Role of oxygen in the cellular damage induced by re-oxygenation of hypoxic heart

Guarnieri, Carlo; Flamigni, Flavio; Caldarera, Claudio Marcello

doi:10.1016/0022-2828(80)90081-4

Cited by 518 publications

(123 citation statements)

References 25 publications

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“…This provides direct support for the hypothesis that superoxide may be closely related to the pathogenesis of myocardial defects, in line with earlier findings indicating the involvement of active oxygen radicals in reperfusion injury (2). Previous studies showed that reoxygenation increases lipid peroxides in ischemic myocardium, and suggested that the increase may be related with reperfusion injury (19)(20)(21)(22). Which sources of active oxygen production may play roles in reperfused ischemic myocardium remains con troversial, but several authors have described granulo cytes to be the main source of superoxide in animals with myocardial ischemia and reperfusion (23).…”

Section: Discussionsupporting

confidence: 89%

Cypridina Luciferin Analog Reduces the Incidence of Ischemia/Reperfusion-Induced Ventricular Fibrillation

Kanashiro

Goto

Sakamoto

1993

Japanese Journal of Pharmacology

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ABSTRACT-A Cypridina luciferin analog (CLA), considered to be a sensitive and specific agent for the assay of superoxide, was assessed in isolated hearts for its effects on ischemia/reperfusion injury. Hearts of anesthetized male Wistar rats were isolated and perfused with a modified Krebs-Henseleit bicarbonate buffer to serve as non-recirculating working heart preparations. After 15 min of perfusion to achieve stabil ity, they underwent 20 min of global ischemia and were then reperfused for 30 min with or without 250 uM of CLA, dissolved in the perfusate. The incidence of ventricular fibrillation was only 13% in the CLA group, whereas it was 88°10 in the controls. The CLA treatment was further associated with significantly increased left ventricular developed pressure and cardiac output; and in contrast, the left ventricular end diastolic pressure was significantly reduced, as compared with the control group. Thiobarbiturate reacting substance content in the hearts of the CLA group was significantly decreased (27.5± 2.4 versus 36.9±9.7 tmol/g dry weight). This study thus indicates that CLA may be useful for alleviating ischemia/reperfusion injury (reperfusion-induced arrhythmia and damage to heart function) involving free radicals.

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Section: Discussionsupporting

confidence: 89%

Cypridina Luciferin Analog Reduces the Incidence of Ischemia/Reperfusion-Induced Ventricular Fibrillation

Kanashiro

Goto

Sakamoto

1993

Japanese Journal of Pharmacology

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“…During MI, SOD and catalase are structurally and functionally impaired by free radicals resulting in myocardial damage. The decrease in SOD and catalase may be due to the involvement of superoxide and hydrogen peroxide free radicals in myocardial cell damage mediated by ISO (Guarnieri et al, 1980). Prior treatment with morin improved the activities of SOD and catalase by scavenging superoxide and hydrogen peroxides produced by ISO.…”

Section: Discussionmentioning

confidence: 96%

Morin, A Flavonoid, On Lipid Peroxidation And Antioxidant Status In Experimental Myocardial Ischemic Rats

Al‐Numair¹,

Govindasamy²,

Alsaif³

et al. 2014

Afr. J. Trad. Compl. Alt. Med.

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Background: Myocardial infarction affects a large population in the world. Lipid peroxide metabolism plays an important role in the pathology of myocardial infarction. Objective: The present study was designed to investigate the antioxidant potential of morin, a flavonoid in isoproterenol (ISO)-induced myocardial infarction (MI), in rats. Materials and Methods: Male albino Wistar rats were pre-treated with morin (40 mg/kg), daily for a period of 30 days. After the treatment period, ISO (85 mg/kg), was subcutaneously injected in rats at an interval of 24 h for 2 days. R e s u l t s : ISO-administered rats showed elevated levels of thiobarbituric acid reactive substances (TBARS), and lipid hydro-peroxide (LOOH), in plasma and heart. Pretreatment with morin, the above changes were significantly reduced to near normal level. ISOadministered rats showed decrease in the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) in heart. In addition, decrease the levels non enzymatic antioxidants such as reduced glutathione (GSH), vitamin C and vitamin E in plasma and heart while ceruloplasmin in plasma. Conclusion: Pretreatment with morin, reversed these above biochemical changes towards normalcy. These findings revealed that, the morin possess antioxidant activity in experimentally induced cardiac toxicity.

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“…This is followed by membrane lipid peroxidation (Guarnieri et al, 1980) and loss of intracellular K+ attributed to an increase in membrane permeability to K + ions (Vleugels & Carmeliet, 1976;Coraboeuf et al, 1976).…”

Section: Introductionmentioning

confidence: 99%

Effect of trimetazidine on membrane damage induced by oxygen free radicals in human red cells.

Maridonneau‐Parini¹,

Harpey²

1985

Brit J Clinical Pharma

144

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The effect of trimetazidine, 1‐(2, 3, 4 trimethoxybenzyl)piperazine di‐ hydrochloride, on membrane damage induced by oxygen free radicals in red cells was studied in seven healthy volunteers after oral administration. Red cells collected prior to and after a 7 day treatment period with trimetazidine were incubated in the presence of phenazine methosulphate (an intracellular oxygen free radical generator) and diethyldithiocarbamate (a Cu‐Zn superoxide dismutase inhibitor). The loss of intracellular K+ induced by oxygen free radicals and the membrane content of peroxidated lipids were significantly reduced in red cells collected after the period of treatment. These results indicate a potent antioxidant activity of trimetazidine which could explain its cardioprotective role during ischaemic and reperfusion phases in which oxygen free radicals are generated and probably implicated in the genesis of cardiac cell injury.

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Role of oxygen in the cellular damage induced by re-oxygenation of hypoxic heart

Cited by 518 publications

References 25 publications

Cypridina Luciferin Analog Reduces the Incidence of Ischemia/Reperfusion-Induced Ventricular Fibrillation

Cypridina Luciferin Analog Reduces the Incidence of Ischemia/Reperfusion-Induced Ventricular Fibrillation

Morin, A Flavonoid, On Lipid Peroxidation And Antioxidant Status In Experimental Myocardial Ischemic Rats

Effect of trimetazidine on membrane damage induced by oxygen free radicals in human red cells.

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