Role of oxidants and antioxidants in diabetic wound healing

Martins‐Green, Manuela; Saeed, Shayan

doi:10.1016/b978-0-12-816413-6.00002-2

Cited by 7 publications

(8 citation statements)

References 94 publications

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“…Oxidative stress in tissues is the result of the imbalance between the level of reactive oxygen species (ROS) and the ability of antioxidative mechanism to remove the ROS [ 54 , 55 ]. While low tissue ROS levels initiate, high levels hinder the normal process of tissue healing [ 56 , 57 ]. The tissue ROS level is high in diabetes due to decrease or/and increase in catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) production.…”

Section: Discussionmentioning

confidence: 99%

Zerumbone-Loaded Nanostructured Lipid Carrier Gel Enhances Wound Healing in Diabetic Rats

Albaayit

Abdullah

Noor

2022

BioMed Research International

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This study investigated the healing effects of topical application of zerumbone, a well-known anti-inflammatory compounds loaded on nanostructured lipid carrier gel (Carbopol 940) (ZER-NLCG) on excisional wounds in streptozotocin-induced diabetic rats. Diabetic rats with inflicted superficial skin wound were topically treated with ZER-NLCG, empty NLCG, and silver sulfadiazine cream (SSDC) once daily for 21 days. Wound tissue samples were analyzed for proinflammatory cytokines, namely, interleukin-6 (IL-6), interleukin-1 β (IL-1β), and tumor necrosis factor-α (TNF-α), hydroxyproline contents, catalase, superoxide dismutase activities, and lipid peroxidation level, and were subjected to histopathological analysis, respectively. Among the treated groups, ZER-NLCG was the most effective at decreasing proinflammatory cytokine level and inflammatory cell infiltration while increasing antioxidant enzyme activities, hydroxyproline content, and granulation of wound tissues of diabetic rats. ZER-NLCG is a potent formulation for the enhancement of wound healing in diabetic rats through its anti-inflammatory, antioxidant, and tissue repair activities.

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Section: Discussionmentioning

confidence: 99%

Zerumbone-Loaded Nanostructured Lipid Carrier Gel Enhances Wound Healing in Diabetic Rats

Albaayit

Abdullah

Noor

2022

BioMed Research International

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“…Results from the present study showed that the CMS and CMS@CuO hydrogels were able to kill eight species of Gram-positive and Gram-negative bacteria that are pathogenic to humans. When a wound is in the inflammatory phase, a large amount of ROS such as superoxide (O 2 ), peroxynitrite (ONOO − ), and hydroxyl radicals (OH) are generated that damage the body’s proteins and DNAs [ 6 ]. The use of antioxidant materials orally or topically can control ROS and prevent oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…The use of antioxidant materials orally or topically can control ROS and prevent oxidative stress. Once the level of the antioxidant molecules is inadequate to protect the cells and tissues from excessive oxidative stress, delay in wound healing is inevitable [ 6 , 12 ]. The CMS@CuO hydrogels investigated in the present study have antioxidant properties that are higher than 75%.…”

Section: Discussionmentioning

confidence: 99%

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Bioactive Carboxymethyl Starch-Based Hydrogels Decorated with CuO Nanoparticles: Antioxidant and Antimicrobial Properties and Accelerated Wound Healing In Vivo

Abdollahi

Zare‬

Salimi

et al. 2021

IJMS

117

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In this study, nanocomposite hydrogels composed of sodium carboxymethylated starch (CMS)-containing CuO nanoparticles (CMS@CuO) were synthesized and used as experimental wound healing materials. The hydrogels were fabricated by a solution-casting technique using citric acid as a crosslinking agent. They were characterized by Fourier-transform infrared spectroscopy (FTIR), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and thermogravimetric analysis (TGA) to evaluate their physicochemical properties. In addition, swelling, antibacterial activities, antioxidant activities, cytotoxicity, and in vivo wound healing were investigated to evaluate the wound healing potential of the CMS@CuO nanocomposite hydrogels. Growth inhibition of the Gram-positive and Gram-negative pathogens, antioxidant activity, and swelling were observed in the CMS@CuO nanocomposite hydrogels containing 2 wt.% and 4 wt.% CuO nanoparticles. The hydrogel containing 2 wt.% CuO nanoparticles displayed low toxicity to human fibroblasts and exhibited good biocompatibility. Wounds created in rats and treated with the CMS@2%CuO nanocomposite hydrogel healed within 13 days, whereas wounds were still present when treated for the same time-period with CMS only. The impact of antibacterial and antioxidant activities on accelerating wound healing could be ascribed to the antibacterial and antioxidant activities of the nanocomposite hydrogel. Incorporation of CuO nanoparticles in the hydrogel improved its antibacterial properties, antioxidant activity, and degree of swelling. The present nanocomposite hydrogel has the potential to be used clinically as a novel wound healing material.

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“…It is well known that high levels of oxidative stress (OS) are present in human chronic wounds [39,40]. Under this premise, a mouse model of chronic wounds was developed by Kim et al [41] in db/db −/− mice that mimics chronic wounds in humans by increasing the levels of ROS in the wound tissue [41][42][43].…”

Section: Murine Modelsmentioning

confidence: 99%

Assessing Animal Models to Study Impaired and Chronic Wounds

Saeed,

Martins-Green

2024

IJMS

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Impaired healing wounds do not proceed through the normal healing processes in a timely and orderly manner, and while they do eventually heal, their healing is not optimal. Chronic wounds, on the other hand, remain unhealed for weeks or months. In the US alone, chronic wounds impact ~8.5 million people and cost ~USD 28–90 billion per year, not accounting for the psychological and physical pain and emotional suffering that patients endure. These numbers are only expected to rise in the future as the elderly populations and the incidence of comorbidities such as diabetes, hypertension, and obesity increase. Over the last few decades, scientists have used a variety of approaches to treat chronic wounds, but unfortunately, to date, there is no effective treatment. Indeed, while there are thousands of drugs to combat cancer, there is only one single drug approved for the treatment of chronic wounds. This is in part because wound healing is a very complex process involving many phases that must occur sequentially and in a timely manner. Furthermore, models that fully mimic human chronic wounds have not been developed. In this review, we assess various models currently being used to study the biology of impaired healing and chronic non-healing wounds. Among them, this paper also highlights one model which shows significant promise; this model uses aged and obese db/db−/− mice and the chronic wounds that develop show characteristics of human chronic wounds that include increased oxidative stress, chronic inflammation, damaged microvasculature, abnormal collagen matrix deposition, a lack of re-epithelialization, and the spontaneous development of multi-bacterial biofilm. We also discuss how important it is that we continue to develop chronic wound models that more closely mimic those of humans and that can be used to test potential treatments to heal chronic wounds.

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Role of oxidants and antioxidants in diabetic wound healing

Cited by 7 publications

References 94 publications

Zerumbone-Loaded Nanostructured Lipid Carrier Gel Enhances Wound Healing in Diabetic Rats

Zerumbone-Loaded Nanostructured Lipid Carrier Gel Enhances Wound Healing in Diabetic Rats

Bioactive Carboxymethyl Starch-Based Hydrogels Decorated with CuO Nanoparticles: Antioxidant and Antimicrobial Properties and Accelerated Wound Healing In Vivo

Assessing Animal Models to Study Impaired and Chronic Wounds

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