Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats

McRoberts, James A.; Coutinho, Santosh V.; Marvizón, Juan Carlos G.; Grady, Eileen F.; Tognetto, Michele; Sengupta, Jyoti N.; Ennes, Helena S.; Chaban, Victor V.; Amadesi, Silvia; Créminon, Christophe; Lanthorn, T H; Geppetti, Pierangelo; Bunnett, Nigel W.; Mayer, Emeran A.

doi:10.1053/gast.2001.24848

Cited by 195 publications

(161 citation statements)

References 57 publications

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“…N-methyl-D-aspartate (NMDA) receptor activation is considered one of the mechanisms of postoperative pain and hypersensitivity through both peripheral and central effects (4) .…”

Section: Introductionmentioning

confidence: 99%

Effect of Intraperitoneal Ketamine as Postoperative Analgesia in Laparoscopic Cholecystectomy

Shawky

Essa

Emam

2018

The Egyptian Journal of Hospital Medicine

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Background: Laparoscopic surgery is gaining popularity so different modalities of pain management should be used as patients experience postoperative pain of different sources especially from the abdomen, back and shoulder region which is severe especially in first postoperative hours. Objective: We aimed to evaluate effect of intraperitoneal instillation of ketamine and normal saline on postoperative pain and analgesic requirements after laparoscopic cholecystectomy. Patients and Methods: Forty patients undergoing laparoscopic cholecystectomy were randomly allocated and divided into two groups, The ketamine intraperitoneal (KIP) group (n=20 patients), in which 0.5 mg/kg ketamine diluted in 30 ml normal saline was instilled intraperitoneally,The saline intraperitoneal (SIP) group (n=20 patients), in which 30 ml of normal saline was instilled intraperitoneally. Patients receive these drugs as follow, 16 ml in gall bladder fossa while other 14 ml under copula of diaphragm on both sides while patients were placed in 15-20-degree trendelenburg position. This was done before patients recovered from anesthesia, then patients extubated and transferred to ward. Patients were evaluated according to VAS, time to first analgesic and total analgesic requirements during 24 hours post-operative. Results: Our results showed that usage of ketamine decreases postoperative pain and analgesic consumption in the first 24 hours after surgery along with longer pain free period compared to patients who were given bupivacaine after laparoscopic cholecystectomy. In our study ketamine 0.5mg/kg was safely used as we did not observe any sign of toxicity. Conclusion: Intraperitoneal instillation of local anesthetic is an easy, cheap and safe method which provides good analgesia in the immediate postoperative period after laparoscopic surgery. Ketamine is highly effective in postoperative pain control in laparoscopic cholecystectomy without any hazards on patients.

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“…N-methyl-D-aspartate (NMDA) receptor activation is considered one of the mechanisms of postoperative pain and hypersensitivity through both peripheral and central effects (4) .…”

Section: Introductionmentioning

confidence: 99%

Effect of Intraperitoneal Ketamine as Postoperative Analgesia in Laparoscopic Cholecystectomy

Shawky

Essa

Emam

2018

The Egyptian Journal of Hospital Medicine

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“…The NMDA involvement was further substantiated by its blockade in modulating the visceral nociception. [23,24] In addition, the peripheral terminals of primary afferent nerves innervating somatic tissues also express NMDA receptors. [25][26][27] Peripheral injection of NMDA receptor antagonist attenuates pain associated with neuropathic or inflammatory origin.…”

Section: Discussionmentioning

confidence: 99%

N-methyl-D-aspartate receptors mediate Mesobuthus tamulus venominduced vasosensory reflex responses in anesthetized rats

Singh¹,

Deshpande²

2017

Natl J Physiol Pharm Pharmacol

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Background:The autonomic changes and cardiorespiratory changes seen in vascular disorders are suggested to be mediated reflexly by the activation of perivascular nociceptors. The role of prostaglandins, vanilloid receptor 1, 5-hydroxytryptamine type 3, and kinin receptors is well established. Aims and Objectives: This study was conducted to understand the role of N-methyl-D-aspartate (NMDA) receptor in modulating vasosensory reflex responses evoked by Mesobuthus tumulus venom. Materials and Methods: Healthy male albino rats were anesthetized with an intra-peritoneal injection of urethane (1.5 g/kg). Tracheostomy was performed to keep the airway patent. Femoral artery was cannulated proximally as well as distally to record the blood pressure (BP) and to inject the chemicals, respectively. The effect of venom on BP, heart rate (HR), respiratory rate, and minute ventilation was recorded for 60 min at every 5 min and presented as mean ± standard error of mean. Results: Intra-arterial injection of venom produced immediate hyperventilatory response (increase of 41.6%), followed by hypoventilatory response (decrease of 40.1%), and finally sustained hyperventilatory response (increase of 53%) which was observed up to 60 min. The hypertensive response started at 40 s, peaking at 5 min (increase of 48%), and remained above the initial level subsequently. The bradycardiac response began around 5 min, peaking at 25 min (decrease of 50% in HR), and remained at that level up to 60 min. In 2-amino 5-phosphonovaleric acid (NMDA receptor antagonist) pre-treated group, the venom-induced cardiovascular responses (mean arterial pressure and HR) were markedly attenuated in comparisons to the venom only group but not the respiratory responses. Conclusions: The data provide evidence for the involvement of NMDA receptors in producing the venom-induced vasosensory reflex responses modulating the cardiovascular parameters in anesthetized rats.

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“…58 NMDA receptors are found on enteric extrinsic afferents from colon and bladder; these afferents release calcitonin gene-related peptide and substance P once the receptor is activated. 59 NMDA receptors within the rostral ventromedial medulla are important in modulating pain. 60 Miranda et al 61 reported that spinal NMDA receptors play an important role in the development of hyperalgesia following painful events early in life.…”

Section: 55mentioning

confidence: 99%

Role of Principal Ionotropic and Metabotropic Receptors in Visceral Pain

Kannampalli

Sengupta

2015

J Neurogastroenterol Motil

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Visceral pain is the most common form of pain caused by varied diseases and a major reason for patients to seek medical consultation. It also leads to a significant economic burden due to workdays lost and reduced productivity. Further, long-term use of non-specific medications is also associated with side effects affecting the quality of life. Despite years of extensive research and the availability of several therapeutic options, management of patients with chronic visceral pain is often inadequate, resulting in frustration for both patients and physicians. This is, most likely, because the mechanisms associated with chronic visceral pain are different from those of acute pain. Accumulating evidence from years of research implicates several receptors and ion channels in the induction and maintenance of central and peripheral sensitization during chronic pain states. Understanding the specific role of these receptors will facilitate to capitalize on their unique properties to augment the therapeutic efficacy while at the same time minimizing unwanted side effects. The aim of this review is to provide a concise review of the recent literature that reports on the role of principal ionotropic receptors and metabotropic receptors in the modulation visceral pain. We also include an overview of the possibility of these receptors as potential new targets for the treatment of chronic visceral pain conditions. (J Neurogastroenterol Motil 2015;21:147-158)

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Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats

Cited by 195 publications

References 57 publications

Effect of Intraperitoneal Ketamine as Postoperative Analgesia in Laparoscopic Cholecystectomy

Effect of Intraperitoneal Ketamine as Postoperative Analgesia in Laparoscopic Cholecystectomy

N-methyl-D-aspartate receptors mediate Mesobuthus tamulus venominduced vasosensory reflex responses in anesthetized rats

Role of Principal Ionotropic and Metabotropic Receptors in Visceral Pain

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