Role of Oxidative Stress in the Pathogenesis of Acute Pancreatitis

Sweiry, J H; Mann, Giovanni E.

doi:10.3109/00365529609104992

Cited by 120 publications

(65 citation statements)

References 35 publications

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“…The prevalence of lower plasma concentrations of these vitamins and trace elements in patients with chronic pancreatitis (CP) has been reported (Yadav et al, 1991;Quilliot et al, 2001). Because of a heightened oxidative modification of low-density lipoprotein (LDL) in CP (Steinberg and Witztum, 1990), accelerated atherosclerosis (Schoenberg et al, 1995;Sweiry and Mann, 1996) could be one of a number of complications associated with this condition (Quilliot et al, 2005). Carotenoids, which are lipophilic, are likely to be poorly absorbed in CP patients, but could have a role in reducing these complications.…”

Section: Introductionmentioning

confidence: 99%

Carotenoid deficiency in chronic pancreatitis: the effect of an increase in tomato consumption

et al. 2010

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Background/Objectives: Carotenoids are potentially malabsorbed in patients with chronic pancreatitis (CP). The aims of this study were: (1) to determine the prevalence of low levels of each of the major carotenoids in subjects with CP; (2) to compare carotenoids in CP subjects with or without vascular disease and (3) to test the effect of an increase in dietary lycopene intake in patients with low plasma lycopene concentration. Subjects/Methods: Simultaneous determination of carotenoids was done in 80 patients with CP and 20 healthy subjects, using high-performance liquid chromatography. Of the CP patients who had low lycopene concentration, 22 (o120 mg/l) had to consume daily 40 g tomato paste (approximately 24 mg lycopene). Results: Of these patients, 84.7% had at least one carotenoid deficiency and 27.5% had more than four carotenoid deficiencies. Low plasma concentrations in b-carotene and lycopene were correlated, in CP group, with a low body mass index (BMI), a low low-density lipoprotein (LDL) cholesterol concentration, alcohol consumption and current smoking status, whereas low plasma concentration in b-cryptoxanthine was correlated with a low BMI, a low LDL cholesterol concentration and alcohol consumption. Lycopene concentration was decreased in patients with vascular disease (171 ± 197 vs 99 ± 72 mg/l; P ¼ 0.02). After an intervention period of 8±2 months, lycopene concentration increased from 67.5±30 to 121.8±102 mg/l (P ¼ 0.025). Conclusion: Carotenoid concentrations are dramatically decreased in CP, especially lycopene in CP patients with vascular disease. Despite malabsorption, it is possible to increase lycopene plasma concentration by increasing heated tomato consumption.

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Section: Introductionmentioning

confidence: 99%

Carotenoid deficiency in chronic pancreatitis: the effect of an increase in tomato consumption

et al. 2010

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“…Hastalığın gidişatında elastaz, fosfolipaz A2, kompleman ve kinin metabolizması da aktive olmakta ve savunma hücrelerinden inflamasyon faktörleri salınarak, bu durum serbest oksijen radikalleri ile pankreas dokusundaki hasarın artmasına neden olmaktadır. [5][6][7][8] Preeklampsi patogenezinde de rol oynayan serbest oksijen radikalleri pankreatit tablosundan sorumlu olabilir.…”

Section: Discussionunclassified

A Case of HELLP Syndrome Complicated with Acute Pancreatitis

Bakar¹,

Aydın²,

Aydin³

et al. 2016

Turkiye Klinikleri J Gynecol Obst

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Ö ÖZ ZE ET T HELLP sendromu preeklampsinin bir komplikasyonu olarak gelişen hemoliz, yükselmiş karaciğer enzimleri ve düşük trombosit sayısı ile karakterize ciddi bir tablodur. Ağır preeklampsi ve eklampsi hastalarının %10-20'sinde görülür ve yüksek maternal morbidite ve mortalite ile seyreder . Pankreas dokusunun akut inflamasyonu olan akut pankreatit, morbidite ve mortaliteye yol açan ciddi sistemik komplikasyonların görüldüğü geniş spektrumlu bir hastalık olup gebelikte nadiren görümektedir. Akut pankreatitin gebelikte görülme oranı 1/1000 -1/12,000 arasında değişmekte ve hastalık olguların çoğunda üçüncü trimesterde ortaya çıkmaktadır. Bu çalışmada, 35 hafta 6 gün gestasyonel yaşı olan preeklampsi nedeni ile sezaryen ile gebeliği sonlandırılan, postoperatif HELLP sendomu geçiren ve akut pankreatit ile komplike olmuş bir olgu sunulmmuştur. Karın ağrısı, bulantı, kusma şikâyetleri olan olgularda akut panreatit gibi letal komplikasyonlara yol açabilecek bir hastalık gözden kaçırılmamalı ve tanıya yardımcı görüntüleme yöntemlerinden ve laboratuvar tetkiklerinden faydalanılmalıdır.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : HELLP sendromu; pankreatit A AB BS S T TR RA AC CT T The HELLP syndrome is a serious complication in pregnancy characterized by hemolysis, elevated liver enzymes and low platelet count occurring in 10-20% of cases preeclampsia, associated with maternal morbidity and mortality. Acute pancreatitis, defined as acute inflammation of pancreas, is a broad spectrum disease which rarely seen in pregnancy associated with serious systemic complication that causes morbidity and mortality. The incidence of acute pancreatitis in pregnancy is between 1/1000 and 1/12000. Most of the cases in pregnancy occur in third trimester. In this case report, we presented a preeclampsia with 35 weeks 6 days of gestation delivered via cesarean delivery then complicated with HELLP syndrome and acute pancreatitis. In patients with complaint of abdominal pain, nausea and vomiting diseases such as acute pancreatitis that causes lethal complications should not be missed and appropriate imaging methods and laboratory test should be used for diagnosis. K Ke ey y W Wo or rd ds s: : HELLP syndrome; pancreatitis T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i J J G Gy yn ne ec co ol l O

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“…As a result of reperfusion, occurring after ischaemia, deepening the damage to the endothelium of the blood vessels and activation of the components of the complement system, the activation of the mast cells, the intensification of the aggregation of blood platelets, which consequently leads to the formation of micro-thromboses occur. The activated cells of the immunological system secondarily cause the intensified production of the reactive form of oxygen, damaging the adjacent tissues (Sweiry & Mann 1996;Telek et al, 2001). In turn, antioxidants counteract the reactive form of oxygen in an organism.…”

Section: Oxidative Stress and Antioxidative Status In Acute Pancreatitismentioning

confidence: 99%