Role of pepsin and pepsinogen: Linking laryngopharyngeal reflux with otitis media with effusion in children

Luo, Huanan; Yang, Qimei; Sheng, Ying; Wang, Zhenghui; Zhang, Qing; Yan, Jing; Hou, Jin; Zhu, Kangshun; Cheng, Ying; Wang, Botao; Xu, Yan; Zhang, Xianghong; Ren, Xiaoyong; Xu, Min

doi:10.1002/lary.24538

Cited by 55 publications

(47 citation statements)

References 23 publications

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“…CXCR4 encodes C-X-C chemokine receptor 4, a member of GPCR receptor family which is found to be overexpressed in many cancer types such as HNSCC. While Luo et al found CXCR4 overexpression to be associated with metastatic LSCC [22], no differences in CXCR4 expression were observed between cancer tissue and counterpart normal tissue in the present study, and no relationship was found with cancer lymph node metastasis. The reason for this discrepancy may be that while both Tan et al [38] and Luo et al [22] found their group of laryngeal cancer samples to contain more lymph node positive samples, 63% of the samples in our group were lymph node negative.…”

Section: Discussioncontrasting

confidence: 96%

New miRNA expression abnormalities in laryngeal squamous cell carcinoma

Cybula

Wieteska

Józefowicz-Korczyńska

et al. 2016

CBM

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Abstract. BACKGROUND:Although the development of novel diagnostic and treatment strategies concerning laryngeal cancer is highly intensive, the survival rate remains virtually unchanged. Small non-coding RNAs appear to be very promising biomarkers -and so remain the focus of extensive investigation in laryngeal cancer. OBJECTIVE: We examined the expression of five miRNA and five genes related to cancer whether they could be potential laryngeal cancer biomarkers. METHODS:We performed an analysis in 47 patients diagnosed with laryngeal cancer. The qPCR technique was used to investigate the expression profile. RESULTS: While miR-21-3p and miR-525-5p were found to be significantly up-regulated, miR-139-3p and miR-885-5p expression is lower in laryngeal cancer. Moreover, PIK3R1 and HACE1 were found to be also down-regulated. CONCLUSIONS: The change in miRNA expression is frequent than the expression of other tested genes. The expression of passenger strands such as miR-21-3p and miR-139-3p, which are rarely investigated, is also significantly affected in laryngeal cancer. While PIK3R1, HACE1, miR-139-3p, and miR-885-5p may act as tumor suppressor genes in the studied tumour type, miR-21-3p and miR-525-5p seem to have oncogenic properties. Our findings suggest that miR-885-5p and PIK3R1 are the best indicators for the classification of laryngeal cancer tissue and normal mucosa.

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Section: Discussioncontrasting

confidence: 96%

New miRNA expression abnormalities in laryngeal squamous cell carcinoma

Cybula

Wieteska

Józefowicz-Korczyńska

et al. 2016

CBM

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“…42,43 Unresponsiveness after PPI treatment in patients with GERD is also associated with poor compliance, psychiatric comorbidities, and functional gastrointestinal disorders. 44,45 After taking PPI, gastric acid secretion is reduced, and the pH in the stomach rises to 4.0 or higher, inhibiting the activation of pepsinogen. 41,46 The current basic principle of drug therapy against GERD is to reduce gastric acid secretion and indirectly reduce the production of pepsin, thereby reducing the amount of gastric acid and pepsin refluxed to the esophagus, throat and other parts, resulting in significantly reduced clinical symptoms and the mucosa damages to the reflux site in GERD patients.…”

Section: Discussionmentioning

confidence: 99%

Salivary Pepsin as an Intrinsic Marker for Diagnosis of Sub-types of Gastroesophageal Reflux Disease and Gastroesophageal Reflux Disease-related Disorders

Wang

Lang

et al. 2020

J Neurogastroenterol Motil

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Background/AimsTo determine the value of salivary pepsin in discriminating sub-types of gastroesophageal reflux disease (GERD) and GERD-related disorders. MethodsOverall, 322 patients with different sub-types of GERD and 45 healthy controls (HC) were studied. All patients took Gastroesophageal Reflux Disease Questionnaire (GerdQ) and underwent endoscopy and 24-hour esophageal pH monitoring and manometry. Salivary pepsin concentration (SPC) was detected by using colloidal gold double-antibody immunological sandwich assay. Oral esomeprazole treatment was administrated in the patients with non-erosive reflux disease (NERD) and extra-esophageal symptoms (EES). ResultsCompared to HC, patients with erosive esophagitis, NERD, EES, EES plus typical GERD symptoms, or Barrett's esophagus had a higher prevalence of saliva and SPC (all P < 0.001). There was no significant difference in the positive rate for pepsin in patients with functional heartburn or GERD with anxiety and depression, compared to HC. After esomeprazole treatment, the positive rate and SPC were significantly reduced in NERD (both P < 0.001) and in EES (P = 0.001 and P = 0.002, respectively). Of the 64 NERD patients, 71.9% (n = 46) were positive for salivary pepsin, which was significantly higher than the rate (43.8%, n = 28) of pathological acid reflux as detected by 24-hour esophageal pH monitoring (P = 0.002). ConclusionsSalivary pepsin has an important significance for the diagnosis of GERD and GERD-related disorders. Salivary pepsin and 24-hour esophageal pH monitoring may complement with each other to improve the diagnostic efficiency. (J Neurogastroenterol Motil 2020;26:74-84)

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“…About one-third of children who have pepsin in their middle ear fluid are reported to have abnormal MII-pH investigations [57]. Pepsin and pepsinogen in middle ear effusion are probably caused by laryngopharyngeal reflux and may be involved in the pathogenesis of otitis media [58]. However, little is known about the esophageal reflux symptoms these children do or do not present, the results of reflux tests in those without pepsin in the middle air fluid, the long-term outcome and the impact of reflux therapy.…”

Section: Ger(d) and Other Manifestationsmentioning

confidence: 99%

An updated review on gastro-esophageal reflux in pediatrics

Vandenplas¹,

Hauser

2015

Expert Review of Gastroenterology & Hepatology

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Comprehensive guidelines for the diagnosis and management of gastro-esophageal reflux (GER) and GER disease (GERD) were developed by the European and North American Societies for Pediatric Gastroenterology, Hepatology and Nutrition. GERD is reflux associated with troublesome symptoms or complications. The recognition of GER and GERD is relevant to implement best management practices. A conservative management is indicated in infants with uncomplicated physiologic reflux. Children with GERD may benefit from further evaluation and treatment. Since the publications of the European and North American Societies for Pediatric Gastroenterology, Hepatology and Nutrition guidelines in 2009, no important novelties in drug treatment have been reported. Innovations are mainly restricted to the management of regurgitation in infants. During the last 5 years, pros and cons of multichannel intraluminal impedance have been highlighted. However, overall 'not much has changed' in the diagnosis and management of GER and GERD in infants and children.

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Role of pepsin and pepsinogen: Linking laryngopharyngeal reflux with otitis media with effusion in children

Abstract: 3b.

Cited by 55 publications

References 23 publications

New miRNA expression abnormalities in laryngeal squamous cell carcinoma

New miRNA expression abnormalities in laryngeal squamous cell carcinoma

Salivary Pepsin as an Intrinsic Marker for Diagnosis of Sub-types of Gastroesophageal Reflux Disease and Gastroesophageal Reflux Disease-related Disorders

An updated review on gastro-esophageal reflux in pediatrics

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