Role of opsins and light or heat activated transient receptor potential ion channels in the mechanisms of photobiomodulation and infrared therapy

Sharma, Sunil; Sardana, Sakshi; Hamblin, Michael R.

doi:10.1016/j.jpap.2023.100160

Cited by 17 publications

(8 citation statements)

References 75 publications

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“…LLLT, also known as photobiomodulation (PBM), uses low levels of red or IR light to stimulate cellular function and treat various conditions like pain, inflammation, wound healing and brain disorders. [30][31][32][33] While the mechanism of near-infrared (NIR) PBM is complex and not yet fully understood, several hypotheses have been proposed to explain its effects. One hypothesis is based on the enhancement of enzymatic activities.…”

Section: Discussionmentioning

confidence: 99%

Illuminating a bacterial adaptation mechanism: Infrared-driven cell division in deep-sea hydrothermal vent environments

Dai,

Li,

Zhang

et al. 2024

TIG

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<p>Based on Planck's black-body radiation law, deep-sea hydrothermal vent chimneys emit light, predominantly infrared light, which potentially support bacterial photosynthesis in this ecosystem independently of the solar energy. To investigate the impact of this geothermal light on bacterial growth, we collected samples from the Southwest Indian Ridge and demonstrated that infrared light alone promotes bacterial growth and alters population composition. The mechanism of infrared stimulated growth was analyzed by monitoring cell wall synthesis using the <i>Tepidibacter hydrothermalis</i> strain SWIR-1, which was isolated from cultures enriched through infrared irradiation. The results showed that the elevated hydrostatic pressure inhibited septal peptidoglycan synthesis and cell division, but had less effect on cell elongation, chromosome replication and segregation. The dominant cell shape was filaments with some swelling and inertness in cell wall synthesis depending on the level of pressure applied. Interestingly, irradiation with 880 nm infrared light effectively initiated septal synthesis and alleviated the obstruction. This revelation uncovers a novel adaptation mechanism involving infrared light for bacteria dwelling in deep-sea environments, and sheds light on the potential of infrared-mediated photobiomodulation.</p>

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Section: Discussionmentioning

confidence: 99%

Illuminating a bacterial adaptation mechanism: Infrared-driven cell division in deep-sea hydrothermal vent environments

Dai,

Li,

Zhang

et al. 2024

TIG

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“…Lower energy doses may selectively activate specific pathways involved in odontogenic differentiation, leading to a more focused and efficient cellular response. Higher energy doses, on the other hand, may activate additional or different pathways that could interfere with or dampen the desired odontogenic differentiation [65,66].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Effects of Low-Level Laser Therapy on the Cytocompatibility and Osteo/Odontogenic Potential of Gingival-Derived Mesenchymal Stem Cells: Preliminary Report

et al. 2023

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Numerous tissue engineering uses for gingival-derived mesenchymal stem cells (GMSCs) have been demonstrated. Recently, low-level laser therapy (LLLT) has been projected as a factor that can improve MSCs’ regeneration capacity. Therefore, the aim of this research was to examine the impact of LLLT at 1.5 J/cm2 and 3 J/cm2 on the viability and osteo/odontogenic potential of GMSCs. An MTT assay was performed to detect viability. Osteo/odontogenic differentiation was evaluated using Alizarin Red S staining and qRT-PCR for the evaluation of the RUNX2, OC, DMP1, and DSPP genes. A two-way ANOVA with Tukey’s post hoc test was used to determine the statistical significance between groups. The results revealed that LLLT of both energy densities had no cytotoxic effect on GMSC viability. LLLT of 1.5 J/cm2 demonstrated better viability than the higher energy density (3 J/cm2). Furthermore, the osteo/odontogenic differentiation potential was promoted following LLLT radiation, where both groups exhibited mineralized nodule formation, with the low-energy laser having a significantly higher Alizarin Red S stain level. A qRT-PCR analysis revealed higher expression levels of osteogenic and odontogenic markers in the LLLT groups compared to the control group. In conclusion, this study showed the potential application of LLLT as a non-toxic and effective strategy to enhance the regenerative capacity of GMSCs for tissue engineering and clinical treatments in the oral and craniofacial fields.

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“…Moreover, the BDNF reduction in PSD-S can result in apoptosis and poor cognitive ability [ 20 ]. PBM ability involves NIR absorption through chromophore compounds like cytochrome and transient receptor protein family (TRP) [ 32 ], which are activated by various stimuli and have versatile cellular roles [ 82 ]. TRPC mediates BDNF, sustaining membrane depolarization and increasing dendritic spine density [ 83 ].…”

Section: Discussionmentioning

confidence: 99%

Transcranial Irradiation Mitigates Paradoxical Sleep Deprivation Effect in an Age-Dependent Manner: Role of BDNF and GLP-1

Lutfy,

Essawy,

Mohammed

et al. 2023

Neurochem Res

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The growing prevalence of aged sleep-deprived nations is turning into a pandemic state. Acute sleep deprivation (SD) accompanies aging, changing the hippocampal cellular pattern, neurogenesis pathway expression, and aggravating cognitive deterioration. The present study investigated the ability of Near Infra Red (NIR) light laser to ameliorate cognitive impairment induced by SD in young and senile rats. Wistar rats ≤ 2 months (young) and ≥ 14 months (senile) were sleep-deprived for 72 h with or without transcranial administration of NIR laser of 830 nm. Our results showed that NIR photobiomodulation (PBM) attenuated cognitive deterioration made by SD in young, but not senile rats, while both sleep-deprived young and senile rats exhibited decreased anxiety (mania)-like behavior in response to PBM. NIR PBM had an inhibitory effect on AChE, enhanced the production of ACh, attenuated ROS, and regulated cell apoptosis factors such as Bax and Bcl-2. NIR increased mRNA expression of BDNF and GLP-1 in senile rats, thus facilitating neuronal survival and differentiation. The present findings also revealed that age exerts an additive factor to the cellular assaults produced by SD where hippocampal damages made in 2-month rats were less severe than those of the aged one. In conclusion, NIR PBM seems to promote cellular longevity of senile hippocampal cells by combating ROS, elevating neurotrophic factors, thus improving cognitive performance. The present findings provide NIR as a possible candidate for hippocampal neuronal insults accompanying aging and SD.

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Role of opsins and light or heat activated transient receptor potential ion channels in the mechanisms of photobiomodulation and infrared therapy

Cited by 17 publications

References 75 publications

Illuminating a bacterial adaptation mechanism: Infrared-driven cell division in deep-sea hydrothermal vent environments

Illuminating a bacterial adaptation mechanism: Infrared-driven cell division in deep-sea hydrothermal vent environments

Exploring the Effects of Low-Level Laser Therapy on the Cytocompatibility and Osteo/Odontogenic Potential of Gingival-Derived Mesenchymal Stem Cells: Preliminary Report

Transcranial Irradiation Mitigates Paradoxical Sleep Deprivation Effect in an Age-Dependent Manner: Role of BDNF and GLP-1

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