Role of oral examination in newly diagnosed multiple myeloma patients: A safe and simple way to detect light chain amyloidosis

Abstract

The salient feature of this study is the high prevalence of oral manifestations among MM patients with amyloidosis. These results highlight the value of routine oral cavity examination and biopsy as a safe and simple method for detecting light chain amyloidosis.

Lingual amyloidosis associated to multiple myeloma: case report

“…Penner et al [10] have reported that about 15% of patients with MM develop amyloidosis. Leiba et al [5] have evaluated 212 patients diagnosed with MM and of these, 6% were diagnosed with light chain amyloidosis, and 54% showed lesions in the oral cavity with amyloid deposits. No studies were identified where the manifestation of OA led to a diagnosis for the underlying disease, in this case, MM.…”

“…Also, some patients may be asymptomatic, being diagnosed through laboratory findings such as anemia, kidney disease, and high levels of proteins [2]. About 12% to 15% of MM patients develop amyloidosis during the course of the disease, although up to 30% have subclinical amyloid deposits [5]. Amyloidosis manifests itself as extracellular and irreversible deposition of amorphous and fibrillar proteins, known as amyloid, in different organs and tissues [6].…”

“…There is no consensus on the most appropriate treatment for OA manifestations, however, the excision of the lesion can be an alternative, taking into account aspects such as the extent of the lesion and the presence of discomfort to perform routine activities. [5]. The surgical approach presents a probability of recurrences, therefore, regular follow-up is indicated [5].…”

“…[5]. The surgical approach presents a probability of recurrences, therefore, regular follow-up is indicated [5].…”