Role of oxidized low density lipoprotein in atherogenesis.

Witztum, Joseph L.; Steinberg, Daniel

doi:10.1172/jci115499

Cited by 2,519 publications

(1,335 citation statements)

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“…Fruits and vegetables are rich sources of antioxidants, which are thought to inhibit oxidation of lowdensity lipoprotein (LDL) cholesterol, a process that is considered to be a prerequisite for atherosclerosis (Witztum & Steinberg, 1991). Recently, attention has been focused on the possible cardio-protective and anticarcinogenic properties of flavonoids, a group of polyphenolic compounds that occur naturally in fruits and vegetables, tea and red wine (Hollman & Katan, 1999).…”

Section: Introductionmentioning

confidence: 99%

The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies

2003

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Objective: To assess the association of dietary flavonol intake with the subsequent risk of coronary heart disease (CHD) mortality. Design: Meta-analysis of prospective cohort studies published before September 2001. Studies were identified by MEDLINE and EMBASE searches and by scanning relevant reference lists. The following information was extracted from published reports: size of cohort, mean age, mean duration of follow-up, number of fatal CHD events, mean flavonol intake, main sources of flavonol intake, degree of adjustment for potential confounders, and the relation of CHD mortality to dietary flavonol intake measured at baseline. Results: Seven prospective cohorts of men and women were identified including a total of 2087 fatal CHD events. Comparison of individuals in the top third with those in the bottom third of dietary flavonol intake yielded a combined risk ratio of 0.80 (95% CI 0.69-0.93) after adjustment for known CHD risk factors and other dietary components. Conclusion: This overview of prospective cohort studies indicates that high dietary intake of flavonols from a small number of fruits and vegetables, tea and red wine may be associated with a reduced risk from CHD mortality in free-living populations.

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Section: Introductionmentioning

confidence: 99%

The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies

2003

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“…There is increasing evidence from experimental studies that free radical-mediated damage may play a role in the aetiology of cardiovascular disease and that antioxidants may act in preventing this damage (Steinberg et al, 1989;Witztum & Steinberg, 1991;Esterbauer & Ramos, 1995). Tea is a rich source of avonoids and the bene®cial health effects of tea consumption have been related to the antioxidant activity of these tea¯avonoids (Ho et al, 1993;Salah et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Bioavailability of catechins from tea: the effect of milk

et al. 1998

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Objectives: To assess the blood concentration of catechins following green or black tea ingestion and the effect of addition of milk to black tea. Design: Twelve volunteers received a single dose of green tea, black tea and black tea with milk in a randomized cross-over design with one-week intervals. Blood samples were drawn before and up to eight hours after tea consumption. Setting: The study was performed at the Unilever Research Vlaardingen in The Netherlands. Subjects: Twelve healthy adult volunteers (7 females, 5 males) participated in the study. They were recruited among employees of Unilever Research Vlaardingen. Interventions: Green tea, black tea and black tea with semi-skimmed milk (3 g tea solids each). Results: Consumption of green tea (0.9 g total catechins) or black tea (0.3 g total catechins) resulted in a rapid increase of catechin levels in blood with an average maximum change from baseline (CVM) of 0.46 mmol/l (13%) after ingestion of green tea and 0.10 mmol/l (13%) in case of black tea. These maximum changes were reached after (mean (s.e.m.)) t 2.3 h (0.2) and t 2.2 h (0.2) for green and black tea respectively. Blood levels rapidly declined with an elimination rate (mean (CVM)) of t 1a2 4.8 h (5%) for green tea and t 1a2 6.9 h (8%) for black tea. Addition of milk to black tea (100 ml in 600 ml) did not signi®cantly affect the blood catechin levels (areas under the curves (mean (CVM) of 0.53 h. mmol/l (11%) vs 0.60 h. mmol/l (9%) for black tea and black tea with milk respectively. Conclusion: Catechins from green tea and black tea are rapidly absorbed and milk does not impair the bioavailability of tea catechins.

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“…3 Accumulation of low-density lipoprotein (LDL) occurs in the intima of the arterial wall where it may become oxidized (oxLDL) by multiple mechanisms. 4,5 OxLDL stimulates monocyte infiltration, as well as smooth muscle cell migration and proliferation in plaques. 6 Moreover, it affects the synthesis and action of several inflammatory circulating mediators such as C-reactive protein (CRP), interleukin (IL)-6, and tumor necrosis factor (TNF)-α.…”

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Low levels of IgG autoantibodies against the apolipoprotein B antigen p210 increases the risk of cardiovascular death after carotid endarterectomy

Asciutto¹,

Dias²,

Edsfeldt³

et al. 2015

Atherosclerosis

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Low levels of IgG autoantibodies against the apolipoprotein B antigen p210 increases the risk of cardiovascular death after carotid endarterectomy.Asciutto, Giuseppe; Dias, Nuno; Edsfeldt, Andreas; Alm, Ragnar; Nordin Fredrikson, Gunilla; Goncalves, Isabel; Nilsson, Jan Link to publication Citation for published version (APA): Asciutto, G., Dias, N., Edsfeldt, A., Alm, R., Nordin Fredrikson, G., Goncalves, I., & Nilsson, J. (2015). Low levels of IgG autoantibodies against the apolipoprotein B antigen p210 increases the risk of cardiovascular death after carotid endarterectomy. Atherosclerosis, 239(2), 289-294. DOI: 10.1016289-294. DOI: 10. /j.atherosclerosis.2015 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Methods: Native (nat) and malondialdehyde (MDA)-modified apoB p210 autoantibodies (IgM-p210nat, IgG-p210nat, IgM-p210MDA and IgG-p210MDA) were analyzed by ELISA from plasma samples of 351 patients at the time they underwent CEA. The incidence of postoperative CV events was assessed using national registers.Results: A total of 52 non-fatal and 15 fatal CV events were registered during the follow-up period (35.1 ± 16.7 months). Patients who suffered from a fatal CV event had significantly lower plasma levels of IgG-p210nat and IgG-p210MDA. Kaplan-Meier curves of event-free survival showed increased CV mortality in patients with levels of IgG-p210nat and IgGp210MDA below the median (Log Rank 7.813, p .005 and 9.105, p .003 respectively). The association between low levels of p210 IgG and fatal post-operative CV events remained significant when adjusting for age, sex, total cholesterol, HDL cholesterol, smoking habits and hypertension in a Cox Proportional Hazard model (hazard ratios (HR) IgG-p210nat below median: HR 6.7 (95% C.I. 1.5-30.6, p .013) and IgG-p210MDA below median: HR 7.8 (95% C.I. 1.7-35.5, p .008).Conclusions: The present findings support the notion that autoantibodies against LDL antigens are involved in the atherosclerotic disease process and suggest that CEA patients with low levels of IgG-p210nat and IgG-p210MDA have an increased risk of post-operative CV death.

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Role of oxidized low density lipoprotein in atherogenesis.

Cited by 2,519 publications

References 59 publications

The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies

The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies

Bioavailability of catechins from tea: the effect of milk

Low levels of IgG autoantibodies against the apolipoprotein B antigen p210 increases the risk of cardiovascular death after carotid endarterectomy

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