Role of omega-3 fatty acids in the prevention and treatment of cardiovascular Diseases: A consensus statement from the Experts’ Committee Of National Society Of Cardiometabolic Medicine

Li, Jianjun; Dou, Kefei; Zhou, Zhiguang; Zhao, Dong; Zhao, Jiajun; Guo, Lixin

doi:10.3389/fphar.2022.1069992

Cited by 12 publications

(7 citation statements)

References 119 publications

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“…Fish oil, with a selected composition (e.g. ω-3 ω-6), has been used for more than a decade to counteract lipid deposits, with specific reference to LDL (low density lipoprotein) cholesterol or to HDL (high density lipoprotein) on LDL cholesterol ratio (HDL/LDL), thus to prevent cardiovascular diseases ( 51 , 52 ). Here these components, added to the vitamins and selenomethionine, may further support the whole lipid metabolism to diminish the well-known inflammatory detrimental status strictly linked to the fat deposit in overweight subjects.…”

Section: Discussionmentioning

confidence: 99%

Antioxidants positively regulate obesity dependent circRNAs - sperm quality - functional axis

Mele,

Chioccarelli,

Finamore

et al. 2023

Front. Endocrinol.

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Obesity is a pathophysiological condition, dependent on body fat accumulation, that progressively induces systemic oxidative stress/inflammation leading to a set of associated clinical manifestations, including male infertility. CircRNAs, covalently closed RNA molecules, are key regulators of sperm quality. Recently, we have characterized a complete profile of high-fat diet (HFD) spermatic circRNA cargo, predicting paternal circRNA dependent networks (ceRNETs), potentially involved in sperm oxidative stress and motility anomalies. In the current work, using HFD C57BL6/J male mice, orally treated with a mix of bioactive molecules (vitamin C; vitamin B12; vitamin E; selenium-L-methionine; glutathione-GSH) for 4 weeks, a reversion of HFD phenotype was observed. In addition, the functional action of the proposed formulations on circRNA biogenesis was evaluated by assessing the endogenous spermatic FUS-dependent backsplicing machinery and related circRNA cargo. After that, spermatic viability and motility were also analyzed. Paternal ceRNETs, potentially involved in oxidative stress regulation and sperm motility defects, were identified and used to suggest that the beneficial action of the food supplements here conveniently formulated on sperm motility was likely due to the recovery of circRNA profile. Such a hypothesis was, then, verified by an in vitro assay.

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Section: Discussionmentioning

confidence: 99%

Antioxidants positively regulate obesity dependent circRNAs - sperm quality - functional axis

Mele,

Chioccarelli,

Finamore

et al. 2023

Front. Endocrinol.

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“…Moreover, a statistically significant decrease in low-grade inflammation biomarkers levels, such as Tumor Necrosis Factor-alpha (TNF-alpha) or Interleukin-6 (IL-6), was also observed [48]. However, recent studies suggest that the proper validation of dosage and composition of DHA and EPA are needed to assess more deeply the role of n-3 PUFAs in atherosclerotic cardiovascular disease risk reduction, due to the inconsistent results of large randomized clinical trials [49,50].…”

Section: Role Of N-3 Pufas In the Acute Phase Of The Bipolar Disorder...mentioning

confidence: 99%

The role of Omega-3 Polyunsaturated Fatty Acids in the treatment of Bipolar Disorder – a narrative review

Rogalski,

Pokrywka,

Tomczak

2024

Med Srod.

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Introduction and Objective. Bipolar Disorder (BD) is a chronic mental condition associated with significant impairment of psychosocial functioning and premature mortality due to somatic comorbidities, as well as high rates of completed suicides. Unfortunately, results of currently available methods of treatment are unsatisfactory. Thus, new therapeutic solutions are sought. Recently, particular attention has been paid to the use of nutraceuticals, especially Omega-3 Polyunsaturated Fatty Acids (n-3 PUFAs), as an adjunctive treatment in various mental disorders. The aim of the review is to show the role of PUFAs in the pathogenesis of BD, and present results of already conducted studies investigating n-3 PUFAs supplementation effects on the BD clinical course. Materials and Method. Internet scientific bases were searched throughout January and February 2024 for the relevant to this topic literature from the past 15 years, using keywords: "bipolar disorder", "cardiovascular risk", "mental disorders", "omega-3 fatty acids", "polyunsaturated fatty acids", "remission", "treatment". Original and review articles were included. Manuscripts in other language than English were excluded from the search. To assess the proper quality of this manuscript, the Scale for the Assessment of Narrative Review Articles were used. Brief description of the state of knowledge. There is lack of research assessing the importance of n-3 PUFAs in the treatment of BD. However, it seems that their supplementation may bring significant benefits in the acute phase of depression episode treatment, remission maintenance and reduction in cardiometabolic risk factors. Summary. Results of already conducted studies should be treated as a rationale for future research. It is highly recommended to confirm the n-3 PUFAs efficiency in the BD treatment, to justify their widespread use in everyday clinical practice.

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“…3 . Fish consumption helps to prevent heart disease, stroke, and other cardiovascular diseases due to its omega-3 fatty acids [ 15 ]. Consuming fish twice a week can lower the risk of heart disease and stroke due to its high content of omega-3 fatty acids [ 16 ].…”

Section: Health Benefits Of Fish Consumptionmentioning

confidence: 99%

Health benefits and health risks of contaminated fish consumption: Current research outputs, research approaches, and perspectives

Demelash Abera,

Alefe Adimas

2024

Heliyon

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Role of omega-3 fatty acids in the prevention and treatment of cardiovascular Diseases: A consensus statement from the Experts’ Committee Of National Society Of Cardiometabolic Medicine

Cited by 12 publications

References 119 publications

Antioxidants positively regulate obesity dependent circRNAs - sperm quality - functional axis

Antioxidants positively regulate obesity dependent circRNAs - sperm quality - functional axis

The role of Omega-3 Polyunsaturated Fatty Acids in the treatment of Bipolar Disorder – a narrative review

Health benefits and health risks of contaminated fish consumption: Current research outputs, research approaches, and perspectives

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