Role of Oxidative Stress in the Clinical Outcome of Patients with Multiple Blunt Trauma

Abstract

OBJECTIVE: This prospective study evaluated serum total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI), along with the Revised Trauma Score (RTS) and Injury Severity Score (ISS), as predictors of clinical outcome in the early posttraumatic period in patients with multiple blunt trauma (MBT). METHODS: The study included 52 patients admitted to the emergency department with MBT and 40 age-and sex-matched healthy control subjects. RESULTS: The overall MBT patient mortality was 32.7% (17/52). There was no significant association between age and mortality in MBT patients, but there was a negative correlation between mortality and RTS, and a positive correlation between mortality and ISS. TOS levels were significantly higher in nonsurvivors compared with survivors. There was no correlation between TAS or OSI and survival. ISS and RTS showed positive and negative correlations with TOS level, respectively, but neither was significantly related to TAS or OSI. CONCLUSIONS: These findings suggest that TOS, as an early oxidative stress biomarker, may be an objective alternative criterion to the ISS and RTS for managing patients with MBT during the early period following traumatic injury.

Acute serum free thiols: a potentially modifiable biomarker of oxidative stress following traumatic brain injury

“…The significant contribution of non-TBI trauma to the decline in serum free thiol concentrations of the TBI group is unsurprising. Various studies have demonstrated an important role of oxidative stress in trauma such as in multiple blunt trauma and abdominal trauma [ 34 , 35 ]. A mechanism by which oxidative stress occurs after non-TBI trauma is through activation of neutrophils which can generate free radicals in a process called the ‘oxidative burst’ [ 36 ].…”

Biomarkers for differentiation of causes of respiratory distress in dogs and cats: Part 2 – Lower airway, thromboembolic, and inflammatory diseases

“…Oxidative stress has been evaluated in people in many different diseases including asthma, active and passive smoking, heart failure, renal failure, cancer, COPD, pulmonary hypertension, diabetes mellitus, ischemia and reperfusion injury, periodontal disease, blunt trauma, pneumonia, and ARDS . In large animals, changes in various biomarkers indicative of oxidative stress has been documented in a wide variety of conditions including recurrent airway obstruction in horses and various inflammatory diseases in cows and horses …”