Role of oxidative stress in the pathophysiology of <i>Toxoplasma gondii</i> infection

Dinçel, Güngör Çağdaş; Atmaca, Hasan

doi:10.1177/0394632016638668

Cited by 43 publications

(39 citation statements)

References 59 publications

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“…Toxoplasma -mediated oxidative stress (OS) is suggested to take part in the mechanism of neuropathology and neurodegeneration. [ 22 ] A pro-inflammatory immune reaction, dominated by Th1 and Th17 cytokines, particularly interferon (IFN-γ) and TNF-α, is triggered by Toxoplasma infection. [ 23 ] IFN-γ is the main and crucial cytokine for defense against T. gondii , particularly in central nervous system (CNS).…”

Section: Introductionmentioning

confidence: 99%

More than an association: Latent toxoplasmosis might provoke a local oxidative stress that triggers the development of bipolar disorder

Afifi

Jiman-Fatani

Al-Rabia

et al. 2018

J Microsc Ultrastruct

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Introduction:Toxoplasma gondii, a common parasitic infection, has a special affinity to the brain. It has a lifelong existence without an apparent clinical disease. While the etiology of bipolar disorder (BD) remains unclear, epidemiological studies suggest a role for infections. Central nervous system is particularly susceptible to oxidative stress (OS) because of its high metabolic rate and its low levels of antioxidant defenses. OS is a contributor to the initiation and progression of many neurological illnesses. OS injury is a constantly and compelling finding associated with BD and toxoplasmosis.Aim:This cross-sectional study has investigated a possible role of toxoplasma-induced OS in the development of BD.Methods:Healthy controls and BD patients were examined for anti-Toxoplasma immunoglobulin-G (IgG) and two protein (3-nitrotyrosine) and DNA (8-hydroxy-2’ deoxyguanosine [8-OHdG]) OS markers.Results:Toxoplasma positivity was higher (40%) among BD patients compared to controls (12%). Significantly higher levels of anti-Toxoplasma IgG were detected in BD patients compared to controls. Nitrotyrosine (796.7 ± 106.28) and especially 8-OHdG (20.31 ± 8.38) were significantly higher among toxo-positive BD compared to toxo-negative BD (675.97 ± 144.19 and 7.44 ± 2.86) and healthy controls (464.02 ± 134.6 and 4.17 ± 1.43).Conclusion:These findings might indicate a role for Toxoplasma infection in the development of BD, possibly through creating a highly oxidative brain environment.

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Section: Introductionmentioning

confidence: 99%

More than an association: Latent toxoplasmosis might provoke a local oxidative stress that triggers the development of bipolar disorder

Afifi

Jiman-Fatani

Al-Rabia

et al. 2018

J Microsc Ultrastruct

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“…It often induces chain reactions in the biological and chemical processes, and inflammation, lack of energy by the cells, excitotoxicity, apoptosis, and oxidant stress may be caused as a result [6]. Among the previously mentioned processes, oxidative stress plays a pivotal role [7]. The promotion of inflammation and other reactions leads to the exacerbation of oxidative stress because oxidation aggravates inflammation and other reactions, which is a vicious cycle [8].…”

Section: Introductionmentioning

confidence: 99%

Rhein exhibits antioxidative effects similar to Rhubarb in a rat model of traumatic brain injury

Xia

et al. 2017

BMC Complement Altern Med

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BackgroundThe brain is secondarily harmed by pathological, physiological, and biological reactions that are caused by traumatic brain injury (TBI). Rhein, a significant composition of Rhubarb, is a well-known traditional Chinese treatment method and has a strong oxidation-resisting characteristic, but Rhein’s mechanism remains unclear.MethodsThis study aimed to identify Rhein in the brain tissues of TBI model of rats, and confirm whether Rhein induced an antioxidative effect similar to its parent medicine, Rhubarb. First, the ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was applied to identify Rhein in the brain tissue of the controlled cortical impact (CCI) rats after intra-gastric administration of Rhubarb. Further, for the purpose of calculating the oxidant stress of the CCI rats, the malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and glutathione disulfide (GSSG), as well as the proportion of glutathione (GSH)/GSSG were measured in the brain tissues.ResultsThe results showed that Rhein was absorbed in the brain tissues of CCI rats. Rhubarb and rhein elevated the SOD, CAT activities, GSH level, and GSH/GSSG ratio, and diminished the MDA and GSSG levels.ConclusionThe data demonstrated that Rhubarb and Rhein had the potential to be used as a neuroprotective drug for TBI, and that Rhein induced an antioxidative effect similar to its parent medicine, Rhubarb.

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“…The results of the present study illustrated that MDA serum level was high in patients with acute toxoplasmosis compared with controls due to induction of oxidative stress and lipid peroxidation. Dincel and Atmaca's study (19) confirmed that high level of MDA is associated with acute toxoplasmosis due to induction of oxidative stress and reduction of endogenous anti-oxidant capacity.…”

Section: Discussionmentioning

confidence: 84%

Toxoplasmosis and Risk of Endothelial Dysfunction: Role of Oxidative Stress and Pro-Inflammatory Mediators

Al-Kuraishy

Al-Kuraishi

Al-Windy

et al. 2020

Arch Clin Infect Dis

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Background: Infection with Toxoplasma gondii (T. gondii) leads to activation of T-helper cells (Th-1 and Th-2) which are involved in the synthesis and release of different cytokines which may lead to endothelial dysfunction. Objectives: To evaluate the endothelial function in patients with acute toxoplasmosis. Methods: This case-control study involved 31 patients with toxoplasmosis aged 19 -47 years matched with 20 healthy subjects. Anti-T. gondii antibody (IgG, IgM, IgA) was determined by direct antigen-antibody reaction. Interleukin-6(IL-6), endothelin-1 (ET-1) and human malondialdehyde (MDA) serum levels were measured. Results: IgM, IgG and IgA levels were high in the infected patients compared with controls (P < 0.01). Furthermore, IL-6 serum level was high in the infected patients compared with controls (P < 0.01). In addition, ET-1 level was high in acute toxoplasmosis (7.29 ± 4.59 pg/mL) compared with controls (3.11 ± 1.69 pg/mL) (P < 0.01). In addition, MDA serum level was high (9.34 ± 4.17 nmol/mL) compared with controls (2.87 ± 1.13 nmol/mL), (P < 0.01). In acute toxoplasmosis IgM serum level was significantly correlated with IgG (r = 0.55, P = 0.001), IgA (r = 0.57, P = 0.0008), IL-6 (r = 0.45, P = 0.01), ET-1 (r = 0.51, P = 0.003) and MDA (r = 0.85, P = 0.0001). Conclusions: Acute toxoplasmosis is associated with significant oxidative stress and pro-inflammatory changes which contribute to development of endothelial dysfunction.

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Role of oxidative stress in the pathophysiology of Toxoplasma gondii infection

Cited by 43 publications

References 59 publications

More than an association: Latent toxoplasmosis might provoke a local oxidative stress that triggers the development of bipolar disorder

More than an association: Latent toxoplasmosis might provoke a local oxidative stress that triggers the development of bipolar disorder

Rhein exhibits antioxidative effects similar to Rhubarb in a rat model of traumatic brain injury

Toxoplasmosis and Risk of Endothelial Dysfunction: Role of Oxidative Stress and Pro-Inflammatory Mediators

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