Role of peripheral GABAB receptors in the regulation of pepsinogen secretion in anaesthetized rats

Blandizzi, Corrado; Colucci, Rocchina; Carignani, D; Natale, Gianfranco; Lazzeri, Gloria; Crema, Francesca; Tacca, M. Del

doi:10.1016/0014-2999(95)00538-2

Cited by 14 publications

(12 citation statements)

References 32 publications

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“…Both GABA and GABA receptors have been identified within the gastrointestinal tract, including the gastric mucosa ( Erdo et al ., 1990 ; Gilon et al ., 1990 ; 1991 ; Harty et al ., 1991 ; Krantis et al ., 1994 ; Nakajima et al ., 1996 ; Castelli et al ., 1999 ). Functional data showed that GABA or preferential GABA A and GABA B agonists, administered peripherally, affect gastric acid secretion in rats, dogs and humans ( Goto & Debas, 1983 ; Pugh et al ., 1985 ; Thirlby et al ., 1988 ; Blandizzi et al ., 1991a ; 1991b ; 1992 ; 1995 ; Lin, 1995 ). In the present study, the peripheral administration of preferential GABA B agonists, R ‐baclofen and SKF‐97541 resulted in a dose‐related stimulation of acid secretion in mice, while the stimulation of GABA A or GABA C receptors was devoid of any effect.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies indicate that GABA modulates gastric acid secretion in several species, including humans. Both inhibitory and stimulatory effects of the GABAergic system on gastric acid secretion have been reported in rats, dogs and humans ( Goto & Debas, 1983 ; Pugh et al ., 1985 ; Thirlby et al ., 1988 ; Blandizzi et al ., 1991a ; 1991b ; 1992 ; 1995 ; Lin, 1995 ). Several studies suggest that the stimulatory effects of GABA on acid secretion are vagally mediated, associated to a direct effect on central GABA receptors ( Yamasaki & Goto, 1990a ; 1990b ).…”

Section: Introductionmentioning

confidence: 99%

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Peripheral GABA_B agonists stimulate gastric acid secretion in mice

Piqueras

Martínez

2004

British J Pharmacology

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1 We characterized the effects of intravenous GABA and preferential GABA A (muscimol), GABA B (R-baclofen and SKF-97541) and GABA C agonists (imidazole-4-acetic acid) on gastric acid secretion in urethane-anesthetized mice implanted with a gastric cannula, and determined the role of vagal cholinergic mechanisms, and gastrin and somatostatin by using peptide immunoneutralization, the SSTR2 antgonist, PRL-2903, and SSTR2 knockout mice. , i.v.) increased basal gastric acid secretion by 48%. Neither GABA nor muscimol nor imidazole-4-acetic acid modified basal gastric acid secretion in SSTR2 knockout mice. 6 These results indicate that, in mice, stimulation of GABA B receptors increases gastric acid secretion through vagal-and gastrin-dependent mechanisms. Somatostatin implication might be secondary to the release of gastrin and the increase in gastric luminal acidity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Peripheral GABA_B agonists stimulate gastric acid secretion in mice

Piqueras

Martínez

2004

British J Pharmacology

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“…Zymogen cells guided PGC expression in the absence of XBP1 and represented abnormal aggregation of original mucous neck cells [78]. Blandizzi et al reported that peripheral GABA B (gamma-aminobutyric acid type B receptor unit) receptors mediated an excitatory effect on gastric PG secretion, which depends entirely on acid output [79]. TGFα is best known as a highly potent mitogen, and has been associated with malignant transformation.…”

Section: The Regulation Of Pgc Expressionmentioning

confidence: 99%

Pepsinogen C expression, regulation and its relationship with cancer

Shen¹,

Jiang

Yuan

2017

Cancer Cell Int

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Pepsinogen C (PGC) belongs to the aspartic protease family and is secreted by gastric chief cells. PGC could be activated to pepsin C and digests polypeptides and amino acids, but as a zymogen PGC’s functions is unclear. In normal physiological conditions, PGC is initially detected in the late embryonic stage and is mainly expressed in gastric mucosa. The in situ expression of PGC in gastric mucosa is decreased considerably in the process of superficial gastritis → atrophic gastritis → gastric cancer (GC), proving that PGC is a comparatively ideal negative marker of GC. Serum PGC, and PGA levels and the PGA/PGC ratio have satisfactory sensitivity, specificity and price–quality ratio for predicting high GC risk. Ectopic PGC expression is significantly increased in prostate cancer, breast cancer, ovary cancer and endometrial cancer. In those sex-related cancers high level PGC expression indicates better prognosis and longer survival. The regulation of PGC expression involves genetic and epigenetic alteration of the encoding PGC gene, hormones modulation and interactions between PGC with other transcription factors and protein kinases. More and more research evidence hinted that PGC has strong correlation with cancer. In the systematic review, we respectively elaborate the structure, potential physiological functions, expression characteristics and regulation of PGC, and especially focus on the relationship between PGC expression and cancer to highlight the role of PGC in the tumorigenesis and its application value in clinical practice.

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“…The supernatant was then analysed for determination of pH according to the method of Hara et al (16), free and total acid concentrations were estimated by using the method of Pratha et al (17) and pepsin concentrations were determined by a modifi ed spectrophotometric method (18).…”

Section: Analysis Of the Gastric Juicementioning

confidence: 99%

Possible contribution of nitric oxide and prostaglandin in the protective effect of angiotensin (1-7) against stress induced gastric ulceration in adult male albino rats

A.¹,

Aziz²,

Muralinath.E³

et al. 2017

BLL

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To assess the gastro-protective potential of the angiotensin (Ang-) (1-7) on the gastric secretion and ulceration induced by cold restraint stress (CRS) in adult male rats and the possible contribution of nitric oxide and prostaglandin E 2 . Rats were pylorically ligated and divided randomly into the following groups (8 rats each): control, cold-restraint stressed (CRS), stressed Ang-(1-7) treated, stressed L-NNA-Ang-(1-7) treated, stressed Indo-Ang-(1-7) treated groups. Our results revealed that Ang-(1-7) pre-treatment proved to be protective against development of ulcerative lesions in CRS model as evidenced by histological examination and the reduction of the ulcer index and this could be mediated through reduction of free and total acidity and pepsin concentration of gastric secretion with signifi cantly decreased lipid peroxidation and increased the gastric protective nitric oxide and prostaglandin E 2 levels. Furthermore, Ang-(1-7) pre-treatment has anti-apoptotic effect, evident by its down-regulation of the CRS induced over-expression of the gastric caspase 3. In addition, the gastro-protective effects of Ang-(1-7) were signifi cantly attenuated by co-administration with L-NNA or indomethacin. In conclusion, Ang-(1-7) can be considered a potential therapeutic agent to protect against the major clinical challenge of gastric injury resulting from stress. Nitric oxide and prostaglandin E 2 seem to contribute to the Ang-(1-7)'s gastro-protective effect (Tab. 2, Fig. 5, Ref. 35). Text in PDF www.elis.sk.

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Role of peripheral GABAB receptors in the regulation of pepsinogen secretion in anaesthetized rats

Cited by 14 publications

References 32 publications

Peripheral GABA_B agonists stimulate gastric acid secretion in mice

Peripheral GABA_B agonists stimulate gastric acid secretion in mice

Pepsinogen C expression, regulation and its relationship with cancer

Possible contribution of nitric oxide and prostaglandin in the protective effect of angiotensin (1-7) against stress induced gastric ulceration in adult male albino rats

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Role of peripheral GABAB receptors in the regulation of pepsinogen secretion in anaesthetized rats

Cited by 14 publications

References 32 publications

Peripheral GABAB agonists stimulate gastric acid secretion in mice

Peripheral GABAB agonists stimulate gastric acid secretion in mice

Pepsinogen C expression, regulation and its relationship with cancer

Possible contribution of nitric oxide and prostaglandin in the protective effect of angiotensin (1-7) against stress induced gastric ulceration in adult male albino rats

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Product

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Peripheral GABA_B agonists stimulate gastric acid secretion in mice

Peripheral GABA_B agonists stimulate gastric acid secretion in mice