Role of P14 and MGMT Gene Methylation in Hepatocellular Carcinomas: a Meta-analysis

Li, Chengcheng; Yu, Zhuang; Cui, Lianhua; Piao, Jin-Mei; Li, Meng

doi:10.7314/apjcp.2014.15.16.6591

Cited by 9 publications

(11 citation statements)

References 32 publications

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“…[ 5 – 7 ] Aberrant promoter methylation of tumor suppressor genes (TSGs), such as P14 or O6-methylguanine-DNA methyltransferase, is reported to be involved in HCC development. [ 8 ] Located on human chromosome 9p21, the p16 gene, a family of regulators of the cell cycle, consisting of 3 exons and 2 introns, is a cyclin-dependent kinase inhibitor and plays a key role in cell cycle regulation. [ 9 , 10 ] The loss of p16 expression through methylation has revealed that p16 acts as a TSG, suggesting the frequent inactivation of this gene in human tumors.…”

Section: Introductionmentioning

confidence: 99%

p16 Methylation was associated with the development, age, hepatic viruses infection of hepatocellular carcinoma, and p16 expression had a poor survival

Zhang

et al. 2017

Medicine

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Section: Introductionmentioning

confidence: 99%

p16 Methylation was associated with the development, age, hepatic viruses infection of hepatocellular carcinoma, and p16 expression had a poor survival

Zhang

et al. 2017

Medicine

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“…Many other studies also suggested that P14 ARF methylation was higher in liver cancer tissue than in normal tissue [ 20 – 23 ]. The meta-analysis results reported by Li indicated that primary liver cancer risk was associated with P14 ARF gene DNA methylation level [ 24 ]. All of these research results revealed that P14 ARF gene DNA methylation may be associated with primary liver cancer occurrence.…”

Section: Discussionmentioning

confidence: 99%

The Correlation Relationship between P14ARF Gene DNA Methylation and Primary Liver Cancer

2015

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BackgroundPrimary liver cancer is a common malignant tumor that causes serious damage to human health. DNA methylation is common in epigenetics. DNA methylation plays an important role in the process of primary liver cancer occurrence and development. The P14ARF gene is an important tumor suppressor gene. It was found that P14ARF methylation is associated with the degree of malignancy in multiple tumors. Therefore, this study aimed to investigate the relationship between P14ARF methylation level and primary liver cancer malignant degree.Material/MethodsCarcinoma tissues and adjacent tissues were collected from 87 primary liver cancer patients. Pyrosequencing was applied to obtain P14ARF methylation. Real-time PCR was used to detect P14ARF mRNA level.ResultsP14ARF methylation level in cancerous tissue was significantly higher than in the adjacent tissue (t=76.54, P<0.001). P14ARF methylation showed no significant difference in patients with different age, sex, smoking status, or drinking status. It did not present an obvious difference in tumors with different size. Its methylation level increased following the improvement of TNM stage (P<0.05). Compared with the adjacent tissue, P14ARF mRNA in carcinoma tissue decreased by 31% (t=28.91, P<0.001). P14ARF methylation showed a significant negative correlation with mRNA expression in cancerous tissue (r=−0.43, P<0.01).ConclusionsP14ARF mRNA level is regulated by DNA methylation in primary liver cancer. P14ARF gene DNA methylation may be associated with the occurrence of primary liver cancer occurrence and TNM staging.

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“…They did not detect methylation of O 6 -MGMT in any of their samples (Figure 5) [78]. Another meta-analysis study reported a weak (non-significant) association between O 6 -MGMT methylation and HCC risk in a Chinese population (OR: 2.42 with a 95% CI (confidence interval) of 0.76-7.73) but not in a Western population (OR: 0.06) [79], which supports that O 6 -MGMT methylation changes are unlikely to play a role in HCC disparities.…”

Section: O 6 -Mgmt Dna Repair Pathwaymentioning

confidence: 94%

“…In another meta-analysis, subgroup analysis based on ethnicity revealed that methylation of p14 ARF was tightly associated with the risk of HCC in both the Chinese and Western populations (OR: 7.74 vs. 3.60). However, the difference in ORs was not directly compared between the Chinese and Western populations [79].…”

Section: The Prb and Cell Cycle Pathwaysmentioning

confidence: 99%

Sex and Race-Related DNA Methylation Changes in Hepatocellular Carcinoma

Siwko

Tsai

2021

IJMS

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Hepatocellular carcinoma (HCC) is the sixth most common cancer and fourth leading cause of cancer-related death worldwide. The number of HCC cases continues to rise despite advances in screening and therapeutic inventions. More importantly, HCC poses two major health disparity issues. First, HCC occurs more commonly in men than women. Second, with the global increase in non-alcoholic fatty liver diseases (NAFLD), it has also become evident that HCC is more prevalent in some races and/or ethnic groups compared to others, depending on its predisposing etiology. Most studies on HCC in the past have been focused on genetic factors as the driving force for HCC development, and the results revealed that genetic mutations associated with HCC are often heterogeneous and involve multiple pathogenic pathways. An emerging new research field is epigenetics, in which gene expression is modified without altering DNA sequences. In this article, we focus on reviewing current knowledge on HCC-related DNA methylation changes that show disparities among different sexes or different racial/ethnic groups, in an effort to establish a point of departure for resolving the broader issue of health disparities in gastrointestinal malignancies using cutting-edge epigenetic approaches.

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Role of P14 and MGMT Gene Methylation in Hepatocellular Carcinomas: a Meta-analysis

Cited by 9 publications

References 32 publications

p16 Methylation was associated with the development, age, hepatic viruses infection of hepatocellular carcinoma, and p16 expression had a poor survival

p16 Methylation was associated with the development, age, hepatic viruses infection of hepatocellular carcinoma, and p16 expression had a poor survival

The Correlation Relationship between P14ARF Gene DNA Methylation and Primary Liver Cancer

Sex and Race-Related DNA Methylation Changes in Hepatocellular Carcinoma

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