Role of oxidative stress and altered thyroid hormones in unexplained infertility

Rehman, Rehana; Rajpar, Hiba Ismail; Ashraf, Muhammad Waqar; Iqbal, Najeeha Talat; Lalani, Salima; Alam, Faiza

doi:10.5455/jpma.21140

Cited by 4 publications

(4 citation statements)

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“…Subfertile women commonly suffer from physical and psychiatric stress, and the financial pressure to get pregnant. [14][15][16][17] Although the treatment strategies for unexplained infertility typically involve AIH and IVF, [18][19][20] unfortunately, less than one-tenth of couples could achieve a live birth following the AIH treatment. Most of these couples still required IVF to have live births.…”

Section: Discussionmentioning

confidence: 99%

Subfertile Chinese patients with diminished ovarian reserve: An analysis of pregnancy outcomes of ART cycles

et al. 2023

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Objective: To analyze the pregnancy outcomes of patients presenting with infertility solely due to diminished ovarian reserve (DOR) and treated by assisted reproductive technology (ART), including artificial insemination by husband (AIH) and in vitro fertilization (IVF). Methods: This was a retrospective study of subfertile patients due to DOR attending the Center for Reproductive Medicine in Guangzhou, China, between January 2010 and October 2015. Patients were assigned into either the AIH or IVF group. Within each group, these patients were further subgrouped based on their serum basal follicle-stimulating hormone (bFSH) level (10 ≤ bFSH ≤ 12IU/L and bFSH > 12IU/L) and age (20–30, 31–35, 36–40, and 41–45 years). The live birth rates were compared among these groups and subgroups. Results: A total of 1,003 patients with a median age of 38.91 (21–45) years were enrolled in the study. The live birth rate following AIH was 5.61% (25/446), which was significantly lower than that following IVF (25.13%; 140/557). In the subgroup analysis, the cumulative live birth rates in AIH group were significantly lower than those in the IVF groups (in the 10–12 IU/L bFSH subgroup, 13.74% vs. 41.13% (P<0.05) for patients aged ≤35 years, and 4.82% vs. 19.77% (P<0.05) for patients aged >35 years; in the >12 IU/L bFSH subgroup, 9.52% vs. 29.91% (P<0.05) for patients aged ≤35 years, and 5.71% vs. 20.55% (P<0.05) for patients aged >35 years). Longitudinal analysis showed that majority of live births, in AIH or IVF groups, were achieved in the first two cycles. Conclusions: In subfertile women with DOR, live birth rates following AIH were significantly lower than IVF, especially for the aged women. Considering the low efficacy of AIH and that majority of live births were achieved in the first two cycles, we suggest no more than two AIH treatment attempts for the aged women with DOR. doi: https://doi.org/10.12669/pjms.39.2.6226 How to cite this: Wang ZY, Huang SX, Yang JD, Li DP, Xu YW. Subfertile Chinese patients with diminished ovarian reserve: An analysis of pregnancy outcomes of ART cycles. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.6226 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

Subfertile Chinese patients with diminished ovarian reserve: An analysis of pregnancy outcomes of ART cycles

et al. 2023

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“…Under normal conditions, thyroid hormones in the thyroid tissue form an oxidative environment during the synthesis process, and the thyroid itself has a complete antioxidant oxidase system, such as TPO, glutathione peroxidase, thioredoxin, etc., which constitutes an antioxidant barrier to protect the thyroid from oxidative stress [9].If the thyroid gland is injured or the thyroid hormone level is disturbed, the level of free radicals will increase and the oxidation balance in the thyroid gland will be destroyed [10].Excessive free radicals can cause damage to thyroid structural cells, destroy genomic stability, and promote the occurrence and progression of thyroid cancer. In addition, thyroid hormone plays a metabolic regulatory function by in uencing mitochondrial activity, and because its function depends on reactive oxygen species, the thyroid is particularly vulnerable to oxidative damage [11].Superoxide dismutase (SOD) is the most powerful antioxidant and free radical scavenger to defend against oxidative attack in human body, and is considered to be the rst line of defense of the antioxidant system in human body [12].Nitric oxide, a free radical gas synthesized by nitric oxide synthase, is synergistically elevated due to oxidative stress [13].…”

Section: Discussionmentioning

confidence: 99%

Role of oxidative stress and IL-17 induced inflammatory cytokines in thyroid carcinoma with Hashimoto's thyroiditis

xing,

lu,

Liu

et al. 2023

Preprint

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Objective: To investigate the expression changes and mechanism of oxidative stress and IL-17 induced inflammatory factors in thyroid cancer with Hashimoto's thyroiditis. Method: 40 patients with thyroid cancer accompanied by Hashimoto's thyroiditis were selected as the PTC+HT group, 45 patients with simple thyroid cancer as the PTC group, 42 patients with simple Hashimoto's thyroiditis as the HT group, and 40 healthy individuals as the control group (NC). Evaluate the oxidative stress indicators NO, eNOS, superoxide dismutase (SOD), inflammatory indicators IL-17A, IL-1β and IL-6, thyroid hormones and their antibodies TPOAb and TGAb, as well as related biochemical indicators. Result: The inflammatory and oxidative stress indicators such as IL-17A were significantly increased in the PTC and HT groups compared to the control group, while the PTC+HT group further increased; There was a significant difference in thyroid hormone levels between the PTC+HT group and the HT group compared to the control group (P<0.05); TPOAb, TGAb and NO, eNOS, IL-17A, IL-1 β、IL-6 showed a significant positive correlation and a significant negative correlation with SOD (P<0.05); eNOS, SOD, and IL-17A are risk factors for these three different diseases. Conclusion: IL-17 and its induced inflammatory factors and oxidative stress are highly expressed in PTC+HT, and the synergistic effect between inflammation and oxidative stress leads to thyroid hormone levels and antibody abnormalities in PTC+HT patients. eNOS, SOD, and IL-17A can serve as effective indicators for predicting the occurrence and evaluating changes in PTC+HT disease, and also provide a theoretical basis for future treatment of PTC+HT.

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“…Полученные результаты подтверждаются исследованиями других ученых. Анализ научной литературы показывает, что избыточный уровень гормонов ЩЖ, регулирующих энергетический обмен, воздействуя на митохондрии, способствует образованию свободных радикалов, чрезмерное количество которых способствует развитию оксидативного стресса и повреждению тканей [11,13,16]. Установлено, что нейроны более восприимчивы, чем другие клетки, к повреждению свободными радикалами из-за большого содержания липидов в миелиновых оболочках и высокой скорости окислительного метаболизма головного мозга [7,18].…”

Section: Fig 3 the Effect Of Glyprolins On The Parameters Of The Enzy...unclassified

Effects of Glyprolins on Lipid and Protein Peroxidation in the Hypothalamic Region in Experimental Hyperthyroidism

Sergalieva,

Tsibizova,

Samotrueva

2024

BIOMEDICINE

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We investigate effects of glyproline-type neuropeptides on lipid and protein peroxidation in the hypothalamic brain region of rats under the conditions of experimental hyperthyroidism. The state of hyperthyroidism in animals was simulated by intragastric administration of sodium pentahydrate of L-thyroxine at a dose of 150 µg/kg for 21 days. The following experimental groups (n=10) were formed: 1) control group — intact animals (control); 2) animals treated with L-thyroxine sodium salt pentahydrate (hyperthyroidism); 3) animals treated with Thr-Lys-Pro-Arg-Pro-Gly-Pro (celank); 4) animals treated with Pro-GlyPro (doses of 87 and 33 µg/kg/day, respectively) intraperitoneally daily during 21 days starting one day after the last administration of sodium pentahydrate of L-thyroxine. The level of lipid peroxidation processes was assessed by the initial level of TBA-reactive products, spontaneous and ascorbate-dependent lipid peroxidation rates in hypothalamic tissue homogenate. Protein peroxidation products were determined by the reaction between oxidized amino acid residues of proteins and 2,4-dinitrophenylhydrazone. The enzymatic part of the antioxidant system of hypothalamic region was estimated by measuring the activity of superoxide dismutase and catalase. In the setting of Thr-Lys-Pro-Arg-Pro-Gly-Pro and Pro-Gly-Pro administration under experimental hyperthyroidism, the intensity of lipid and protein peroxidation processes was decreased, while the activity of antioxidant enzymes-superoxide dismutase and catalase was restored in the hypothalamic tissue. The experimental data obtained indicate that, under the conditions of experimental hyperthyroidism, Thr-Lys-Pro-Arg-Pro-Gly-Pro and Pro-Gly-Pro compounds exhibit an antioxidant and antiradical activity with respect to parameters of lipoperoxidation and oxidative modification of proteins, as well as with respect to enzymatic defense systems in the hypothalamic brain region of laboratory animals.

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Role of oxidative stress and altered thyroid hormones in unexplained infertility

Cited by 4 publications

References 16 publications

Subfertile Chinese patients with diminished ovarian reserve: An analysis of pregnancy outcomes of ART cycles

Subfertile Chinese patients with diminished ovarian reserve: An analysis of pregnancy outcomes of ART cycles

Role of oxidative stress and IL-17 induced inflammatory cytokines in thyroid carcinoma with Hashimoto's thyroiditis

Effects of Glyprolins on Lipid and Protein Peroxidation in the Hypothalamic Region in Experimental Hyperthyroidism

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