-CoV-2 spike (S) glycoprotein of SARS-CoV-2 interacts with angiotensin-converting enzyme-2 (ACE2) and cellular protease transmembrane protease serine-2 (TMPRSS-2) as internalization receptors to enter host cells during the infection cycle. Downregulation of ACE2 by SARS-CoV-2 causes a reduction in ACE2 products such as Ang- [1] , [2] , [3] , [4] , [5] , [6] , [7] , Ang [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , apelin [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , and accumulation of substrates such as apelin [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] and Ang II [82] . ACE2 downregulation correlates with systemic RAS imbalance and facilitates the development of multiorgan damage from SARS-CoV-2 infections [83] .…”

Section: Discussionmentioning

confidence: 99%

“…Covid-19 is an acute respiratory syndrome disease caused by SARS-COV-2, which was introduced as a pandemic in early 2020 and has been diagnosed in more than 230 million people worldwide by September 2021 [1] , [2] . The disease worsens with age (especially over 60 years), male sex, and underlying diseases and its mortality is largely associated with rapidly increasing inflammatory cytokines, including interleukin-6 (IL-6) [3] .…”

Section: Introductionmentioning

confidence: 99%

“…PUFAs include omega-3 PUFA and omega-6 PUFA which the former acids originate from natural sources and include alpha linoleic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) [2] , [3] and the latter one, mainly contain linoleic acid (LA) and arachidonic acid (AA) [10] .…”

Section: Introductionmentioning

confidence: 99%

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The effect of polyunsaturated fatty acids on the severity and mortality of COVID patients: A systematic review

Mazidimoradi

Alemzadeh

et al. 2022

Life Sciences

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effect of polyunsaturated fatty acids on the severity and mortality of COVID patients: A systematic review

Mazidimoradi

Alemzadeh

et al. 2022

Life Sciences

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“…Supplementing omega-3 FAs to COVID-19 patients may help to reduce inflammation. Omega 3 FAs are able to play an important role to prevent cytokine storm by reducing the severity of inflammation and thus are able to decline the risk of mortality in patients infected with COVID-19 (Akram et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Omega 3 Fatty Acids’ Effects on COVID-19

Şengül

UFUK

2022

Ataturk University Journal of Agricultural Faculty

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Recently, the novel coronavirus, which is called severe acute respiratory syndrome coronavirus 2, has been responsible for the highly rapid spread of COVID-19 disease, globally. Until now, 535 million people were affected and 6.3 million people died due to this outbreak throughout the World. Although the lethality of this disease is lower than the severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome, severe complications of this disease are attributed to "cytokine storm" that is the reason for the severe lung damage. The cytokine storm causes systemic inflammation, acute respiratory distress syndrome, septic shock, stroke, multiple organ dysfunction, and death. As a result of these symptoms, there are pivotal studies about vaccination, drug, and medication to prevent severe complications and treat patients with COVID-19. Besides these studies, some research shows that nutrients are able to manage the cytokine storm such as many types of vitamins, trace elements, and omega 3 fatty acids. Omega 3 polyunsaturated fatty acids have specific roles in the inflammatory process. Omega 3 fatty acids have a role in the improvement of the inflammatory balance. They interact with viral infection in disparate stages such as viral entry and replication. This study highlights the roles of omega 3 polyunsaturated fatty acids in the prevention and treatment of the COVID-19. In addition, omega 3 fatty acids show anti-viral and anti-inflammatory effects on the severe acute respiratory syndrome coronavirus 2 and increase survival rates in patients infected with COVID-19.

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Role of OMEGA-3 Fatty Acid Supplementation in COVID-19 Patients: A Narrative Review

Cited by 2 publications

References 0 publications

The effect of polyunsaturated fatty acids on the severity and mortality of COVID patients: A systematic review

The effect of polyunsaturated fatty acids on the severity and mortality of COVID patients: A systematic review

Omega 3 Fatty Acids’ Effects on COVID-19

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