Role of oxidative stress in the pathophysiology of bipolar disorder

Steckert, Amanda V.; Valvassori, Samira S.; Moretti, Morgana; Dal‐Pizzol, Felipe; Quevedo, Joao L De

doi:10.1007/s11064-010-0195-2

Cited by 109 publications

(69 citation statements)

References 77 publications

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“…21 Furthermore, oxidative stress plays a critical role in the pathophysiology of BD. 22 The formation of reactive oxygen species as well as the induction of signaling molecules, such as cytokines, cause the activation of MMPs, 23 which may represent a possible mechanism linking BD to the biological activation of MMP.…”

Section: Discussionmentioning

confidence: 99%

Expression of matrix metalloproteinases in patients with bipolar disorder

Chiarani

Fries

Stertz

et al. 2013

Rev. Bras. Psiquiatr.

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Objective: High cardiovascular mortality rates have been reported in patients with bipolar disorder (BD). Studies indicate that matrix metalloproteinases (MMPs) are implicated in cardiovascular diseases. We evaluated the expression pattern of MMP-2 and MMP-9 in blood from patients with BD during acute mania and after euthymia, in comparison with healthy controls. Methods: Twenty patients and 20 controls were recruited and matched for sex and age. MMP messenger RNA (mRNA) levels were measured using real-time quantitative polymerase chain reaction (PCR). Body mass index (BMI) was calculated for all subjects. Results: There were no significant differences in MMP-2 and MMP-9 mRNA expression between patients and controls. mRNA levels were not significantly different during mania and euthymia. However, MMP-2 mRNA levels were negatively associated with BMI in BD patients and positively associated with BMI in controls. There was no difference in the pattern of MMP-9 expression between patients and controls. Conclusions: Our results suggest a different pattern of association between MMP-2 and BMI in BD patients as compared with controls. Despite some study limitations, we believe that the role of MMPs in BD should be further investigated to elucidate its relationship with cardiovascular risk.

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Section: Discussionmentioning

confidence: 99%

Expression of matrix metalloproteinases in patients with bipolar disorder

Chiarani

Fries

Stertz

et al. 2013

Rev. Bras. Psiquiatr.

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“…Production of ROS and the resultant oxidative stress is believed to play a role in the pathophysiology of BD Steckert et al, 2010). The most recent meta-analysis in the field identified a number of oxidative stress markers that were impaired in BD, suggesting an underlying abnormality in in oxidative energy generation (Brown et al, 2014).…”

Section: Oxidative Stressmentioning

confidence: 99%

Alcohol use in bipolar disorder: A neurobiological model to help predict susceptibility, select treatments and attenuate cortical insult

Chitty

Lagopoulos

Hickie

et al. 2015

Neuroscience & Biobehavioral Reviews

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In a series of neurophysiological and neuroimaging studies we investigated the neurobiology related to alcohol use in young people with bipolar disorder. Impairments were identified across frontal and temporal representations of event-related potential and proton magnetic resonance spectroscopy markers; mismatch negativity and in vivo glutathione, respectively. We propose these findings reflect impairments in the Nmethyl-D-aspartate receptor and antioxidant capacity. This review seeks to place these findings within the broader literature in the context of two propositions:

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“…Whenever not effi ciently removed, an over-quota of free radicals can primarily damage mitochondrial structures as mitochondrial DNA, possibly inducing mutation in key genes involved in oxidative phosphorylation (Kato 2000 ;Clay et al 2011 ), and mitochondrial membranes ( Wallace 2005 ;Andreazza et al 2010 ) directly interfering with electron transport chain (ETC) and mitochondrial adenosine triphosphate (ATP) synthesis (Steckert et al 2010 ). Thus, in this perspective, ROS generation is strictly and reciprocally associated to mitochondrial functioning, representing, at the same time, a source and a consequence of mitochondrial dysfunction.…”

Section: +mentioning

confidence: 99%