Role of ovarian steroids in modulating mood in premenstrual syndrome

Schechter, Deborah E.; Strasser, T.; Endicott, Jean; Petkova, E; Nee, John

doi:10.1016/0006-3223(96)84437-4

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies do, however, suggest that levels of estradiol, progesterone, or neurosteroids (eg, pregnenolone sulfate) may be correlated with symptom severity in women with PMS. 134 , 140 , 141 (See references 142 and 143 for summaries of hormonal studies of P.M.S.) If PMS is not due to a deficiency or excess of reproductive steroids (or of any other hormone studied to date), do these steroids play any role at all in the precipitation of the syndrome?…”

Section: Reproductive Endocrine-related Mood Disordersmentioning

confidence: 99%

Gonadal steroids, brain, and behavior: role of context

Rubinow

Schmidt

2002

Dialogues in Clinical Neuroscience

View full text Add to dashboard Cite

The nature and extent of the impact of gender and reproductive function on mood has been the subject of speculation and controversy for centuries. Over the past 50 years, however, it has become increasingly clear that not only is the brain a major target of reproductive steroid hormones, but additionally, the steroid hormones, as neuroregulators, create a context thai influences a broad range of brain activities; ie, neural actions and resultant behaviors are markedly different in the presence and absence of gonadal steroids. In turn, the actions of gonadal steroids are themselves context-dependent. Thus, even where it can be demonstrated thai gonadal steroids trigger mood disorders, the triggers are normal levels of gonadal steroids (to be contrasted with the mood disturbances accompanying endocrinopathies), and the mood disorders appear only in a subset of susceptible individuals. The context specificity and differential susceptibility to affective dysregulation seen in women with reproductive endocrine-related mood disorders are undoubtedly important underlying characteristics of a wide range of psychiatric disorders in which the triggers have not yet been identified. Consequently, reproductive endocrine-related mood disorders offer unparalleled promise for the identification of those contextual variables that permit biological stimuli to differentially translate into depression in individuals at risk.

show abstract

Section: Reproductive Endocrine-related Mood Disordersmentioning

confidence: 99%