Role of Oxidative Stress in Celecoxib-Induced Renal Damage in Wistar Rats

Abstract

Celecoxib, a selective cyclo-oxygenase-2 (Cox-2) inhibitor, prevents the formation of prostaglandins, responsible for maintenance of renal function. Celecoxib administration may lead to renal damage. Since free radicals and antioxidant mechanisms play a significant role in renal injury; this study was designed to evaluate the role of oxidative stress in celecoxib-induced renal damage. The administration of celecoxib resulted in moderate and mild tubulointerstitial nephritis in chronic and acute group. The renal function tests were significantly altered only in the chronic group. The results in both the acute and the chronic group showed (1) a significant increase in the lipid peroxidation and in the activities of superoxide dismutase, catalase and glutathione-S-transferase and (2) a decrease in nitrite, reactive thiols and glutathione. In conclusion, our study suggests that chronic administration of celecoxib may have a damaging effect on kidney, as evident through altered histopathology and renal functions. This damage may be mediated by oxidative stress.

Effects on Renal Histology, Renal Metabolizing Enzymes and Oxidative Stress Biomarkers in Rats Administered Zerumbone Against Osteoarthritis

“…As GST catalyzes the conjugation of glutathione, the increase in GST activity would reduce glutathione levels. Thus present results showing reduced glutathione and increased GST activity corroborate each other (Gupta et al, 2007). Similarly, we found Celecoxib induced GST and reduced GSH.…”

“…Actually, celecoxib, a selective cyclo-oxygenase-2 inhibitor so that prevents the formation of prostaglandins which is responsible for maintenance of renal function, accordingly its activity may predispose to the development of renal damage (Gupta et al, 2007). Celecoxib induce significantly lipid peroxidation and the activities of glutathione-S-transferase and on contrary it decreases the reactive thiol and glutathione in the renal tissue, which indicates inversely relationship between these two biomarkers (Sozer et al, 2011).…”

Effects of celecoxib in young rats: Histopathological changes in tissues and alterations of oxidative stress/antioxidant defense system

“…Several reports have suggested the renal damage produced by celecoxib via inhibition of COX-2 (Zhang et al, 1997;Hao and Breyer, 2000;Brater, 2002;Gupta et al, 2007). Published case reports suggest that use of this drug is associated with renal effects similar to those of conventional nonselective NSAIDs (Ahmad et al, 2002).…”

Synergistic Antioxidant Activities of Eight Traditional Chinese Herb Pairs

“…The adverse effects of oxidative stress have been demonstrated in several groups of diseases, including cardiovascular disease and heart disease, 1,2) liver injury, 3) acute and chronic renal damage, 4) and cancer. 5) These negative effects are mainly caused by the formation of free radicals and mediated by free radical damage to lipids, proteins, and DNA.…”