Role of Peripheral Adenosine A1 Receptors in the Regulation of Sleep Apneas in Rats

Carley, David W.; Radulovački, Miodrag

doi:10.1006/exnr.1999.7167

Cited by 11 publications

(6 citation statements)

References 39 publications

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“…Intrinsic cholinergic drive is in part mediated by the pedunculo-pontine tegmental area, an area which is known to cause breathing instabilities and an increased generation of postsigh apneas (476). Thus, cholinergic modulation is not only relevant in the context of SIDS, but also sleep apnea (59, 253, 557). Carbachol injections into the peduncolo-pontine tegmental area significantly increase the apnea index in intact rats (59).…”

Section: G-protein Coupled Receptors and The Modulation Of Cellular Pmentioning

confidence: 99%

“…Thus, cholinergic modulation is not only relevant in the context of SIDS, but also sleep apnea (59, 253, 557). Carbachol injections into the peduncolo-pontine tegmental area significantly increase the apnea index in intact rats (59). Moreover, glutamate injection into this region causes erratic breathing and apneas (474, 475).…”

Section: G-protein Coupled Receptors and The Modulation Of Cellular Pmentioning

confidence: 99%

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The Cellular Building Blocks of Breathing

Ramirez

Doi

Garcia

et al. 2012

Comprehensive Physiology

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Respiratory brainstem neurons fulfill critical roles in controlling breathing: they generate the activity patterns for breathing and contribute to various sensory responses including changes in O2 and CO2. These complex sensorimotor tasks depend on the dynamic interplay between numerous cellular building blocks that consist of voltage-, calcium-, and ATP-dependent ionic conductances, various ionotropic and metabotropic synaptic mechanisms, as well as neuromodulators acting on G-protein coupled receptors and second messenger systems. As described in this review, the sensorimotor responses of the respiratory network emerge through the state-dependent integration of all these building blocks. There is no known respiratory function that involves only a small number of intrinsic, synaptic, or modulatory properties. Because of the complex integration of numerous intrinsic, synaptic, and modulatory mechanisms, the respiratory network is capable of continuously adapting to changes in the external and internal environment, which makes breathing one of the most integrated behaviors. Not surprisingly, inspiration is critical not only in the control of ventilation, but also in the context of “inspiring behaviors” such as arousal of the mind and even creativity. Far-reaching implications apply also to the underlying network mechanisms, as lessons learned from the respiratory network apply to network functions in general.

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Section: G-protein Coupled Receptors and The Modulation Of Cellular Pmentioning

confidence: 99%

Section: G-protein Coupled Receptors and The Modulation Of Cellular Pmentioning

confidence: 99%

The Cellular Building Blocks of Breathing

Ramirez

Doi

Garcia

et al. 2012

Comprehensive Physiology

View full text Add to dashboard Cite

show abstract

“…Caffeine, a nonspecific adenosine receptor antagonist, works to inhibit sleep by blocking the action of adenosine within the brain, which facilitates wakefulness. Finally, an A 1 R agonist (N (6)-p-sulfophenyladenosine) suppresses apnea during all sleep stages in rats, and this effect occurs via the peripheral nervous system [120]. In summary, adenosine during sleep apnea is released in response to hypoxia and may promote sleep but inhibits apnea episodes through A 1 R activation.…”

Section: Obstructive Sleep Apnea Syndromementioning

confidence: 97%

Adenosine and the Cardiovascular System: The Good and the Bad

Guieu

Deharo

Maille

et al. 2020

JCM

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Adenosine is a nucleoside that impacts the cardiovascular system via the activation of its membrane receptors, named A1R, A2AR, A2BR and A3R. Adenosine is released during hypoxia, ischemia, beta-adrenergic stimulation or inflammation and impacts heart rhythm and produces strong vasodilation in the systemic, coronary or pulmonary vascular system. This review summarizes the main role of adenosine on the cardiovascular system in several diseases and conditions. Adenosine release participates directly in the pathophysiology of atrial fibrillation and neurohumoral syncope. Adenosine has a key role in the adaptive response in pulmonary hypertension and heart failure, with the most relevant effects being slowing of heart rhythm, coronary vasodilation and decreasing blood pressure. In other conditions, such as altitude or apnea-induced hypoxia, obstructive sleep apnea, or systemic hypertension, the adenosinergic system activation appears in a context of an adaptive response. Due to its short half-life, adenosine allows very rapid adaptation of the cardiovascular system. Finally, the effects of adenosine on the cardiovascular system are sometimes beneficial and other times harmful. Future research should aim to develop modulating agents of adenosine receptors to slow down or conversely amplify the adenosinergic response according to the occurrence of different pathologic conditions.

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“…Adenosine receptors that modulate respiration are located in the carotid bodies of several mammalian species including man (Monteiro and Ribeiro; 1987; Watt and Routledge, 1985). It is also established that adenosine receptors that mediate respiratory excitation are of the A 2 subtype while the A 1 receptor subtype mediates depression (Monteiro and Ribeiro 1987; Carley and Radulovacki, 1999). …”

Section: Mechanism(s) Of Actionsmentioning

confidence: 99%

“…Adenosine A 1 receptor activation can reduce centrally mediated respiratory disturbances that occur during sleep (Carley and Radulovacki, 1999; Monti et al, 1996). Bae and colleagues (2005) tested the hypothesis that adenosine A 1 receptors localized in the carotid bodies can be specifically activated to modulate recovered respiratory activity in C2 hemisected rats.…”

Section: Mechanism(s) Of Actionsmentioning

confidence: 99%

Recovery of respiratory activity after C2 hemisection (C2HS): Involvement of adenosinergic mechanisms

Nantwi

2009

Respiratory Physiology & Neurobiology

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Consequences of spinal cord injury (SCI) depend on the level and extent of injury. Cervical SCI often results in a compromised respiratory system. Primary treatment of SCI patients with respiratory insufficiency continues to be with mechanical ventilatory support. In an animal model of SCI, an upper cervical spinal cord hemisection paralyzes the hemidiaphragm ipsilateral to the side of injury. However, a latent respiratory motor pathway can be activated to restore respiratory function after injury. In this review, restoration of respiratory activity following systemic administration of theophylline, a respiratory stimulant will be discussed. Pharmacologically, theophylline is a non specific adenosine receptor antagonist, a phosphodiesterase inhibitor and a bronchodilator. It has been used in the treatment of asthma and other respiratory-related diseases such as chronic obstructive pulmonary disease (COPD) and in treatment of apnea in premature infants.However, the clinical use of theophylline to improve respiration in SCI patients with respiratory deficits is a more recent approach. This review will focus on the use theophylline to restore respiratory activity in an animal model of SCI. In this model, a C2 hemisection (C2HS) interrupts the major descending respiratory pathways and paralyzes the ipsilateral hemidiaphragm. The review also highlights involvement of central and peripheral adenosine receptors in functional restitution. Biochemical binding assays that highlight changes in adenosine receptors after chronic theophylline administration are discussed as they pertain to understanding adenosine receptor-mediation in functional recovery. Finally, the clinical application of theophylline in SCI patients with respiratory deficits in particular is discussed.

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Role of Peripheral Adenosine A1 Receptors in the Regulation of Sleep Apneas in Rats

Cited by 11 publications

References 39 publications

The Cellular Building Blocks of Breathing

The Cellular Building Blocks of Breathing

Adenosine and the Cardiovascular System: The Good and the Bad

Recovery of respiratory activity after C2 hemisection (C2HS): Involvement of adenosinergic mechanisms

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