Role of PfMYST in DNA replication in Plasmodium falciparum

Shekhar, Shashank; Bhowmick, Krishanu; Dhar, Suman Kumar

doi:10.1016/j.exppara.2022.108396

Cited by 5 publications

(2 citation statements)

References 41 publications

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“…genomes; some are functionally characterized, others are still putative. Of all the histone acetyltransferases, PfGCN5 and PfMYST are the best characterized and are supposed to be essential for intraerythrocytic parasite forms [ 119 , 120 ]. The most extensively studied P.f.…”

Section: Protein Ptms In Plasmodium Parasite Growt...mentioning

confidence: 99%

Post-Translational Modifications of Proteins of Malaria Parasites during the Life Cycle

Schwarzer,

Skorokhod

2024

IJMS

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Post-translational modifications (PTMs) are essential for regulating protein functions, influencing various fundamental processes in eukaryotes. These include, but are not limited to, cell signaling, protein trafficking, the epigenetic control of gene expression, and control of the cell cycle, as well as cell proliferation, differentiation, and interactions between cells. In this review, we discuss protein PTMs that play a key role in the malaria parasite biology and its pathogenesis. Phosphorylation, acetylation, methylation, lipidation and lipoxidation, glycosylation, ubiquitination and sumoylation, nitrosylation and glutathionylation, all of which occur in malarial parasites, are reviewed. We provide information regarding the biological significance of these modifications along all phases of the complex life cycle of Plasmodium spp. Importantly, not only the parasite, but also the host and vector protein PTMs are often crucial for parasite growth and development. In addition to metabolic regulations, protein PTMs can result in epitopes that are able to elicit both innate and adaptive immune responses of the host or vector. We discuss some existing and prospective results from antimalarial drug discovery trials that target various PTM-related processes in the parasite or host.

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Section: Protein Ptms In Plasmodium Parasite Growt...mentioning

confidence: 99%

Post-Translational Modifications of Proteins of Malaria Parasites during the Life Cycle

Schwarzer,

Skorokhod

2024

IJMS

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“…The disordered N-terminal extension of MTIP is crucial for its interaction with GAP45, a component of the glideosome complex (Douse et al, 2012;Yusuf et al, 2015;Robert-Paganin et al, 2019). The conserved key acetyltransferase PfMYST, expressed in two isoforms in the parasite, consists of chromodomain, MYST acetyltransferase domain and zinc finger domain (Shekhar et al, 2022). Interestingly, N-terminal extensions are present in PfMYST, upstream of the chromodomain.…”

Section: N-terminal Extension Idiosyncrasy Through the Evolutionary P...mentioning

confidence: 99%

Targeting proteases and proteolytic processing of unusual N-terminal extensions of Plasmodium proteins: parasite peculiarity

Tehlan

Saha

Dhar

2023

Front. Drug Discov.

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More than sesquicentennial years of malarial research, however the unique malarial parasite, Plasmodium still bewilders us with its atypical characteristic features. Elimination strategies, deeper knowledge of the parasite biology and pathways can help combat this global health concern that affects ∼250 million people annually. In this review, we unveil an unusual phenomenon observed in the parasite proteome, N-terminal extensions in proteins and highlight that the proteases that may be involved in their processing events, are potential candidates to target this pathogen. Plasmodium encodes larger proteins as compared to its eukaryotic counterparts with homology regions present in the C-terminus of the protein. In contrast, the function of unusual extensions in the N-terminus remains mostly elusive. This novelty observed in Plasmodium proteins is collated here with a focus on replication proteins. The plausible functions and prevalence of these extensions, despite the reduction in genome size, through the parasite evolution are also mentioned. We hypothesize that these extensions, propagated via the energy consuming cellular processes in the otherwise host-dependent obligate parasite, are beneficial to the parasite in ways that are yet to be explored. Consequently, targeting the proteolytic processing of these proteins and the involved proteases would serve as a new drug development regimen to tackle the emerging resistance in parasites to existing antimalarials.

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Genome-wide binding sites of Plasmodium falciparum mini chromosome maintenance protein MCM6 show new insights into parasite DNA replication

Shekhar

Verma

Gupta

et al. 2023

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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Role of PfMYST in DNA replication in Plasmodium falciparum

Cited by 5 publications

References 41 publications

Post-Translational Modifications of Proteins of Malaria Parasites during the Life Cycle

Post-Translational Modifications of Proteins of Malaria Parasites during the Life Cycle

Targeting proteases and proteolytic processing of unusual N-terminal extensions of Plasmodium proteins: parasite peculiarity

Genome-wide binding sites of Plasmodium falciparum mini chromosome maintenance protein MCM6 show new insights into parasite DNA replication

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