Role of Perinatal Adversities on Tic Severity and Symptoms of Attention Deficit/Hyperactivity Disorder in Children and Adolescents With a Tic Disorder

Bos-Veneman, Netty G. P.; Kuin, Anne; Minderaa, Ruud B.; Hoekstra, Pieter J.

doi:10.1097/dbp.0b013e3181cc7cbc

Cited by 26 publications

(31 citation statements)

References 30 publications

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“…Pregnancy complications which included hypertension, infections, (pre)eclampsia, psychosocial stress, or diabetes mellitus were reported to be associated with greater tic severity at a single time point as measured by the Yale Global Tic Severity Scale (YGTSS) [27]. However, these pregnancy complications were found to be associated with lower mean compulsive CYBOCS ratings in these patients [28].…”

Section: Resultsmentioning

confidence: 99%

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Prenatal risk factors for Tourette Syndrome: a systematic review

Chao

Pringsheim

2014

BMC Pregnancy Childbirth

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BackgroundTourette Syndrome (TS) appears to be an inherited disorder, although genetic abnormalities have been identified in less than 1% of patients, and the mode of inheritance is uncertain. Many studies have investigated environmental factors that might contribute to the onset and severity of tics and associated comorbidities such as obsessive compulsive disorder (OCD) and attention deficit hyperactive disorder (ADHD). A systematic review and qualitative analysis were performed to provide a broad view of the association between pre- and perinatal factors and TS.MethodsThe Medline, Embase and PsycINFO databases were searched using terms specific to Tourette’s syndrome and keywords such as “pregnancy”, “prenatal”, “perinatal”, “birth” and “neonatal”. Studies were limited to studies on human subjects published in English or French through October 2012.Results22 studies were included. Studies were of limited methodological quality, with most samples derived from specialty clinics, and most exposures ascertained retrospectively. The majority of the results for demographic factors of parents, including age, education, socioeconomic status, and marital status, revealed no significant association with the onset of TS, or the presence of comorbidity. Many factors were reported to be significantly associated with the onset of TS, the presence of comorbidity and symptom severity, but the most consistently reported factors were maternal smoking and low birth weight.ConclusionsThere are few studies evaluating the relationship between pre and perinatal events and TS, and existing studies have major limitations, including the use of clinic rather than epidemiologically derived samples, retrospective data collection on pre and perinatal events and multiple hypothesis testing without appropriate statistical correction. The mechanism by which prenatal and perinatal adversities could lead to TS onset or symptom severity is unknown, but may be related to changes in the dopaminergic system as a result of early brain injury.

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Section: Resultsmentioning

confidence: 99%

“…More severe ADHD rating scale scores, measured with the parent version of the ADHD Rating Scale, were associated with maternal smoking (smoking versus non-smoking: 26.4 ± 10.1 versus 19.1 ± 10.9, p = 0.05) [27]. This association was more prominent when there was a positive family history of mental disorders (p = 0.04) [27].…”

Section: Resultsmentioning

confidence: 99%

Prenatal risk factors for Tourette Syndrome: a systematic review

Chao

Pringsheim

2014

BMC Pregnancy Childbirth

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“…Smoking during pregnancy has been related to neurodevelopmental disorders, including ADHD [13][14][15][16][17][18][19][20]. Prenatal maternal smoking has been associated with increased tic severity [21] and comorbid ADHD or OCD [22,23], but the studies are few with inconsistent results [21][22][23][24][25]. The inconsistencies could be explained by relatively small sample sizes, retrospective data collection, limited consideration for confounding factors, inconsistent study populations and outcome definitions [3,4,[21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 86%

“…Gene-environmental interactions in the etiology of TS have not been a major focus of research yet. However, BosVeneman et al [24] suggested that the relationship between in utero smoking exposure and ADHD symptom severity in children with TS or chronic tic disorder was more pronounced in children with a positive family history of mental disorders. This could indicate that gene-environmental interactions affect the TS/ADHD phenotype.…”

Section: Discussionmentioning

confidence: 99%

Prenatal Maternal Smoking and Tourette Syndrome: A Nationwide Register Study

Leivonen

Chudal

Joelsson

et al. 2015

Child Psychiatry Hum Dev

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This is the first nationwide register-based study to examine the relationship between prenatal maternal smoking and Tourette syndrome. A total of 767 children diagnosed with Tourette syndrome were identified from the Finnish Hospital Discharge Register. Each case was matched to four controls. Information on maternal smoking during pregnancy was obtained from the Finnish Medical Birth Register. Conditional logistic regression models were used for statistical analyses. Prenatal maternal smoking was associated with Tourette syndrome when comorbid with ADHD (OR 4.0, 95 % CI 1.2-13.5, p = 0.027 for exposure during first trimester, OR 1.7, 95 % CI, 1.05-2.7, p = 0.031 for exposure for the whole pregnancy). There was no association between maternal smoking during pregnancy and Tourette syndrome without comorbid ADHD (OR 0.5, 95 % CI 0.2-1.3, p = 0.166, OR 0.9, 95 % CI 0.7-1.3, p = 0.567). Further research is needed to elucidate the mechanisms behind the association between prenatal maternal smoking and Tourette syndrome with comorbid ADHD.

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“…To address genetic confounds, genetically-sensitive designs are needed to estimate the relative contributions of genetic factors and smoking during pregnancy. The results from D'Onofrio et al [78], Lindblad and Hjern [80], BosVeneman et al [81] suggest that the relationship between prenatal tobacco smoke exposure and ADHD may be influenced and/or confounded by familial factors, such as family history of mental disorders. As the example, the analysis based on large Swedish population-based cohort indicated dose-dependent relationship between foetal exposure to tobacco constituents assessed prospectively at prenatal visit and the risk of ADHD medications use in children at 6-19 years of age (OR = 1.9; 95% CI: 1.8-2.0 for the children of mothers who smoked ≥ 10 cigarettes per day during pregnancy in the entire study population) [80].…”

Section: Alcohol and Adhd Or Adhd Symptomsmentioning

confidence: 94%

Exposure to environmental and lifestyle factors and attention-deficit / hyperactivity disorder in children — A review of epidemiological studies

Polańska¹,

Jurewicz²,

Hanke³

2012

International Journal of Occupational Medicine and Environmental Health

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Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders in children. Although the mechanisms that lead to the development of ADHD remain unclear, genetic and environmental factors have been implicated. These include heavy metals and chemical exposures, nutritional and lifestyle/psychosocial factors. The aim of this review was to investigate the association between ADHD or ADHD-related symptoms and widespread environmental factors such as phthalates, bisphenol A (BPA), tobacco smoke, polycyclic aromatic hydrocarbons (PAHs), polyfluoroalkyl chemicals (PFCs) and alcohol. Medline, PubMed and Ebsco search was performed to identify the studies which analyze the association of prenatal and postnatal child exposure to environmental toxicants and lifestyle factors and ADHD or ADHD-related symptoms. The review is restricted to human studies published since 2000 in English in peer reviewed journals. Despite much research has been done on the association between environmental risk factors and ADHD or ADHD symptoms, results are not consistent. Most studies in this field, focused on exposure to tobacco smoke, found an association between that exposure and ADHD and ADHD symptoms. On the other hand, the impact of phthalates, BPA, PFCs, PAHs and alcohol is less frequently investigated and does not allow a firm conclusion regarding the association with the outcomes of interest.

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Role of Perinatal Adversities on Tic Severity and Symptoms of Attention Deficit/Hyperactivity Disorder in Children and Adolescents With a Tic Disorder

Cited by 26 publications

References 30 publications

Prenatal risk factors for Tourette Syndrome: a systematic review

Prenatal risk factors for Tourette Syndrome: a systematic review

Prenatal Maternal Smoking and Tourette Syndrome: A Nationwide Register Study

Exposure to environmental and lifestyle factors and attention-deficit / hyperactivity disorder in children — A review of epidemiological studies

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