Role of Periarticular Liposomal Bupivacaine Infiltration in Patients Undergoing Total Knee Arthroplasty — A Meta-analysis of Comparative Trials

Liposomal bupivacaine versus traditional bupivacaine for pain control after total hip arthroplasty

“…[9,10] Liposomal bupivacaine (EXPAREL) is a prolonged-release formulation of bupivacaine indicated for single-dose administration into the surgical site to produce postsurgical analgesia. [11,12] Several studies have suggested that liposomal bupivacaine significantly alleviates pain and improves quality outcomes in THA patients. [3] Other studies have drawn an opposite conclusion that liposomal bupivacaine has similar pain control efficacy while increasing the costs for THA patients.…”

Comparison of periarticular anesthesia with liposomal bupivacaine with femoral nerve block for pain control after total knee arthroplasty

“…Wu et al [14] preferred LB than standard bupivacaine due to the long duration anesthesia effects. However, Singh et al [30] revealed that the anesthetic effects of LB infiltration need to further identified.…”

“…This outcome is inconsistent with previous meta-analysis (SMD = 0.207, 95%CI 0.095–0.319). [30] FNB may delay discharge period due to the motor weakness. Sharma et al [31] recently reported that FNB after TKA is associated with quadriceps weakness and higher rate of postoperative falls, thus delaying patient discharge.…”

“…When comparing LB with standard bupivacaine, there was no significant difference between the lengths of hospital stay. [30] …”

The Efficacy of Liposomal Bupivacaine in Lumbar Spine Surgery

“…The use of LB in Total Knee Arthroplasty (TKA) has been heavily investigated with studies demonstrating varying results. A few studies have demonstrated an efficacy of LB close to that of regional femoral blockade and others have shown that it can significantly decrease postoperative narcotic use, length of stay, and postoperative Visual Analog Scale (VAS) scores [10][11][12][13][14][15][16][17][18][19][20][21][22][23]. Although many studies have shown the potential advantages of its use, many other studies have exhibited no benefit of its use in TKA The Efficacy of Liposomal Bupivacaine in Lumbar Spine Surgery…”