2015
DOI: 10.1517/17425255.2015.1069274
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Role of organic cation transporters in drug–drug interaction

Abstract: When performing in vitro testing for drug-drug interactions, it must be considered that one inhibitory drug may inhibit different transported drugs with different affinities. After positive in vitro testing for drug-drug interaction, clinical tests are obligatory.

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Cited by 83 publications
(78 citation statements)
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“…Extensive in silico and in vitro evidence suggests that rat Oct1, rat Oct2 and human OCT2 form homo-oligomers (Keller et al, 2011;Koepsell, 2015). Only transcript variant 1 encodes full-length and functional OCT1 protein (Hayer et al, 1999) and amino acid sequence of the isoform 1 was chosen as the reference one (uniport.org).…”
Section: Oct1 Protein and Slc22a1 Genementioning
confidence: 99%
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“…Extensive in silico and in vitro evidence suggests that rat Oct1, rat Oct2 and human OCT2 form homo-oligomers (Keller et al, 2011;Koepsell, 2015). Only transcript variant 1 encodes full-length and functional OCT1 protein (Hayer et al, 1999) and amino acid sequence of the isoform 1 was chosen as the reference one (uniport.org).…”
Section: Oct1 Protein and Slc22a1 Genementioning
confidence: 99%
“…In the small intestine, OCT1 is supposed to be involved in both absorption and secretion of organic cations, although the physiological role of secretion in small intestine is less obvious (Jonker & Schinkel, 2004;Koepsell, 2015). In contrast to rodents, human OCT1 might be involved in the reabsorption of ultra-filtrated cations in human kidney (Jonker & Schinkel, 2004).…”
Section: Function Of Oct1mentioning
confidence: 99%
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